Models Core

模型核心

• 批准号: 7595334
• 负责人: Fiona Claire Hankenson
• 金额: $ 17.7万
• 依托单位: UNIVERSITY OF PENNSYLVANIA
• 依托单位国家: 美国
• 财政年份: 2009
• 资助国家: 美国
• 起止时间: 2009-07-01 至 2014-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7595334
• 关键词: Animal Model; Arts; Biological; Breeding; Cardiovascular Diseases; Clinical; DNA Viruses; Development; Evaluation; Faculty; Gene Transfer; Instruction; Laboratory Animal Medicine; Laboratory Animals; Maintenance; Modeling; Monkeys; Mus; Procedures; Regulatory Affairs; Safety; Sampling; Therapeutic Studies; Universities; Veterinarians; animal facility; animal resource; gene therapy; nonhuman primate; pre-clinical; professor; programs; research study; vector

Core C - Animal Models Core The Gene Therapy Program has access to animal facilities of importance to this P01. Dr. Wilson has managed mouse and nonhuman primate vivaria at Penn for the last 14 years. These facilities are state- of-the-art, are operated under BSL2 and are AAALAC accredited. The University Laboratory Animal Resources (ULAR) provides clinical veterinarian support to both vivaria. The nonhuman primate facility is dedicated to Dr. Wilson's use, while the mouse vivarium was developed for the use of those faculty involved in gene therapy research. Dr. Claire Hankenson, (Assistant Professor of Laboratory Animal Medicine, Dept of Pathobiology and Senior Associate Director for Regulatory Affairs and Planning, ULAR) will serve as Director of the Core. The mouse oncogenicity study will be performed in a dedicated room within the mouse facility. All nonhuman primate experiments will be implemented by the Core with biological samples being provided to the Projects and other Cores. The Core will also provide support for all mouse procedures and maintenance of all breeding colonies. Lay description. A critical step in the pre-clinical development of gene therapy is the evaluation of the safety and efficacy of gene transfer in monkeys. This Core will perform these studies on behalf of the projects. RELEVANCE (See instructions):

核心C-动物模型核心 该基因治疗计划可以使用该P01重要性的动物设施。威尔逊博士有 在过去的14年中，宾夕法尼亚州托管老鼠和非人类的Primate Vivaria。这些设施是国家 在艺术中​​，根据BSL2运营，并获得AAALAC认可。大学实验室动物 资源（ULAR）为两个Vivaria提供临床兽医支持。非人类灵长类设施 专门用于威尔逊博士的使用，而鼠标是用于使用这些教师的 参与基因治疗研究。克莱尔·汉克森（Claire Hankenson）博士（实验室动物助理教授 医学，病理生物学系，监管事务和规划高级副主任， Ular）将担任核心主任。小鼠致癌性研究将在 鼠标设施内的专用房间。所有非人类灵长类动物实验将由 将生物样品提供给项目和其他核心的核心。核心也将提供 支持所有小鼠程序和所有育种菌落的维护。 外行描述。基因疗法临床前发展的关键步骤是评估 猴子基因转移的安全性和功效。该核心将代表 项目。 相关性（请参阅说明）：