Animal Models Core

动物模型核心

基本信息

批准号：
8376148
负责人：
Fiona Claire Hankenson
金额：
$ 19.53万
依托单位：
UNIVERSITY OF PENNSYLVANIA
依托单位国家：
美国
项目类别：
财政年份：
资助国家：
美国
起止时间：
至
项目状态：
未结题

来源：
https://reporter.nih.gov/project-details/8376148
关键词：
Accreditation Address American Animal Model Animals Autopsy Basic Science Biochemistry Biology Breeding Cancer Center Canis familiaris Cavia Censuses Clinical Clinical Trials Collaborations Containment Development Doctor of Philosophy Doctor of Veterinary Medicine Evaluation Research Faculty Family Felidae Felis catus Fellowship Foundations Fred Hutchinson Cancer Research Center Goals Grant Harvest Head Hereditary Disease Housing Human Genome IACUC Laboratories Laboratory Animal Medicine Laboratory Animals Life Location Macaca Macaca mulatta Medicine Michigan Microbiology Mission Molecular Mus Names North Carolina Oryctolagus cuniculus Paper Participant Pediatric Oncology Pennsylvania Phase Pilot Projects Play Policies Positioning Attribute Postdoctoral Fellow Primates Principal Investigator Procedures Publishing Rattus Recruitment Activity Recycling Regulatory Affairs Reporting Request for Applications Research Research Design Research Infrastructure Resources Rodent Role Running Safety Sampling Schools Science Services Toxic effect Toxicology Training Translational Research Universities Vaccines Veterinarians Visit Wages Work animal facility animal resource college cost design gene therapy human disease interest nonhuman primate operation preclinical evaluation preclinical study professor programs quality assurance research study vector

项目摘要

The Animals Models Core represents an expanded version of the former Toxicology Core. Previous work of the Core focused on animal studies to assess toxicity of vectors in support of clinical trials and basic toxicologic research in nonhuman primates. We found that the majority of the activities of this Core were directed at addressing basic research questions. We therefore have broadened the scope of the core to support the preclinical evaluation of molecular therapies in a variety of animal models and have changed the name of the core to reflect its new mission. The foundation of the Animal Models Core is the Animal Services Unit (ASU) which provides comprehensive support in a number of animal models with a focus on mice, rats, rabbits, guinea pigs and nonhuman primates. The ASU operates a rodent facility with approximately 4000 cages and a nonhuman primate facility whose census averages 50 to 60 rhesus and cynomolgus macaques. The ASU staff provides technical, husbandry, facility, clinical and enrichment support. The Nonhuman Primate Research Program works directly with faculty to design, conduct and perform experiments in nonhuman primates. This application requests resources to support technical services for rodent, rabbit, canine and feline experiments as well as partial support for pilot experiments in nonhuman primates.

动物模型核心代表了以前毒理学核心的扩展版本。以前的工作核心侧重于动物研究，以评估载体的毒性支持临床试验和基本非人类灵长类动物的毒理学研究。我们发现该核心的大部分活动是致力于解决基础研究问题。因此，我们将核心的范围扩大到支持各种动物模型中分子疗法的临床前评估，并改变了核心的名称以反映其新任务。动物模型核心的基础是动物服务单元（ASU），在许多动物模型中提供全面的支持，重点是小鼠，大鼠，兔子，豚鼠和非人类灵长类动物。 ASU与大约4000个笼子和一个非人类灵长类设施，其人口普查平均为50至60个恒河猴 cynomolgus猕猴。 ASU员工提供技术，畜牧业，设施，临床和丰富支持。非人类灵长类动物研究计划直接与教师合作，设计，行为和在非人类灵长类动物中执行实验。该应用程序请求资源支持技术啮齿动物，兔子，犬和猫实验的服务，以及对试点实验的部分支持非人类灵长类动物。