MEIOTIC RECOMBINATION IN THE YEAST S CEREVISIAE

酿酒酵母中的减数分裂重组

• 批准号: 8169197
• 负责人: Scott Keeney
• 金额: $ 0.23万
• 依托单位: ROCKEFELLER UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-03-01 至 2011-02-28
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8169197
• 关键词: Cleaved cell; Computer Retrieval of Information on Scientific Projects Database; DNA; DNA Double Strand Break; Funding; Genetic Recombination; Grant; Institution; Meiotic Recombination; Outcome; Process; Regulation; Research; Research Personnel; Resources; SPO11 gene; Saccharomyces cerevisiae; Source; Spo11 protein; Topoisomerase; United States National Institutes of Health; Yeasts

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The following summary is taken from the Keeney Lab we page: "Meiotic recombination is initiated by DNA double-strand breaks (DSBs) generated by the topoisomerase-like Spo11 protein. We are studying the mechanism and regulation of Spo11-dependent DSB formation in the yeast S. cerevisiae, as well as examining the factors that dictate where Spo11 cleaves the DNA and that control the outcome of the recombination process."

该子项目是利用该技术的众多研究子项目之一 资源由 NIH/NCRR 资助的中心拨款提供。子项目及 研究者 (PI) 可能已从 NIH 的另一个来源获得主要资金， 因此可以在其他 CRISP 条目中表示。列出的机构是 对于中心来说，它不一定是研究者的机构。 以下摘要摘自 Keeney Lab 我们的页面： “减数分裂重组是由类拓扑异构酶 Spo11 蛋白产生的 DNA 双链断裂 (DSB) 启动的。我们正在研究酿酒酵母中 Spo11 依赖性 DSB 形成的机制和调节，并研究影响其形成的因素。决定了 Spo11 在何处切割 DNA 并控制重组过程的结果。”