Comparative Effects of Two Popular Diets in Veterans with the Metabolic Syndrome

两种流行饮食对患有代谢综合征的退伍军人的比较效果

• 批准号: 7685198
• 负责人: MICHAEL MILLER
• 金额: --
• 依托单位: BALTIMORE VA MEDICAL CENTER
• 依托单位国家: 美国
• 财政年份: 2009
• 资助国家: 美国
• 起止时间: 2009-04-01 至 2013-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7685198
• 关键词: Acute; Adipose tissue; Aerobic; Aerobic Exercise; Antioxidants; Area; Atherosclerosis; Biochemical; Blood Pressure; Blood Vessels; Body Composition; Body Weight; Body Weight decreased; CETP gene; Cardiovascular Diseases; Cardiovascular system; Cause of Death; Clinical Trials; Complex; Data; Diet; Diet Modification; Dietary Fats; Dual-Energy X-Ray Absorptiometry; Dyslipidemias; Endothelium; Enzymes; Evaluation; Event; Exercise; Family member; Fatty Acids; General Population; Glucose; Health; Health Benefit; Healthcare; High Density Lipoproteins; Homeostasis; Impairment; Incidence; Insulin; Insulin Resistance; Investigation; Laboratories; Lead; Life Style; Lifestyle Therapy; Lipid Peroxidation; Lipids; Lipoproteins; Long-Term Effects; Mediating; Mediterranean Diet; Metabolic; Metabolic syndrome; Mission; Modeling; Monounsaturated Fatty Acids; Non-Insulin-Dependent Diabetes Mellitus; Obesity; Patients; Physical activity; Physiological; Polyunsaturated Fatty Acids; Population; Prevalence; Property; Proteins; Recommendation; Regimen; Research; Rest; Risk; Risk Factors; Structure; Testing; Therapeutic; United States Dept. of Health and Human Services; Unsaturated Fats; Vasodilation; Veterans; Visceral; Walking; Weight; Weight maintenance regimen; Woman; X-Ray Computed Tomography; adiponectin; brachial artery; cardiovascular disorder risk; comparative; design; diabetic; diet and exercise; disorder prevention; fasting glucose; fitness; good diet; improved; inflammatory marker; interest; lipid transfer protein; men; monounsaturated fat; news; polyunsaturated fat; programs; public health relevance; response; saturated fat; waist circumference

DESCRIPTION (provided by applicant): The Metabolic Syndrome (MetS) is a common problem among Veterans and is associated with a greater likelihood of cardiovascular disease (CVD). The Mediterranean diet is the only popular diet that has been shown to reduce CVD event rates but the extent to which monounsaturated fatty acid (MUFA) or polyunsaturated fatty acid (PUFA) enrichment results in improvement in parameters of MetS is unresolved. Similarly, while low intensity exercise improves the CVD risk factor profile, there have been no comparative investigations comparing MUFA and PUFA enriched diets and exercise in patients with MetS that have extended beyond 1 year. Recently, the VA established the MOVE! program, a national weight management program designed to help Veterans lose weight. Using the VA promoted program, we will perform a systematic evaluation of the effects of dietary fat composition [comparison between MUFA-enriched and PUFA enriched diet] with MOVE!. We hypothesize that a MUFA-enriched diet consisting of antioxidant, lipid reducing and insulin sensitizing properties will be superior to the less palatable PUFA- enriched diet on improving cardiometabolic parameters associated with MetS. Specifically, the MUFA MOVE! program is expected to lead to greater improvements than the PUFA MOVE! program in body composition and aerobic fitness (Specific Aim 1), endothelial dependent flow mediated vasodilation and the postprandial lipid response to a meal load (Specific Aim 2) and the mechanisms (lipolytic and lipid transfer protein activity, homeostasis model assessment-estimated insulin resistance) responsible for these effects (Specific Aim 3). Collectively, these studies will advance our understanding of mechanisms underlying the differential effects of MUFA and PUFA-enriched dietary regimens on cardiometabolic health and when combined with the MOVE! program, will provide new and useful information to Veterans (and the general public) interested in optimizing their diets for CVD disease prevention and improved vascular health. PUBLIC HEALTH RELEVANCE: Potential Impact on Veterans Health Care: According to a VA news release dated February 27, 2006, of the 7.5 million veterans receiving health benefits, more than 70% are obese and 20% are diabetic, which is considerably higher compared to the general U.S. population where the prevalence of DM approximates 7%. In view of these concerns, the VA and Department of Health and Human Services (HHS) have embarked on a coordinated campaign to educate veterans and family members about the importance of attaining a healthier diet and lifestyle. In addition to dietary modification aimed at weight loss and improving biochemical and physiologic parameters of MetS, this proposal will also utilize the MOVE! program, a national weight management program designed by the VA in an effort to coordinate diet with daily walking to reduce body weight and improve cardiovascular health. Therefore, this proposal has direct relevance to the VA health care mission.

描述（由申请人提供）： 代谢综合征（METS）是退伍军人的常见问题，与心血管疾病（CVD）的可能性更大有关。地中海饮食是唯一已显示可降低CVD事件发生率的流行饮食，但单不饱和脂肪酸（MUFA）或多不饱和脂肪酸（PUFA）富集的程度尚未解决，从而改善了MetS参数的改善。同样，虽然低强度运动改善了CVD风险因素的特征，但在比较MUFA和PUFA富含饮食和运动的MetS患者中，尚无比较研究。最近，弗吉尼亚州建立了此举！计划是一项国家体重管理计划，旨在帮助退伍军人减肥。使用VA促进的计划，我们将对饮食脂肪组成的影响进行系统评估[MUFA富集和PUFA富含饮食之间的比较]，然后进行！我们假设通过抗氧化剂，脂质还原和胰岛素敏化特性组成的MUFA富集饮食将优于不太可口的PUFA富含PUFA的饮食，以改善与Mets相关的心脏代谢参数。具体来说，Mufa移动！预计计划将带来比PUFA举动更大的改进！人体组成和有氧健身的计划（特定目标1），依赖于内皮的流动介导的血管扩张以及餐后脂质对饮食负荷的反应（特定目标2）和机制（脂质和脂质转移蛋白活性，稳态和稳态模型估计估计的胰岛素抵抗）对这些效果负责（特定目标3）。总的来说，这些研究将提高我们对MUFA和PUFA富含饮食方案对心脏代谢健康以及与此移动相结合的饮食方案的差异影响的理解的理解！计划将为有兴趣优化其预防CVD疾病饮食和改善血管健康的退伍军人（以及公众）提供新的有用信息。 公共卫生相关性： 对退伍军人卫生保健的潜在影响：根据2006年2月27日的VA新闻发布，在获得健康福利的750万退伍军人中，有70％以上是肥胖，糖尿病为20％，与DM大约7％的美国普通人群相比，这一比例高得多。鉴于这些担忧，弗吉尼亚州和卫生与公共服务部（HHS）已经开始了一项协调一致的运动，以教育退伍军人和家庭成员，以了解获得更健康的饮食和生活方式的重要性。除了饮食修改还旨在减肥并改善Met的生化和生理参数外，该提案还将利用这一举动！计划是由VA设计的全国体重管理计划，旨在协调饮食，每天步行以减轻体重并改善心血管健康。因此，该提案与VA医疗保健任务有直接相关。