Special Animal Core

特殊动物核心

• 批准号: 7688362
• 负责人: SANJEEV GUPTA
• 金额: $ 15.52万
• 依托单位: ALBERT EINSTEIN COLLEGE OF MEDICINE
• 依托单位国家: 美国
• 财政年份: 2009
• 资助国家: 美国
• 起止时间: 2009-04-01 至 2014-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7688362
• 关键词: Animal Model; Animals; Attention; Biodistribution; Breeding; Cell Transplantation; Cells; Characteristics; Chronic; Consultations; Development; Disease; Experimental Designs; Functional disorder; Funding; Future; Gene Expression; Genes; Genetic; Growth; Hepatic; Hepatocyte; Liver; Liver Failure; Medicine; Metabolic; Mission; Modality; Modeling; Operative Surgical Procedures; Procedures; Radiolabeled; Research; Research Personnel; Resources; Services; Small Intestines; Stem Cell Research; Stem cells; Training; Transplanted tissue; Work; acute liver disease; cell type; college; gene therapy; human disease; imaging modality; in vivo; liver function; radiotracer; stem cell biology; therapy development

Animal models of human disease constitute an indispensable modality for Center Investigators. Studies of liver cell transplantation, gene therapy and hepatic pathophysiology remain a major focus of the Center. The Special Animal Core continues to thrive under Dr. Gupta's expert direction, now well into its second decade. During previous funding periods, the Core provided services to Center Investigators, as well as to investigators outside of the Liver Center and the College of Medicine. Animals are provided by the Core to facilitate studies concerning development of therapies for metabolic deficiency states, genetic liver disease, and acute or chronic liver failure. In addition, animals provided by the Core facilitate studies of hepatic gene expression, progenitor cell and stem cell biology, and liver growth control. With many studies performed in vivo, use of well-characterized animal models with unique genetic characteristics has been invaluable and will remain so in the future.

人类疾病的动物模型构成了中心研究人员必不可少的方式。 肝细胞移植，基因治疗和肝病生理学的研究仍然是主要重点 中心。特殊的动物核心继续在古普塔博士的专家指导下蓬勃发展 到第二个十年。在以前的资金期间，核心为中心提供服务 研究人员以及肝脏中心和医学院外的调查人员。 核心提供动物，以促进有关开发疗法的研究 代谢缺陷状态，遗传肝病以及急性或慢性肝衰竭。此外， 核心提供的动物促进肝基因表达，祖细胞​​和茎的研究 细胞生物学和肝脏生长控制。随着许多研究在体内进行，使用良好 具有独特遗传特征的动物模型是无价的，并且将保留在 未来。