Predictors of Alcohol Recovery and Relapse Among Female Drunk Drivers

女性醉酒司机酒精恢复和复发的预测因素

• 批准号: 7869409
• 负责人: VIVIA V MCCUTCHEON
• 金额: $ 12.15万
• 依托单位: WASHINGTON UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2009
• 资助国家: 美国
• 起止时间: 2009-06-10 至 2014-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7869409
• 关键词: Aftercare; Alcohol abuse; Alcohol consumption; Alcohol dependence; Alcoholism; Alcohols; Behavioral; Child; Clinical; Clinical Treatment; Data; Data Analyses; Data Collection; Dependence; Disease remission; Drug usage; Enrollment; Environment; Environmental Exposure; Environmental Risk Factor; Equation; Family; Family Study; Female; Generations; Genes; Genetic; Goals; Individual; Instruction; Knowledge; Measures; Mental disorders; Mentored Research Scientist Development Award; Mentors; Modeling; Molecular Genetics; Outcome; Parent-Child Relations; Parents; Pattern; Phenotype; Physiological; Population; Psychiatry; Recording of previous events; Recovery; Relapse; Research; Research Training; Sampling; Severities; Symptoms; Training; Trauma; Twin Multiple Birth; Universities; Washington; Woman; Work; alcohol research; alcohol use disorder; career; design; drinking; driving under influence; experience; genetic epidemiology; genetics of alcoholism; help-seeking behavior; high risk; improved; men; offspring; older women; psychogenetics; research study; skills; treatment program

DESCRIPTION (provided by applicant): This Mentored Research Scientist Development Award will prepare the Candidate for career goals focused on the interplay of genetic and environmental factors as they influence remission and relapse among women with alcohol use disorders and the course of alcohol and drug use among their offspring. The Candidate's immediate career goals are to: (1) become proficient in designing and conducting clinical, including observational, research, (2) gain knowledge of genetic influences on alcohol use disorders and training in molecular genetics, (3) define alcohol use phenotypes and associated environmental measures for use in examining genetic and environmental influences on recovery and relapse among women, and (4) develop advanced quantitative skills in statistical genetics and structural equation modeling. The research plan is designed to characterize patterns of alcohol use and to examine predictors of remission and relapse among women with severe alcohol use disorders, in secondary analysis of data from a high-risk family study of alcoholism (Collaborative Study on the Genetics of Alcoholism [COGA]) and in new data to be collected from women with convictions for driving under the influence of alcohol (DUI). New data collection will provide the Candidate with experience in engaging in research a population that is historically difficult to locate and retain, an important first step towards the long-term goal of enrolling offspring and collecting DMA. Alcohol use phenotypes and environmental influences which can maximize the ability to examine gene-environment interplay as it influences women's remission and relapse will be defined through careful integration of the research and training plans, utilizing new data and secondary analysis of data from COGA and from twin samples available through the Midwest Alcoholism Research Center. The Washington University Department of Psychiatry and the Midwest Alcoholism Research Center provide a training environment with access to mentors with expertise in psychiatric genetic epidemiology and statistical and molecular genetics. In addition, the Candidate has enlisted the help of co-mentors with expertise in clinical and treatment research and in working with DUI populations. RELEVANCE (See instructions): Alcohol dependence among women has profound consequences on women and on their children. There is evidence that today's young women are more likely to become dependent on alcohol than women of older generations, yet most alcohol research is focused on men. This research study will focus specifically on women to better understand how environmental and genetic factors contribute to women's alcohol use and to their recovery, and to improved outcomes for them and their children.

描述（由申请人提供）：这项受过指导的研究科学家发展奖将为候选人做好准备的候选人，该目标的重点是遗传和环境因素的相互作用，因为它们会影响饮酒障碍的妇女的缓解和复发，以及其后代中酒精和吸毒的过程。候选人的直接职业目标是：（1）熟练地设计和进行临床，包括观察性，研究，（2）获得对遗传影响的知识，对酒精使用障碍的影响以及分子遗传学的培训以及分子遗传学的培训，（3）定义酒精使用表型以及在研究遗传和环境中使用统计和统计量的相关环境测量，并（4）对女性的统计和统计的影响，（4）建模。该研究计划旨在表征饮酒的模式，并检查严重酒精使用障碍的女性的缓解和复发的预测因素，在对酒精中毒的高风险家庭研究的次要分析中（关于酒精中毒[COGA]的遗传学[COGA]的合作研究），以及在妇女受到驾驶的妇女驾驶影响（DUI）受到定罪的新数据中。 新的数据收集将为候选人提供研究经验，从而从历史上很难找到和保留研究，这是朝着加入后代和收集DMA的长期目标的重要第一步。酒精使用表型和环境影响，可以通过仔细整合研究和培训计划，利用COGA和来自中西部酒精研究中心可用的TWIN样品的数据分析，通过仔细整合研究和培训计划来最大程度地检查基因 - 环境相互作用的能力，从而影响妇女的缓解和复发。华盛顿大学精神病学系和中西部酒精中毒研究中心提供了一个培训环境，并可以访问具有精神病遗传流行病学和统计和分子遗传学专业知识的导师。此外，候选人还获得了在临床和治疗研究方面以及与DUI人群合作方面具有专业知识的联合学者的帮助。相关性（请参阅说明）：妇女的酒精依赖对妇女及其子女产生了深远的影响。有证据表明，今天的年轻女性比老一辈的妇女更有可能依赖酒精，但是大多数酒精研究都集中在男性上。这项研究将专门针对女性，以更好地了解环境和遗传因素如何促进妇女的饮酒和康复，并改善她们及其子女的结果。