DNA BREAK REPAIR PROTEIN PHOSPHORYLATION

DNA 断裂修复蛋白磷酸化

• 批准号: 8361568
• 负责人: Scott Keeney
• 金额: $ 0.26万
• 依托单位: ROCKEFELLER UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2011
• 资助国家: 美国
• 起止时间: 2011-03-01 至 2012-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8361568
• 关键词: Coupled; DNA; DNA Repair Pathway; Funding; Grant; National Center for Research Resources; Phosphorylation; Phosphorylation Site; Post Translational Modification Analysis; Principal Investigator; Research; Research Infrastructure; Resources; Saccharomycetales; Source; United States National Institutes of Health; base; cost; macromolecule; repaired; yeast protein

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. Primary support for the subproject and the subproject's principal investigator may have been provided by other sources, including other NIH sources. The Total Cost listed for the subproject likely represents the estimated amount of Center infrastructure utilized by the subproject, not direct funding provided by the NCRR grant to the subproject or subproject staff. In budding yeast, the protein Rec104 is involved in the DNA repair pathway. Using immuno-isolation of endogenous rec104 coupled with MS-based analysis of post-translational modification we aim to determine what the sites of phosphorylation are on Rec104

该副本是利用资源的众多研究子项目之一 由NIH/NCRR资助的中心赠款提供。对该子弹的主要支持 而且，副投影的主要研究员可能是其他来源提供的 包括其他NIH来源。 列出的总费用可能 代表subproject使用的中心基础架构的估计量， NCRR赠款不直接向子弹或副本人员提供的直接资金。 在发芽的酵母中，蛋白质REC104参与了DNA修复途径。 使用内源性REC104的免疫隔离以及基于MS的翻译后修饰分析，我们旨在确定REC104的磷酸化位置