KU Bioinformatics Computing Facility Core Renovation and Improvement

KU生物信息学计算设施核心改造和改进

• 批准号: 7936024
• 负责人: STEVEN F. WARREN
• 金额: $ 465.79万
• 依托单位: UNIVERSITY OF KANSAS LAWRENCE
• 依托单位国家: 美国
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-04-29 至 2012-12-28
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7936024
• 关键词: Address; Bioinformatics; Biological; Biomedical Computing; Biomedical Research; Centers of Research Excellence; Chemicals; Chemistry; Communities; Core Facility; Data; Data Storage and Retrieval; Development; Floods; Floor; Funding; Future; Grant; High Performance Computing; Kansas; Laboratories; Libraries; Life; Mass Spectrum Analysis; Medical center; Methodology; Microscopy; Modeling; Molecular; National Center for Research Resources; National Institute of General Medical Sciences; Process; Research Personnel; Research Project Grants; Resources; Rest; Science; Services; System; Time; United States National Institutes of Health; Universities; X-Ray Crystallography; base; computing resources; density; design; experience; high throughput screening; improved; instrument; instrumentation; meetings; multidisciplinary; simulation; square foot

DESCRIPTION (provided by applicant): The University of Kansas Lawrence campus requests funding to renovate and expand 3646 gross square feet (gsf) in Nichols Hall designated as the Bioinformatics Computing Facility core (BCF). The renovated space will support computationally intensive multidisciplinary and integrative research projects in the biological and biomedical sciences across many departments of the University and at the KU Medical Center. The BCF supports four dozen NIH projects, two NCRR COBRE grants, a NIGMS Chemical Methodologies and Library Development (CMLD) project, a MLI Specialized Chemistry Center, and ten core service laboratories. These laboratories provide analytical instrumentation and technical services such as molecular interrogation, high throughput screening, microscopy, and biomolecular sequencing to the University's biological and biomedical sciences researchers. The proposed computational commons will be a sustainable, energy efficient data center for hosting existing and future assets dedicated to biological and biomedical computing. Computing is becoming an indispensible component in the biological and biomedical research. Biomedical related computation is driven by three factors: huge and growing amounts of data from instruments such as biomolecular sequencers, mass spectrometry, X-ray crystallography and high throughput screening systems; simulation aimed at understanding the fundamental processes of life at many scales through the development and integration of models of ever greater complexity; and a flood of new questions arising from the availability of data from instruments whose answers depend on modeling and computation. This precisely mirrors our experiences, we have seen a large increase in the number of biological and biomedical science projects that require high performance computing and large scale storage of data. These factors, along with a rapidly expanding computing and storage hardware base that has outgrown the existing facility makes meeting current and future demands of an active biomedical computing community difficult, if not impossible. The proposed renovation will provide the capacity needed to host the computing and storage resources capable of addressing these new challenges in biomedical research through an expanded computing commons. The project will renovate 3646 gsf, including 1232 gsf on the first floor of Nichols Hall as the primary machine room for the existing BCF and additional 2414 gsf as support space. This renovated space, along with additional power, cooling and network bandwidth, will support a high-density computing capacity twenty times greater than what is currently available to BCF users in a highly sustainable and energy efficient design. The proposed renovations will also improve network connectivity between this facility and the rest of the campus, increasing the accessibility of computational resources within and outside the university.

描述（由申请人提供）：堪萨斯大学劳伦斯大学校园要求资助在尼科尔斯厅（Nichols Hall）翻新和扩展3646总平方英尺（GSF），称为生物信息学计算机核心（BCF）。翻新的空间将支持该大学许多部门和KU医疗中心的生物学和生物医学科学的计算密集型多学科和综合研究项目。 BCF支持四打NIH项目，两个NCRR毛绒赠款，Nigms化学方法和图书馆开发项目（CMLD）项目，一个MLI专业化学中心和十个核心服务实验室。这些实验室为大学的生物学和生物医学研究人员提供了分析仪器和技术服务，例如分子询问，高通量筛查，显微镜和生物分子测序。拟议的计算共享将是一个可持续的，节能的数据中心，用于托管专门用于生物学和生物医学计算的现有和将来的资产。计算正在成为生物学和生物医学研究中不可或缺的组成部分。生物医学相关的计算由三个因素驱动：来自生物分子测序仪，质谱，X射线晶体学和高吞吐量筛选系统等工具的大量数据；模拟旨在通过发展和整合更复杂的模型，以了解许多尺度上生活的基本过程。以及由于答案取决于建模和计算的工具的可用性而引起的大量新问题。这恰恰反映了我们的经验，我们看到需要高性能计算和大规模数据存储的生物学和生物医学项目的数量大大增加。这些因素，加上迅速扩展的计算和存储硬件基础，使现有设施超过了现有设施，这使得满足了活跃的生物医学计算社区的当前和未来需求，即使不是不可能的话。拟议的翻新工程将提供所需的能力，以托管能够通过扩展的计算共同体解决生物医学研究中这些新挑战的计算和存储资源。该项目将翻新3646 GSF，其中包括尼科尔斯大厅一楼的1232 GSF，作为现有BCF的主要机器和其他2414 GSF作为支持空间。经过翻新的空间，以及额外的功率，冷却和网络带宽，将支持高密度计算能力的二十倍，比目前在高度可持续和节能设计的BCF用户中可用。拟议的翻新工程还将改善该设施与校园其他地区之间的网络连通性，从而增加大学内部和外部计算资源的可访问性。