Hybrid-FES Exercise to Attenuate Increased Central Adiposity andImprove Glucoregulatory Control in Acute SCI

混合 FES 运动可减轻急性 SCI 中中心性肥胖的增加并改善血糖调节控制

• 批准号: 10389010
• 负责人: Matthew R Ely
• 金额: $ 7.01万
• 依托单位: SPAULDING REHABILITATION HOSPITAL
• 依托单位国家: 美国
• 财政年份: 2022
• 资助国家: 美国
• 起止时间: 2022-03-01 至 2025-02-28
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10389010
• 关键词: Acute; Adipose tissue; Aerobic; Aerobic Exercise; Attenuated; Award; Blood; Blood Glucose; Body Composition; Buspirone; Cardiopulmonary; Cardiovascular Diseases; Cardiovascular system; Cohort Studies; Data; Dual-Energy X-Ray Absorptiometry; Enrollment; Exercise; Fasting; Fatty acid glycerol esters; Fellowship; Funding; Gene Expression; Glucose tolerance test; Glycosylated hemoglobin A; Health; Hybrids; Impairment; Individual; Insulin; Intervention; Lead; Leg; Leptin; Lung; Mechanics; Metabolic; Metabolic stress; Morbidity - disease rate; Movement; Muscular Atrophy; National Research Service Awards; Non-Insulin-Dependent Diabetes Mellitus; OGTT; Obesity; Paralysed; Participant; Pharmacologic Substance; Physiological; Placebos; Population; Prevalence; Production; Prospective Studies; Protocols documentation; Regimen; Rehabilitation therapy; Research; Research Personnel; Research Training; Retrospective Studies; Risk; Serotonin Agonists; Serum; Skeletal Muscle; Spinal cord injury; Techniques; Thinness; Tissues; Training; Training Programs; Transforming Growth Factor Beta 2; Visceral; Visceral fat; Work; adipokines; arm; base; blood glucose regulation; cardiovascular disorder risk; cardiovascular risk factor; cohort; energy balance; exercise intensity; exercise training; fasting plasma glucose; follow-up; functional electrical stimulation; glucose metabolism; improved; insulin sensitivity; long-term rehabilitation; metabolic profile; mortality risk; murine nodule inducing virus; muscle form; prevent; programs; reduced muscle mass; rehabilitation strategy; resistin; response; sedentary activity; standard of care; ventilation

ABSTRACT / PROJECT SUMMARY This postdoctoral F32 Kirschstein NRSA proposes unique research and includes a comprehensive training plan in the study of functional electrical stimulation row training (FESRT) as a rehabilitation technique in individuals with spinal cord injuries (SCI). Individuals with spinal cord injuries have a greater morbidity and mortality risk from cardiovascular disease (CVD) than able-bodied individuals. The increased risk could be due, in part, to increased fat mass or dysregulated adipokine production leading to an impaired glucoregulatory control as a result of muscle atrophy and increased sedentary activity. Functional electrical stimulation (FES) exercise is increasingly being used in the acute and long-term rehabilitation of individuals with spinal cord injuries. Our lab uses this technique to induce leg extension and flexion in combination with voluntary upper body movements allowing for whole body rowing (FESRT). This exercise, incorporated into a 6-month training regimen, has been shown to increase aerobic fitness, attenuate gains in fat and loss of paralyzed muscle mass, and control blood glucose; hence, decreasing risk for CVD. However, there is currently a lack of information concerning retention of exercise training adaptations in those with SCI. Therefore, we propose a retrospective study to analyze body composition, adipose tissue adipokine production, serum adipokine concentrations, and glucoregulatory control in a group of individuals with SCI (n=31) who participated in 6 months of FESRT and either continued training (n=15) or returned to standard of care (n=16) (AIM 1). Additionally, these beneficial adaptations to FESRT may be proportional to exercise training intensity. Pulmonary limitations in SCI likely limit the attainment of sustainably vigorous FESRT exercise intensities. Therefore, we plan on studying changes in body composition, adipose tissue adipokine production, serum adipokine concentrations, and glucoregulatory control in relation to exercise training intensity in a prospective study that incorporates mechanical (non-invasive ventilation) and pharmaceutical (serotonin receptor agonist) ergogenic aids to increase ventilatory capacity (AIM 2). The ultimate purpose of this research is to optimize exercise training protocols for a population that both needs and seeks a broad range of benefits that exercise can confer. This F32 postdoctoral fellowship research and training plan will help develop and optimize rehabilitation strategies in individuals with spinal cord injuries and prepare me to advance as an independent researcher.

摘要 /项目摘要 这项博士后F32 Kirschstein NRSA提出了独特的研究，包括 功能电刺激行训练（FESRT）研究中的全面训练计划（FESRT） 作为脊髓损伤患者（SCI）的康复技术。脊柱的个体 绳索损伤比心血管疾病（CVD）具有更大的发病率和死亡风险 身体健全的人。风险增加可能部分是由于脂肪质量增加或 由于脂肪因子的失调，导致糖调节控制受损 肌肉萎缩并增加久坐活性。功能电刺激（FES） 运动越来越多地用于个人的急性和长期康复 脊髓损伤。我们的实验室使用此技术诱导腿部伸展和屈曲 结合自愿的上半身运动，可以进行全身划船（FESRT）。 该练习已纳入6个月的培训方案，已显示出增加 有氧运动，脂肪的衰减和瘫痪的肌肉质量的损失以及控制血液 葡萄糖;因此，降低了CVD的风险。但是，目前缺乏信息 关于在SCI患者中保留运动训练适应。因此，我们提出了一个 回顾性研究以分析人体组成，脂肪组织脂肪因子的产生，血清 一组SCI个体的脂肪因子浓度和葡萄糖调节控制（n = 31） 参加了6个月的FESRT并继续培训（n = 15）或返回 护理标准（n = 16）（目标1）。此外，这些对FESRT的有益改编可能是 与运动训练强度成正比。 SCI的肺部限制可能会限制 可持续发展的FESR锻炼强度。因此，我们计划研究变化 身体成分，脂肪组织脂肪因子产生，血清脂肪因子浓度和 在一项前瞻性研究中，与运动训练强度有关的葡萄糖调节控制 结合机械（非侵入通气）和药物（5-羟色胺受体 激动剂）细胞生成辅助工具以增加通气能力（AIM 2）。最终目的 研究是为了优化需要并寻求一个人群的运动培训方案 运动可以授予的广泛好处。这项F32博士后奖学金研究和 培训计划将有助于制定和优化脊柱患者的康复策略 绳索受伤，并为我做好准备，成为一名独立研究人员。