RR&D Research Career Scientist Award Application

RR

• 批准号: 10426424
• 负责人: ALICE S. RYAN
• 金额: --
• 依托单位: BALTIMORE VA MEDICAL CENTER
• 依托单位国家: 美国
• 财政年份: 2022
• 资助国家: 美国
• 起止时间: 2022-07-01 至 2029-06-30
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10426424
• 关键词: Acute; Adipose tissue; Advocate; Aerobic Exercise; Affect; Aging; American; Appointment; Atrophic; Attitude; Award; Baltimore; Blood Vessels; Body Weight decreased; Breast; COVID-19; Capsicum; Cardiovascular system; Caring; Catastrophic Illness; China; Chronic; Chronic Disease; Clinical; Clinical Investigator; Clinical Sciences; Collaborations; Communicable Diseases; Development; Diabetes Mellitus; Discipline; Disease; Doctor of Medicine; Doctor of Philosophy; Education; Elderly; Endothelium; Energy Metabolism; Environment; Epigenetic Process; Event; Exercise; Exercise Physiology; Exercise Therapy; Fatty acid glycerol esters; GDF8 gene; Geriatrics; Gerontology; Goals; Grant; Guidelines; HIV; HIV Infections; Health; Health Personnel; Health Promotion; Healthcare Systems; Hyperinsulinism; Impairment; Infiltration; Inflammation; Insulin Resistance; Intermittent fasting; International; Intervention; Intervention Trial; Intramuscular; Investigation; K-Series Research Career Programs; Knowledge; Leadership; Life Style; Limb structure; Link; Lung; Malignant Neoplasms; Maryland; Medical; Medical Students; Medicine; Mentors; Metabolic; Mission; Mitochondria; Molecular; Multi-Institutional Clinical Trial; Muscle; Muscle Development; Muscle Fibers; Muscular Atrophy; Musculoskeletal System; Nature; Neurology; Non-Insulin-Dependent Diabetes Mellitus; Nutritional Support; Obesity; Oncology; Operative Surgical Procedures; Oxidative Stress; Palliative Medicine; Paresis; Peripheral arterial disease; Persons; Physical Medicine; Physical activity; Physical therapy; Physicians; Play; Population; Positioning Attribute; Postdoctoral Fellow; Prevalence; Preventive Medicine; Process; Protein Biosynthesis; Proteins; Pulmonology; Race; Radiology Specialty; Recommendation; Recording of previous events; Rehabilitation therapy; Reporting; Research; Research Personnel; Rheumatology; Risk; Risk Reduction; Robotics; Role; Science; Scientist; Seminal; Services; Side; Skeletal Muscle; Stroke; Supplementation; Testing; Thigh structure; Time; Tissues; Training; Training Programs; Translating; United States; United States Department of Veterans Affairs; United States National Institutes of Health; Universities; Veterans; Work; base; bench to bedside; body system; cardiorespiratory fitness; cardiovascular fitness; career; clinical center; comorbidity; deconditioning; design; disability; evidence base; exercise rehabilitation; exercise training; flexibility; frontier; functional independence; functional restoration; hemiparetic stroke; improved; innovation; insulin sensitivity; interest; medical schools; member; military veteran; mode of exercise; muscle hypertrophy; muscle metabolism; nervous system disorder; next generation; novel; nutrition; patient oriented; patient oriented research; patient population; post stroke; prevent; rehabilitation paradigm; rehabilitation research; rehabilitation science; rehabilitation strategy; research and development; sarcopenia; stroke rehabilitation; stroke survivor; symposium; tele-exercise; weight maintenance

