POLYMAVIRUS IN HUMAN RENAL ALLOGRAFT TISSUE

人肾同种异体移植组织中的多聚病毒

• 批准号: 8364282
• 负责人: PARMJEET S RANDHAWA
• 金额: $ 0.11万
• 依托单位: CARNEGIE-MELLON UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2011
• 资助国家: 美国
• 起止时间: 2011-09-15 至 2013-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8364282
• 关键词: Adult; Allografting; Biomedical Research; Disease Progression; Distress; Funding; Genomics; Grant; High Performance Computing; Human; Immunosuppressive Agents; Kidney; Kidney Diseases; Kidney Transplantation; National Center for Research Resources; Pharmaceutical Preparations; Play; Principal Investigator; Research; Research Infrastructure; Resources; Role; Source; Structure; Tissues; Transplant Recipients; United States National Institutes of Health; Viral; Virus; cost; kidney allograft

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. Primary support for the subproject and the subproject's principal investigator may have been provided by other sources, including other NIH sources. The Total Cost listed for the subproject likely represents the estimated amount of Center infrastructure utilized by the subproject, not direct funding provided by the NCRR grant to the subproject or subproject staff. Polymavirus is latent in the kidney of up to 50% of healthy adults. In kidney transplant patients maintained on immunosuppressive drugs, reactivation of virus can result in polymovirus allograft nephropathy (PVAN). PVAN is an inadequately studied and distressing condidtion that frequently leads to graft loss. The study being proposed explores the notion that changes in viral genomic structure might play an important role in the initiation and subsequent progression of this disease

该子项目是利用资源的众多研究子项目之一 由 NIH/NCRR 资助的中心拨款提供。子项目的主要支持 并且子项目的主要研究者可能是由其他来源提供的， 包括其他 NIH 来源。 子项目可能列出的总成本 代表子项目使用的中心基础设施的估计数量， NCRR 赠款不直接向子项目或子项目工作人员提供资金。 多瘤病毒潜伏在高达 50% 的健康成年人的肾脏中。在持续服用免疫抑制药物的肾移植患者中，病毒重新激活可导致多病毒同种异体移植肾病（PVAN）。 PVAN 是一种研究不足且令人痛苦的疾病，经常导致移植物丢失。拟议的研究探讨了病毒基因组结构的变化可能在这种疾病的发生和随后的进展中发挥重要作用的概念