Integrating EEG/MEG and fMRI: 99-M-0172

整合 EEG/MEG 和 fMRI：99-M-0172

• 批准号: 7735209
• 负责人: Richard Coppola
• 金额: $ 14.21万
• 依托单位: NATIONAL INSTITUTE OF MENTAL HEALTH
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/7735209
• 关键词: Address; Area; Auditory; Brain; Brain Part; Brain region; COMT gene; Catechol O-Methyltransferase; Cognitive; Computer information processing; Coupling; Data; Development; Electroencephalography; Family member; Functional Magnetic Resonance Imaging; Functional disorder; Genetic; Genotype; Imaging Techniques; Investigation; Localized; Measurement; Measures; Methods; Neurons; Patients; Pattern; Phenotype; Process; Protocols documentation; Schizophrenia; Short-Term Memory; Siblings; Source; Structure; Susceptibility Gene; Task Performances; Techniques; Time; computerized data processing; improved; indexing; tool; volunteer

Development of MEG data recording and signal processing methods has been very successful. Studies of working memory tasks and auditory processing tasks have shown the ability to localize brain activation and to address issues of phasic versus tonic activity. We have also begun to investigate phenotype measures that will be applicable in many related studies and specifically the sibling project. We are now studying almost all subjects admitted thru the sibling project. MEG recording during cognitive activation has shown the ability to localize in very comparable fashion to fMRI. Specifically beta desynchronization at the cortical level has been found to agree with BOLD activation results. However, the MEG/EEG allows for temporal information not possible with other imaging techniques. Phasic relationships across brain areas have been demonstrated using advanced signal processing techniques. Our results to date show that measures of brain structure and function represent powerful tools to find susceptibility genes. Diffrerences in the degree of activation especially in frontal regions as indexed by beta desynchronization during a working memory task have been found between patients with schizophrenia compared to well siblings and normal control volunteers. Further investigation of this activation has revealed an interaction with genotype for the well studied COMT marker.

MEG数据记录和信号处理方法的开发非常成功。对工作记忆任务和听觉处理任务的研究表明，能够定位大脑激活并解决阶段性活动与补品活动的问题。我们还开始研究将适用于许多相关研究，尤其是同级项目的表型度量。现在，我们正在研究几乎所有受试者通过兄弟姐妹项目。 认知激活期间的MEG记录表明能够以与fMRI相当的方式定位。已发现皮质水平上的beta脱离同步与大胆的激活结果一致。但是，MEG/EEG允许使用其他成像技术提供时间信息。已经使用高级信号处理技术证明了整个大脑区域的阶段关系。迄今为止，我们的结果表明，大脑结构和功能的度量代表了找到易感基因的强大工具。 与兄弟姐妹和正常的对照志愿者相比，精神分裂症患者之间在工作记忆任务期间，在工作记忆任务期间通过Beta Denchronation在工作记忆任务期间通过Beta Denchronation指数的额叶区域的衍射。对这种激活的进一步研究揭示了研究良好的COMT标记与基因型的相互作用。