My research focuses on developing and testing interventions to restore function and minimize disability following acute disabling events and to prevent declines related to serious chronic diseases. In addition, my work aims to advance our understanding of the mechanisms by which exercise and rehabilitation interventions directed at specific impairments affect body systems and tissues. My passion is also to train the next generation of investigators who will further the understanding of the aging process and develop interventions that help promote health and independence in older adults with disabling medical conditions. My work aligns well with the mission of Rehabilitation Research & Development (RR&D) and renewal of this Senior Research Career Scientist Award will allow me to continue this path. My entire career has been within the VA Maryland Health Care System with my first VA Merit awarded in 2001 Clinical Science Research & Development (CSR&D) and appointment as a VA Research Scientist, receipt of a NIH RO1 in 2001, and award of the Research Career Scientist (RCS) within CSR&D in 2004. During the first 5-years of the RCS, I was awarded a second VA Merit (CSR&D), a second NIH/RO1, and played an integral role in the receipt of three center grants where I was PI or co-investigator on research cores. During years 5-10 of the RCS, I obtained a third VA Merit (RR&D), a Merit Pilot Award (RR&D), was a co-investigator on four VA Merit Awards (CSR&D and RR&D), five NIH RO1 grants, two NIH-R awards, and led cores in three center grants. I was awarded a fourth VA Merit (RR&D) in 2015. During the SRCS which began in 2015, I was awarded a VA SPiRE (RR&D) in 2018, and fifth and sixth VA Merit Awards in 2019 and 2020 in RR&D and CSR&D, respectively. I was also awarded or a co-investigator on multiple NIH projects during this past cycle. I will be MPI in the renewal of the University of Maryland (UM) Claude D. Pepper Older Americans Independence Center (OAIC). My research career has thrived in this enriched research environment in collaboration with Veterans Affairs and University of Maryland M.D. and Ph.D. investigators. My leadership, independence, collegial attitude and collaborative nature serve to promote innovative patient-oriented research in preventive medicine, exercise rehabilitation, nutrition and aging in the VA Research Service, Baltimore GRECC, UM-OAIC, the Division of Gerontology and Palliative Medicine and in the past for the VA RR&D Center of Excellence, Exercise and Robotics in Neurological Disease and the Mid-Atlantic Nutrition and Obesity Research Center. I have enjoyed more recent opportunities to conduct multi-site clinical trials which further strengthen and expand the science in our goals to maximize independence in aging Veterans. I hold leadership positions within the Geriatrics, Research, Education & Clinical Centers (GRECC), have been a long-standing member of local VA committees (R&D and SRS), am a 13-year member of the Medicine Appointment, Promotions, Tenure (APT) Committee at UM, and have a continuous track record as member and chair of VA and NIH review panels. In my leadership positions, I promote and assist investigators in combined exercise and rehabilitation medicine interventions to examine changes in the cardiovascular and musculoskeletal systems and the link to function and mobility. Further, I have a successful history of training of junior scientists in becoming independent academic careers in exercise and rehabilitation science as a primary mentor of numerous postdoctoral fellows and upon receipt of their VA CDA or NIH K-Award. My commitment and joy in mentoring medical students, fellows and junior investigators in rehabilitation research continues to grow. I am indeed fortunate to have collaborators which cross so many disciplines including gerontology, exercise physiology, infectious disease, neurology, oncology, physical therapy, vascular surgery, radiology, pulmonology, and rheumatology. I am honored to have received the Senior Research Career Scientist and greatly appreciate the opportunity to renew this prestigious award.

我的研究重点是制定和测试干预措施以恢复功能并最大程度地减少残疾 急性禁用事件并防止与严重慢性疾病有关的下降。此外，我的工作 旨在促进我们对锻炼和康复干预措施的机制的理解 针对特定障碍会影响人体系统和组织。我的热情也是训练下一代 调查人员将进一步了解老化过程并制定干预措施以帮助 促进患有医疗状况的老年人的健康和独立性。我的工作与 康复研究与发展的使命（RR＆D）以及该高级研究职业的更新 科学家奖将使我能够继续这条道路。 我的整个职业生涯一直在VA马里兰州的医疗保健系统中 2001年临床科学研发（CSR＆D），并任命为VA研究科学家，收据 2001年的NIH RO1，并在2004年CSR＆D内授予研究职业科学家（RCS）。 RCS的前5年，我获得了第二个VA功绩（CSR＆D），第二个NIH/RO1，并播放了不可或缺的 在收到三个中心补助金的角色中，我在研究核心上是PI或共同投资者。在5 - 10年中 在RCS中，我获得了第三个VA功绩（RR＆D），是优异的飞行员奖（RR＆D），是四个VA的共同投资者 优异奖（CSR＆D和RR＆D），五项NIH RO1补助金，两个NIH-R奖项以及三项中心赠款的LED核心。 2015年，我被授予第四名VA功绩（RR＆D）。在2015年开始的SRCS期间，我被授予VA 2018年的Spire（RR＆D），2019年的第五和第六VA优异奖和2020年的RR＆D和CSR＆D， 分别。在过去的周期中，我还获得了多个NIH项目的共同研究。我会成为MPI 在马里兰州大学（UM）Claude D. Peper老年人独立中心的续签中 （OAIC）。我的研究生涯在与退伍军人合作中在这个丰富的研究环境中蓬勃发展 事务和马里兰大学医学博士和博士学位调查人员。我的领导，独立性，联合态度 和协作性的性质有助于促进创新的面向患者的预防医学研究，锻炼 巴尔的摩Grecc，UM-OAIC的VA研究服务中的康复，营养和衰老， 老年医学和姑息医学以及VA RR＆D卓越，运动和 神经系统疾病和中大西洋营养与肥胖研究中心的机器人技术。我很喜欢 最新的机会进行多站点临床试验，以进一步加强和扩大科学 我们的目标是最大化老年退伍军人的独立性。 我在老年医学，研究，教育和临床中心（GRECC）中担任领导职务 一直是当地VA委员会（R＆D和SRS）的长期成员，是该药物的13年成员 在UM任命，晋升，任期（APT）委员会，并具有成员的持续记录和 VA和NIH评论面板主席。在我的领导职务中，我促进和协助调查人员合计 运动和康复医学干预措施以检查心血管和肌肉骨骼的变化 系统以及功能和移动性的链接。此外，我有一个成功的初级科学家培训的历史 成为运动和康复科学领域的独立学术职业，作为 许多博士后研究员，并收到他们的VA CDA或NIH K-award。我的承诺和喜悦 指导医学生，研究员和初级调查人员的康复研究继续增长。 我确实很幸运有合作者跨越许多学科，包括老年医学， 运动生理学，传染病，神经病学，肿瘤学，物理治疗，血管外科，放射学，放射学， 肺病学和风湿病学。我很荣幸获得了高级研究职业科学家和 非常感谢有机会续签这一享有盛誉的奖项。