POLYMAVIRUS IN HUMAN RENAL ALLOGRAFT TISSUE

人肾同种异体移植组织中的多聚病毒

• 批准号: 7723380
• 负责人: PARMJEET S RANDHAWA
• 金额: $ 0.05万
• 依托单位: CARNEGIE-MELLON UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2008
• 资助国家: 美国
• 起止时间: 2008-08-01 至 2009-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7723380
• 关键词: Adult; Allografting; Computer Retrieval of Information on Scientific Projects Database; Disease Progression; Distress; Funding; Genomics; Grant; Human; Immunosuppressive Agents; Institution; Kidney; Kidney Diseases; Kidney Transplantation; Pharmaceutical Preparations; Play; Research; Research Personnel; Resources; Role; Source; Structure; Tissues; Transplant Recipients; United States National Institutes of Health; Viral; Virus; kidney allograft

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Polymavirus is latent in the kidney of up to 50% of healthy adults. In kidney transplant patients maintained on immunosuppressive drugs, reactivation of virus can result in polymovirus allograft nephropathy (PVAN). PVAN is an inadequately studied and distressing condidtion that frequently leads to graft loss. The study being proposed explores the notion that changes in viral genomic structure might play an important role in the initiation and subsequent progression of this disease

该子项目是利用该技术的众多研究子项目之一 资源由 NIH/NCRR 资助的中心拨款提供。子项目及 研究者 (PI) 可能已从 NIH 的另一个来源获得主要资金， 因此可以在其他 CRISP 条目中表示。列出的机构是 对于中心来说，它不一定是研究者的机构。 多瘤病毒潜伏在高达 50% 的健康成年人的肾脏中。在持续服用免疫抑制药物的肾移植患者中，病毒重新激活可导致多病毒同种异体移植肾病（PVAN）。 PVAN 是一种研究不足且令人痛苦的疾病，经常导致移植物丢失。拟议的研究探讨了病毒基因组结构的变化可能在这种疾病的发生和随后的进展中发挥重要作用的概念