Applied Physiology and Tissue Mechanisms

应用生理学和组织机制

• 批准号: 9170580
• 负责人: ALICE S. RYAN
• 金额: $ 19.28万
• 依托单位: UNIVERSITY OF MARYLAND BALTIMORE
• 依托单位国家: 美国
• 财政年份: 2006
• 资助国家: 美国
• 起止时间: 2006-09-15 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/9170580
• 关键词: Acute; Adipose tissue; Aerobic; Aging; American; Biological Assay; Biomedical Research; Capsicum; Cardiovascular Deconditioning; Cardiovascular system; Chronic; Chronic Disease; Chronic Kidney Failure; Clinical; Clinical Trials; Collaborations; Communities; Development; Elderly; Eligibility Determination; Endocrine; Ensure; Event; Exercise; Exercise stress test; Faculty; Functional disorder; Funding; Gene Expression; Grant; HIV-1; Hip Fractures; Impairment; Individual; Inflammation; Insulin Resistance; Intervention; Leadership; Maryland; Medical; Mentors; Metabolic; Metabolic syndrome; Metabolism; Methodology; Molecular; Muscle; Musculoskeletal; Obesity; Outcome; Paper; Parkinson Disease; Patient Recruitments; Performance; Peripheral arterial disease; Physical Function; Physiological; Physiology; Pilot Projects; Population; Prevention; Prevention strategy; Preventive; Proteins; Protocols documentation; Publications; Rehabilitation therapy; Research; Research Personnel; Research Support; Resistance; Resources; Risk; Scientist; Skeletal Muscle; Stroke; System; Testing; Tissues; Training; Translating; Translational Research; Translations; United States National Institutes of Health; Universities; Vascular Endothelium; Work; base; bench to bedside; cardiometabolic risk; cardiovascular disorder risk; clinical phenotype; design; diabetes risk; disability; disabling disease; disorder risk; exercise intervention; exercise rehabilitation; exercise training; falls; fitness; functional decline; improved; innovation; laboratory experience; metabolic phenotype; mode of exercise; multidisciplinary; muscular structure; novel; patient safety; programs; rehabilitation science; rehabilitation strategy; research and development; research study; response; restoration; sarcopenia; screening; volunteer; working group

7. Project Summary- Resource Core 2 Cardiovascular deconditioning, chronic inflammation, and endocrine-metabolic dysfunction are inherent to the pathophysiology of the physical impairments in older persons hindered by disabling chronic diseases of aging. Sarcopenia, poor fitness, inflammation, and acute events causing disability -- such as falls, stroke, and hip fracture -- occur with advancing age and may worsen mobility and increase risk for cardiovascular disease (CVD) and metabolic abnormalities. The Applied Physiology and Tissue Mechanisms Resource Core’s (RC-2) hypothesis is that exercise and activity-based rehabilitation can improve multiple physiological systems in older, mobility-limited individuals, leading to improved functional performance, reduced cardiometabolic disease risk, and prevention of functional decline. This core focuses on the following specific aims: 1)To facilitate the conduct of musculoskeletal and tissue mechanistic exercise rehabilitation and preventive biomedical research in aging and disability across the UM-OAIC pilot projects, UM-OAIC scholars’ research, Development Projects (DPs), and external NIH and VA funded research; and 2)To provide research support, mentoring, and training to UM-OAIC scholars, junior faculty, and UM-OAIC researchers in the performance of aging research relevant to exercise and rehabilitation-based restoration of function and the prevention of functional declines in older people with chronic disabling diseases. RC-2 leadership and investigators represent a multidisciplinary team of basic scientists with clinical geriatricians who have worked together for 15-20 years. The characterization of the clinical and metabolic phenotype(s) of individuals with stroke, hip fracture, and other chronic disabling diseases in RC-2 have allowed UM-OAIC investigators to develop successful specific exercise rehabilitation strategies to improve functional and clinical outcomes. Thus this core, in collaboration with the other UM-OAIC cores, will continue to support innovative research studies examining the mechanisms and physiological effects of multisystem rehabilitation and preventive strategies on functional and physiological outcomes in older adults aging with chronic disabilities, with translation of these outcomes in novel clinical trials.

7。项目摘要 - 资源核心2 心血管调节，慢性炎症和内分泌功能障碍是继承的 老年人的身体障碍的病理生理学因禁用慢性疾病而阻碍的老年人。 肌肉减少症，健身不良，炎症和急性事件，导致残疾 - 例如跌倒，中风和臀部 骨折 - 随着年龄的增长而发生，可能会降低流动性并增加心血管疾病的风险 （CVD）和代谢异常。应用生理和组织机制资源核心（RC-2） 假设是，基于运动和基于活动的康复可以改善多个物理系统 较旧的，迁移率有限的个体，可提高功能性能，降低心脏代谢 疾病风险，预防功能下降。该核心侧重于以下特定目的：1） 促进肌肉骨骼和组织机械运动康复和预防性的行为 UM-OAIC试点项目衰老和残疾的生物医学研究，UM-OAIC学者的研究， 开发项目（DPS）以及外部NIH和VA资助的研究； 2）提供研究支持， 指导和对UM-OAIC学者，初级教师和UM-OAIC研究人员进行培训 与基于运动和康复的功能恢复有关的衰老研究和预防 患有慢性残疾疾病的老年人的功能下降。 RC-2领导力和研究人员代表了一个跨学科的基础科学家团队 共同工作15至20年的老年医生。临床和代谢的表征 RC-2中的中风，髋部骨折和其他慢性残疾疾病的表型已允许 UM-OAIC的研究人员开发成功的特定锻炼康复策略以提高功能 和临床结果。该核心与其他UM-OAIC核心合作将继续支持 创新研究研究了多系统康复的机制和物理影响 以及有关老年人衰老的慢性老年人功能和身体结果的预防策略 残疾，在新型临床试验中翻译这些结果。