Air Pollution and Autism in Israel: A Population-Wide Study

以色列的空气污染和自闭症：一项全人口研究

• 批准号: 9349509
• 负责人: Marc G Weisskopf
• 金额: $ 16.86万
• 依托单位: HARVARD SCHOOL OF PUBLIC HEALTH
• 依托单位国家: 美国
• 财政年份: 2016
• 资助国家: 美国
• 起止时间: 2016-09-30 至 2019-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9349509
• 关键词: Address; Air Pollutants; Air Pollution; Autistic Disorder; Back; Biological Factors; Caliber; California; Characteristics; Child; Cohort Studies; Confounding Factors (Epidemiology); Data; Data Sources; Databases; Development; Dose; Dust; European; Event; Exposure to; Family; Family Characteristics; Fetus; Future; Genetic; Goals; Health; Hour; Incidence; Individual; Investigation; Israel; Link; Maternal Exposure; Modeling; Nitrogen Dioxide; Particulate Matter; Perinatal; Pollution; Population; Population Research; Pregnancy; Prevalence; Public Health; Regulation; Resolution; Rest; Risk; Risk Factors; Role; Siblings; Specificity; Sweden; Symptoms; Taiwan; Time; Tracer; Twin Multiple Birth; Variant; Vulnerable Populations; Work; autism spectrum disorder; base; boys; coarse particles; cohort; evidence base; girls; improved; male; maternal stress; modifiable risk; offspring; pollutant; prenatal exposure; response; sex; spatiotemporal; traffic-related air pollution

Project Summary/Abstract Several studies have explored associations of air pollution with autism spectrum disorders (ASD), with all but one suggesting that some aspect of air pollution increases the risk of ASD, but details of this association remain uncertain. While these studies have found associations with, in particular, traffic-related pollutants and particulate matter (PM), they have in general been relatively small and most have been limited to California. One study in Taiwan, one in Sweden (among twins), and one combining several European cohorts are the only non-U.S. studies, and they came to different conclusions. More exploration of these exposures are needed outside the U.S. context. Furthermore, understanding critical windows of exposure, and susceptible populations is critical. A study of ours and one other have suggested effects specific to the 3rd trimester. Prior work of ours has also suggested that associations with air pollutants may be specific to boys, but the numbers of ASD cases among girls were too small to adequately address this. Our goal is to examine the basic question of the association between maternal exposure to air pollutants and ASD, and details of any association, in a very large cohort in a very different setting: the population of Israel. Israel represents a unique setting for the study of air pollutants and ASD for several reasons: 1) Air pollution levels are higher and with a wider range than in the US; 2) Dust storms occur sporadically that create very well timed extreme exposure events to a very different form of PM; 3) we have well-validated, highly resolved—in both space and time—models of both PM and nitrogen dioxide (NO2, a marker of traffic-related air pollution) exposure; and 4) the database is very large with over 8,000 ASD cases across the entire Israeli population going back several years. With these data we will examine the association between maternal exposure to PM, NO2, and dust storms and risk of ASD in her child. We will have exposure estimates on a weekly time scale and can examine susceptible windows of exposure in the perinatal period, and whether any association is specific to boys or modified by other key factors, such as whether the family is simplex or multiplex, to an extent not previously done.

项目概要/摘要 几项研究探讨了空气污染与自闭症谱系障碍 (ASD) 之间的关联，但除 一项研究表明空气污染的某些方面会增加自闭症谱系障碍的风险，但这种关联的详细信息 虽然这些研究发现与交通相关的污染物和污染物之间存在关联，但仍不确定。 颗粒物 (PM) 总体来说相对较小，并且大多数仅限于加利福尼亚州。 台湾的一项研究、瑞典的一项研究（双胞胎）以及一项结合多个欧洲队列的研究是唯一的 非美国研究，他们得出了不同的结论，需要对这些暴露进行更多探索。 此外，了解美国以外的关键暴露窗口和脆弱性。 我们和其他人的一项研究表明了对妊娠第三个月的特定影响。 我们的工作还表明，与空气污染物的关联可能只针对男孩，但数量 女孩中自闭症谱系障碍病例的数量太少，无法充分解决这个问题。我们的目标是研究这个基本问题。 母亲接触空气污染物与自闭症谱系障碍之间的关联，以及任何关联的详细信息，在 非常不同的环境中的大量群体：以色列人口代表了一个独特的环境。 研究空气污染物和自闭症谱系障碍有以下几个原因：1）空气污染水平更高、范围更广 2) 沙尘暴时有发生，造成了非常及时的极端暴露事件 非常不同的 PM 形式；3）我们在空间和时间上都有经过充分验证的、高度解析的模型 PM 和二氧化氮（NO2，交通相关空气污染的标志）暴露；4）数据库非常丰富； 根据这些数据，以色列全国人口中已有 8,000 多例自闭症谱系障碍病例。 我们将研究母亲接触 PM、NO2 和沙尘暴与 ASD 风险之间的关系 我们将每周进行一次暴露估计，并可以检查她的孩子的脆弱性窗口。 围产期暴露，以及是否存在任何特定于男孩的关联或经过其他关键因素的修改 因素，例如家庭是单一家庭还是多重家庭，其程度是以前从未做过的。