Developmental Phonological Disorders

发育性语音障碍

• 批准号: 7931010
• 负责人: LAWRENCE D SHRIBERG
• 金额: $ 21.7万
• 依托单位: UNIVERSITY OF WISCONSIN-MADISON
• 依托单位国家: 美国
• 财政年份: 2009
• 资助国家: 美国
• 起止时间: 2009-09-24 至 2011-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7931010
• 关键词: 6 year old; Accounting; Achievement; Acoustics; Address; Adult; Affective; Age; Age-Years; Articulation Disorders; Auditory; Child; Childhood; Classification; Clinic; Clinical; Cognitive; Complex; Computer software; Conductive hearing loss; Data; Data Set; Databases; Development; Diagnostic; Diagnostic tests; Disabled Persons; Disease; Dissection; Distal; Dysarthria; Early Diagnosis; Educational process of instructing; Gender; Genetic; Genome Scan; Goals; Health Resources; Heredity; High Prevalence; Language; Linguistics; Longevity; Measures; Metric; Molecular Genetics; Motor; Multimedia; Nature; Neurodevelopmental Disorder; Otitis Media with Effusion; Participant; Pathologist; Phase; Phenotype; Prevalence; Prevention; Procedures; Process; Prospective Studies; Protocols documentation; Public Health; Qualifying; Reading Disabilities; Recurrence; Research; Research Personnel; Retrospective Studies; Risk; Risk Factors; Role; Sampling; Self Concept; Series; Severities; Site; Speech; Speech Delay; Speech Disorders; Speech Sound; Standardization; System; Testing; Training; Upper arm; Validation; Voice; Work; austin; base; biobehavior; clinically significant; comparative; comparative genomic hybridization; diagnostic accuracy; disease classification; endophenotype; genetic linkage analysis; handicapping condition; hearing impairment; knowledge base; literacy; middle ear disorder; motor control; nervous system disorder; peer; phonology; programs; prospective; psychosocial; software development; software systems; sound; speech processing; tool; trait; transmission process

DESCRIPTION (provided by applicant): This research program has developed an etiological classification system, the Speech Disorders Classification System (SDCS), that addresses both the distal and proximal causes of Speech Delay (SD). The long term objective is to contribute to the knowledge based needed for eventual prevention of SD. The two specific aims for the next proposed period are to extend the diagnostic accuracy of the SDCS and to complete a translational project that will make it freely available for research and practice. Ten databases will be used to complete six study series, including data from over 3,910 participants. Arm I: SDCS Validation. Three studies in Arm I will cross-validate and extend the diagnostic accuracy of the SDCS. A Reference Study will provide lifespan reference data for all SDCS measures, a Retrospective Study will provide the first retrospective test of the diagnostic accuracy of the SDCS, and a Prospective Study will provide the first prospective study of its diagnostic accuracy. Arm II: Descriptive-Explanatory Studies. Three studies in Arm II will provide diagnostic profiles and contribute to explanatory accounts for three etiological subtypes of SD. Speech Delay-Genetics studies will cross-validate phenotype markers and validate two new endophenotype markers in molecular genetics studies with collaborators at several sites. Speech-Delay-Otitis Media with Effusion (OME) studies will provide the first test of alternative severity levels of early fluctuant hearing loss associated with OME as risk factors for clinical and subclinical SD. Speech Delay-Apraxia of Speech (AOS) studies will provide the first comparative speech-prosody-voice data using the same perceptual- and acoustic-based measures for adult acquired AOS, AOS as a sequela of neurological disorder, AOS as a sign in complex neurodevelopmental disorders, and idiopathic childhood AOS. Arm III: Translational Project. A three-phase translational project will complete the SDCS software and develop multimedia SDCS training materials, beta test the software and training materials with samples of speech-language pathologists and children with SD of unknown origin, and make the SDCS and training materials freely available to qualified speech-language researchers and clinicians. The studies in this research program directly address the proximal and distal causes of SD of currently unknown origin. SD is risk factor for children's literacy achievement, positive self concept, peer acceptance, and limitations in vocational choices The high prevalence of SD at 6 years of age (3.8%: Shriberg, Tomblin, & McSweeny, 1999) places it among the most frequently occurring childhood disorders warranting public health resources for research in prevention, assessment, and treatment.7. PROJECT NARRATIVE Speech delays of currently unknown origin are a highly prevalent public health concern (3.8% at six years of age) that place children at risk for reading disability, psychosocial handicap, and vocational limitations. This research seeks to identify the causes of children's speech delays, with emphasis on the roles of heredity, early recurrent middle ear disease, and speech motor control. A translational project will provide speech-language pathologists with an assessment tool to make early and accurate diagnostic decisions, with implications for individualized treatment based on the type of speech delay.

描述（由申请人提供）：该研究计划开发了一个病因分类系统，即语音障碍分类系统（SDC），该系统既解决语音延迟（SD）的远端和近端原因。长期目标是为最终预防SD所需的知识做出贡献。下一个建议时期的两个具体目标是扩展SDC的诊断准确性，并完成一个可以自由使用研究和实践的转化项目。十个数据库将用于完成六个研究系列，包括来自3,910多名参与者的数据。 ARM I：SDCS验证。三项手臂研究将跨估算并延长SDC的诊断准确性。一项参考研究将为所有SDCS措施提供寿命参考数据，回顾性研究将对SDC的诊断准确性进行首次回顾性检验，前瞻性研究将为其诊断准确性提供首次前瞻性研究。 ARM II：描述性解释性研究。 ARM II研究的三项研究将提供诊断概况，并为SD的三种病因学亚型提供解释性记录。语音延迟生殖学研究将在与多个地点的合作者中的分子遗传学研究中跨越验证表型标记并验证两个新的内型标记。语音播放媒体与积液（OME）的研究将提供与与OME相关的早期波动性听力损失的替代严重程度，作为临床和亚临床SD的危险因素。语音延迟 - 语音（AOS）研究将使用相同的基于感知的和声学的措施为成人获得的AOS，AOS作为神经疾病的续集，为复杂的神经发育障碍和特发性儿童小时候AOS提供第一个比较语音 - 言论化的声音数据。 ARM III：翻译项目。一个三阶段的翻译项目将完成SDCS软件，并开发多媒体SDCS培训材料，Beta测试软件和培训材料，其中包括语音语言病理学家和具有未知来源的SD的样本，并使SDCS和培训材料可免费获得合格的语音语言研究人员和临床医生。该研究计划中的研究直​​接解决了目前未知来源的SD的近端和远端原因。 SD是儿童识字成就，积极的自我概念，同伴的接受以及职业选择的限制的危险因素，SD在6岁时的SD高患病率（3.​​8％：Shriberg，Tomblin，＆McSweeny，1999）将其置于最常见的儿童期疾病中，将其用于研究的公共卫生资源属于预测，评估和治疗。当前未知来源的项目叙述性延迟是非常普遍的公共卫生问题（六岁时3.8％），这使儿童处于阅读障碍，心理社会障碍和职业限制的风险中。这项研究旨在确定儿童言语延迟的原因，重点是遗传，早期经常性中耳病和语音运动控制的作用。一个翻译项目将为语音语言病理学家提供评估工具，以做出早期，准确的诊断决策，这对基于语音延迟类型的个性化治疗产生了影响。