Animal Models, Stem Cells and Cell Therapy

动物模型、干细胞和细胞疗法

• 批准号: 9133724
• 负责人: SANJEEV GUPTA
• 金额: $ 23.64万
• 依托单位: ALBERT EINSTEIN COLLEGE OF MEDICINE, INC
• 依托单位国家: 美国
• 财政年份: 2015
• 资助国家: 美国
• 起止时间: 2015-09-01 至 2019-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9133724
• 关键词: Acute; Animal Model; Animals; Attention; Autophagocytosis; Breeding; Cell Culture Techniques; Cell Therapy; Cellular biology; Chronic; Consultations; Cost Savings; Development; Disease; Disease model; Educational Activities; Experimental Designs; Gene Expression; Generations; Growth; Hepatic; Hepatocyte; Hepatolenticular Degeneration; Hereditary Disease; Human; Inflammation; Liver; Liver Failure; Liver diseases; Metabolic; Metabolic Diseases; Methods; Pluripotent Stem Cells; Positioning Attribute; Procedures; Protocols documentation; Radiation Injuries; Rare Diseases; Research; Research Personnel; Resources; Services; Source; Staging; Technology; Therapeutic Studies; Translational Research; Viral hepatitis; cell preparation; cell type; cost effective; gene therapy; human stem cells; insight; new technology; novel; novel diagnostics; novel therapeutics; response; stem; stem cells; therapeutic development; tool

The Animal Models, Stem Cells and Cell Therapy Core facilitates translational research in the Marion Bessin Liver Research Center by providing unique resources, technologies and scientific expertise at cost savings. The Core was reorganized since previous the Center renewal, preserving all previous services and including additional services in response to the evolving needs of Center Investigators. The Core has accumulated extensive expertise in cutting-edge technologies and resources for studies using various liver cell types, including stem cells, as well as unique animal models. This benefits Center Investigators pursuing basic studies of pathophysiological mechanisms or cell and gene therapy. For instance, exciting opportunities are generated for Center Investigators through expertise in disease models, distribution of high quality cell preparations, which were instrumental for novel therapeutic developments in metabolic deficiency states, genetic diseases, radiation injury and acute or chronic liver failure. Simultaneously, numerous studies were advanced in hepatic gene expression, stem/progenitor cell biology, inflammation, autophagy, liver growth control, pathophysiological mechanisms of liver transport. Similarly, educational activities position the Core as an important resource. The Aims of this Core are as follows: To breed, maintain and provide animals that are not readily available from other sources, " To develop or reproduce relevant induced animal models. To isolate and distribute high quality primary animal or human liver cells, " To provide liver cells generated from pluripotent stem cells using highly efficient protocols, " To instruct investigators in stem cell methods and commonly used animal procedures, " To offer consultation for experimental design for animal studies To provide optimized, cost-effective liver cell culture conditions and additives, " To incorporate new technologies for animal and human stem cell and cell therapy studies, " To encourage use of the Core by early-stage investigators or investigators new to liver research.

动物模型，干细胞和细胞疗法核心核心通过提供独特的资源，技术和科学专业知识来节省成本，从而促进了Marion Bessin肝脏研究中心的转化研究。自之前的中心续签以来，核心进行了重组，保留了所有以前的服务，并为中心调查人员的不断发展需求提供了其他服务。核心在使用各种肝细胞类型（包括干细胞）以及独特的动物模型的研究方面积累了广泛的专业知识。该中心的研究人员正在研究病理生理机制或细胞和基因治疗的基础研究。例如，通过疾病模型的专业知识，高质量细胞制剂的分布，为中心研究人员带来了激动人心的机会，这对代谢缺陷状态，遗传疾病，放射线损伤以及急性或慢性肝衰竭的新型治疗发展起着重要作用。同时，在肝基因表达，茎/祖细胞生物学，炎症，自噬，肝脏生长控制，肝脏转运的病理生理机制方面进行了许多研究。同样，教育活动将核心定位 作为重要资源。该核心的目的如下： 繁殖，维护和提供其他来源不容易获得的动物， “开发或复制相关的诱导动物模型。 为了隔离和分布高质量的原代动物或人肝细胞， “提供使用高效方案从多能干细胞产生的肝细胞， “要指导研究人员进行干细胞方法和常用动物程序， “为动物研究提供实验设计咨询 为了提供优化的，具有成本效益的肝细胞培养条件和添加剂， “为了纳入动物和人类干细胞和细胞疗法研究的新技术， “鼓励新的肝脏研究的早期研究人员或研究人员使用核心。