AIDS and Aging Research Platform (AARP)

艾滋病和老龄化研究平台 (AARP)

• 批准号: 10396602
• 负责人: STEVEN N. AUSTAD
• 金额: $ 77.08万
• 依托单位: UNIVERSITY OF WASHINGTON
• 依托单位国家: 美国
• 财政年份: 2020
• 资助国家: 美国
• 起止时间: 2020-08-15 至 2025-04-30
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10396602
• 关键词: Acquired Immunodeficiency Syndrome; Address; Age; Age-associated memory impairment; Aging; American; Area; Behavioral Research; Biology of Aging; Brain; Capsicum; Cardiovascular Diseases; Caring; Cessation of life; Chronic Disease; Clinic; Clinical; Cognitive; Data; Development; Diabetes Mellitus; Elderly; Equipment and supply inventories; Future; Geriatrics; Gerontology; Geroscience; Goals; HIV; Hearing; Hospitalization; Impaired cognition; Individual; Infrastructure; Institutes; Intervention; Investigation; Kidney Diseases; Link; Liver diseases; Longevity; Malignant Neoplasms; Mentors; Metabolic syndrome; Modeling; Molecular; Monoclonal Antibody R24; Network Infrastructure; Neurocognition; Outcomes Research; Persons; Phenotype; Physical Function; Pilot Projects; Prevention; Research; Research Personnel; Resources; Science; Sensory; Shock; Site; Stroke; Syndrome; System; Testing; Time; Training; United States National Institutes of Health; Vision; Work; antiretroviral therapy; base; clinical care; clinical phenotype; clinical research site; cognitive testing; comorbidity; data integration; disability; exercise program; experience; falls; frailty; functional decline; functional disability; healthspan; human old age (65+); improved; insight; interdisciplinary collaboration; meetings; middle age; mortality; multiple chronic conditions; programs; response; small molecule; social; success; tool

ABSTRACT Effective antiretroviral therapy (ART) for people living with HIV (PLWH) has dramatically reduced mortality resulting in many surviving into middle and old age. Despite this success, PLWH experience high rates of comorbidities, multimorbidity (>1 major chronic illness), and functional decline at ages 10-15 years younger than uninfected controls. Geriatric syndromes, such as frailty and falls, are becoming more prevalent in PLWH. Thus, there is an urgent need to focus on the healthspan of PLWH rather than just mortality. Healthspan, in contrast to lifespan, is defined as the time someone is healthy not just alive. The Claude D. Pepper Older American Independence Centers (OAlCs) were established to help define aging phenotypes and advance research into the causes, prevention and treatment of functional decline with age. OAlCs have developed and validated functional assessments in aging, but lack depth and breadth of HIV expertise. In contrast, Centers for AIDS Research (CFARs) have unparalleled expertise in HIV-related basic, clinical and social/behavioral research, but lack robust resources and expertise in aging biology, geriatric clinical phenotypes and functional assessments. Our R24 project, “Developing Research At The Interface Of HIV And Aging” was in response to PA-12-064 "Network and Infrastructure Support for Development of Interdisciplinary Aging Research." Through this R24 we successfully linked CFARs and OAICs to support pilot projects in high-priority focus areas and mentor researchers at the interface of HIV and Aging. Our vision for this proposal is to build on this success deepening the ongoing linkage of CFARs and OAICs and expanding the network to include Nathan Shock Centers of Excellence in the Basic Biology of Aging (NSCs) and the McKnight Brain Institutes (MBIs). By bringing together OAICs expertise on functional decline in aging, with NSC expertise in aging biology and the mechanisms underlying function decline, with MBI expertise on age-related cognitive decline, and CFAR expertise on HIV, we create an integrated approach to advancing and accelerating investigation at the interface of HIV and aging via the following Aims: Aim 1. Provide specific training models and a brief inventory of tools to efficiently collect data to improve HIV clinical care and outcomes research. Aim 2. Using a geroscience approach, provide a platform for pilot studies to determine the links between molecular hallmarks of aging with functional decline, and the development of common comorbidities among aging PLWH. Aim 3. Develop infrastructure for evaluating interventional approaches and their application to HIV care. Aim 4. Provide educational support, implementation advice and mentoring for emerging investigators to establish/advance research programs in HIV and aging. These synergistic aims leverage and expand the infrastructure and close ties built in the R24 of HIV expertise from CFARs with the gerontology and functional assessment expertise within the OAlCs and expand them with inclusion of NSCs and MBIs to enhance and accelerate investigation at the interface of HIV and aging.

抽象的 对艾滋病毒感染者 (PLWH) 进行有效的抗逆转录病毒治疗 (ART) 显着降低了死亡率 尽管取得了这些成功，但艾滋病毒感染者和艾滋病患者的感染率仍然很高。 合并症、多重疾病（>1 种主要慢性病）和 10-15 岁时的功能衰退 与未感染的对照组相比，老年综合症（例如虚弱和跌倒）在艾滋病毒感染者中变得更加普遍。 因此，迫切需要关注感染者的健康寿命，而不仅仅是死亡率。 与寿命相反，寿命被定义为一个人健康的时间，而不仅仅是活着的时间。 美国独立中心 (OAlC) 的成立是为了帮助定义衰老表型并推进 随着年龄的增长，对 OAlC 功能衰退的原因、预防和治疗的研究已经展开。 衰老方面的功能评估得到了验证，但缺乏艾滋病毒专业知识的深度和广度。 艾滋病研究 (CFAR) 在艾滋病毒相关基础、临床和社会/行为方面拥有无与伦比的专业知识 研究，但缺乏衰老生物学、老年临床表型和功能方面的强大资源和专业知识 我们的 R24 项目“在艾滋病毒与衰老的相互作用方面开展研究”是为了回应 PA-12-064“跨学科老龄化研究发展的网络和基础设施支持。” 在 R24 中，我们成功地将 CFAR 和 OAIC 联系起来，以支持高优先重点领域的试点项目和 我们对这项提案的愿景是在这一成功的基础上再接再厉。 深化 CFAR 和 OAIC 之间的持续联系，并扩大网络以纳入 Nathan Shock 衰老基础生物学卓越中心 (NSC) 和麦克奈特脑研究所 (MBI)。 汇集 OAIC 在衰老功能衰退方面的专业知识、NSC 在衰老生物学方面的专业知识以及 功能衰退的机制，MBI 在年龄相关认知衰退方面的专业知识，以及 CFAR 凭借艾滋病毒方面的专业知识，我们创建了一种综合方法来推进和加速艾滋病毒调查 艾滋病毒与衰老的相互作用通过以下目标实现： 目标 1. 提供具体的培训模型和简要的工具清单，以有效收集数据以改善艾滋病毒 目标 2. 使用老年科学方法，为试点研究提供平台。 确定衰老的分子特征与功能衰退之间的联系，以及 目标 3. 开发评估介入治疗的基础设施。 目标 4. 提供教育支持、实施建议和指导。 指导新兴研究人员建立/推进艾滋病毒和老龄化研究项目。 这些协同目标利用并扩展了艾滋病毒专业知识 R24 中建立的基础设施和密切联系 来自 CFAR 与 OAlC 内的老年学和功能评估专业知识，并将其扩展为 将 NSC 和 MBI 纳入其中，以加强和加速艾滋病毒与老龄化交叉点的研究。