MEIOTIC RECOMBINATION IN THE YEAST S CEREVISIAE

酿酒酵母中的减数分裂重组

• 批准号: 8169197
• 负责人: Scott Keeney
• 金额: $ 0.23万
• 依托单位: ROCKEFELLER UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-03-01 至 2011-02-28
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8169197
• 关键词: Cleaved cell; Computer Retrieval of Information on Scientific Projects Database; DNA; DNA Double Strand Break; Funding; Genetic Recombination; Grant; Institution; Meiotic Recombination; Outcome; Process; Regulation; Research; Research Personnel; Resources; SPO11 gene; Saccharomyces cerevisiae; Source; Spo11 protein; Topoisomerase; United States National Institutes of Health; Yeasts

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The following summary is taken from the Keeney Lab we page: "Meiotic recombination is initiated by DNA double-strand breaks (DSBs) generated by the topoisomerase-like Spo11 protein. We are studying the mechanism and regulation of Spo11-dependent DSB formation in the yeast S. cerevisiae, as well as examining the factors that dictate where Spo11 cleaves the DNA and that control the outcome of the recombination process."

该副本是利用众多研究子项目之一 由NIH/NCRR资助的中心赠款提供的资源。子弹和 调查员（PI）可能已经从其他NIH来源获得了主要资金， 因此可以在其他清晰的条目中代表。列出的机构是 对于中心，这不一定是调查员的机构。 以下摘要是从我们页面的Keeney Lab中获取的： “减数分裂重建是由拓扑酶样SPO11蛋白产生的DNA双链断裂（DSB）引发的。我们正在研究酵母菌中Spo11依赖性DSB形成的机制和调节，在酵母菌S. cerevisiae中的DSB形成，并检查了Spo11 Cleavis cleavistion spo Cleaves contsect contose contosce the DNA和recom controce of DNA和recomption forcome的依赖的方法。