The ACT annual symposium: a living, learning, national collaboratory to advance Alzheimer's disease and brain aging research

ACT 年度研讨会：一个活跃、学习、推进阿尔茨海默病和大脑衰老研究的国家合作机构

• 批准号: 9395822
• 负责人: Eric B Larson
• 金额: $ 4.95万
• 依托单位: KAISER FOUNDATION RESEARCH INSTITUTE
• 依托单位国家: 美国
• 财政年份: 2017
• 资助国家: 美国
• 起止时间: 2017-05-12 至 2018-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9395822
• 关键词: Adult; Affect; Aging; Alzheimer' s Disease; Alzheimer' s Disease patient registry; Biology; Biometry; British; Cessation of life; Clinical; Collaborations; Communities; Consultations; DNA; Data; Dementia; Discipline; Disease; Early Diagnosis; Ecology; Elderly; Epidemiology; Faculty; Feedback; Funding; Funding Agency; Future; Genetic; Goals; Grant; Health; Health Services; Image; Institution; Internal Medicine; International; Investments; Journals; Laboratories; Learning; Location; Medical; Medicine; Methods; Mind; Neurobiology; Neurology; New England; Paper; Parents; Pharmacoepidemiology; Prevention; Publishing; Radiologic Health; Recruitment Activity; Research; Research Infrastructure; Research Personnel; Resources; Scientist; Time; Traumatic Brain Injury; Travel; Universities; Washington; Work; aging brain; base; brain tissue; collaboratory; data sharing; disease diagnosis; experience; improved; innovation; molecular phenotype; neuropathology; parent grant; prospective; research study; resilience; symposium; trend

Project Summary/Abstract Alzheimer's disease (AD) diagnoses and deaths are on the rise – 5.4 million are currently living with the disease and 700,000 will die in 2016 alone. There is no sure-fire method for prevention, early detection, or cure. The Adult Changes in Thought (ACT) study has recruited over 5,000 adults over the age of 65 since 1994, and follows them every 2 years for new dementia and AD diagnoses. ACT data contribute to a living, learning co-laboratory, which serves the research community as a valuable scientific resource for AD and brain aging research. For the past four years, we have held an annual ACT Symposium to highlight new ACT resources, innovative research findings, and cross-disciplinary collaborations. We have done this with minimal support from the ACT parent U01. This conference grant will provide new support for our growing symposia for the next three years. The specific objectives of our conference grant are to: 1) promote appropriate scientific use and understanding of ACT data; 2) promote collaborations across scientific disciplines, institutions, and studies; and 3) provide opportunities for feedback on ongoing and planned work including analyses in progress and new grant ideas particularly for junior investigators. This new funding source will provide support for us to move our conference location to a larger, more technologically advanced facility. It will also provide travel stipends for investigators traveling from out of town so that we may extend our reach to new external investigators. We anticipate that future conferences (in late summer of 2017, 2018, and 2019 in Seattle, Washington) will cover hot topics in aging and dementia research such as resilience, imaging, dementia subtypes, molecular phenotypes, and traumatic brain injury – topic to which ACT is making significant contributions. Long term, expanding our ACT symposia will increase use of the ACT living laboratory, and advance AD and brain aging research.

项目摘要/摘要 阿尔茨海默氏病（AD）诊断和死亡正在增加 - 目前有540万 仅2016年，疾病和700,000就死亡。没有肯定的防止方法可以预防，早期检测或 治愈。自以来，成人思想变化（ACT）研究已招募了65岁以上的5,000多名成年人 1994年，每2年跟随他们进行新的痴呆症和广告诊断。 ACT数据有助于谋生， 学习共同解释，该研究社区是广告和大脑的宝贵科学资源 老化研究。在过去的四年中，我们举办了年度ACT研讨会，以突出新的法案 资源，创新研究结果和跨学科合作。我们以最少的方式做到了 ACT父母U01的支持。这项会议赠款将为我们不断增长的研讨会提供新的支持 接下来的三年。我们会议赠款的具体目标是：1）促进适当的科学 对ACT数据的使用和理解； 2）促进跨科学学科，机构和 研究； 3）提供了正在进行的反馈和计划中的工作的机会，包括正在进行的分析 和新的赠款思想，尤其是针对初级调查人员的想法。这个新的资金来源将为我们提供支持 将我们的会议地点转移到更大，技术上更高级的设施。它也将提供旅行 从城外旅行的调查人员的津贴，以便我们可以将覆盖范围扩展到新的外部 调查人员。我们预计未来会议（2017年夏末，2018年和2019年在西雅图， 华盛顿）将涵盖衰老和痴呆研究中的热门话题，例如弹性，成像，痴呆 亚型，分子表型和创伤性脑损伤 - 行动使大量重要的主题 贡献。长期，扩大我们的法案专题讨论会将增加对生活实验室的使用，并 提前广告和大脑衰老研究。