MECHANISMS IN REGULATING DNA DAMAGE-INDUCED GENES IN A UMUC-DEFICIENT BACTERIUM

UMUC 缺陷细菌中 DNA 损伤诱导基因的调节机制

• 批准号: 8168293
• 负责人: Janelle M Hare
• 金额: $ 12.67万
• 依托单位: UNIVERSITY OF LOUISVILLE
• 依托单位国家: 美国
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-05-01 至 2011-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8168293
• 关键词: Bacteria; Breast; Cells; Cleaved cell; Colon; Computer Retrieval of Information on Scientific Projects Database; DNA; DNA Damage; DNA Repair; DNA-Directed DNA Polymerase; Funding; Genes; Goals; Grant; Health; Human; Institution; Link; Malignant neoplasm of ovary; Organism; Pathway interactions; Proteins; Research; Research Personnel; Resources; Role; SOS Response; Source; United States National Institutes of Health; human DNA damage; repaired

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The long term goal of this research is to understand the mechanisms by which cells respond to DNA damage. The link between DNA damage and human health is well-established: the inability to correctly repair damaged DNA can result in various forms of colon, breast, and ovarian cancers in humans. The existence of similar, extensive DNA damage sensing and repair mechanisms in organisms ranging from humans to bacteria demonstrates this central role of DNA integrity. In the typical bacterial SOS response pathway, after DNA damage, the UmuD protein self-cleaves, and then acts with its partner, UmuC, to function as a translesion synthesis DNA polymerase.

该副本是利用众多研究子项目之一 由NIH/NCRR资助的中心赠款提供的资源。子弹和 调查员（PI）可能已经从其他NIH来源获得了主要资金， 因此可以在其他清晰的条目中代表。列出的机构是 对于中心，这不一定是调查员的机构。 这项研究的长期目标是了解细胞对DNA损伤反应的机制。 DNA损害与人类健康之间的联系是良好的：无法正确修复受损的DNA可以导致人类​​中各种形式的结肠，乳腺癌和卵巢癌。从人类到细菌的生物中存在相似，广泛的DNA损伤感应和修复机制的存在证明了DNA完整性的核心作用。在典型的细菌SOS响应途径中，DNA损伤后，UMUD蛋白自裂解，然后与其伴侣UMUC一起起作用，以充当跨质量合成DNA聚合酶。