Thalamocortical cognitive networks in the healthy human brain

健康人脑中的丘脑皮质认知网络

• 批准号: 10633809
• 负责人: Anne G.E. Collins
• 金额: $ 36.2万
• 依托单位: PRINCETON UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2023
• 资助国家: 美国
• 起止时间: 2023-04-03 至 2028-03-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10633809
• 关键词: Adult; Animal Model; Animals; Architecture; Attention; Behavior; Behavioral; Brain; Characteristics; Chemicals; Cognition; Cognitive; Complement; Complex; Computer Models; Data; Decision Making; Development; Environment; Fingerprint; Foundations; Functional Magnetic Resonance Imaging; Functional disorder; Goals; Human; Individual; Knowledge; Link; Macaca; Maintenance; Medial; Medial Dorsal Nucleus; Methods; Modeling; Molecular; Neurons; Parietal; Parietal Lobe; Play; Prefrontal Cortex; Primates; Property; Pulvinar structure; Role; Schizophrenia; Source; Standardization; Structure; Testing; Thalamic Nuclei; Thalamic structure; Theoretical model; Tupaiidae; Uncertainty; Variant; Visual; analysis pipeline; cognitive control; cognitive function; flexibility; insight; neural; neuroimaging; operation; recruit; response; support network

Abstract This project will characterize the functions of the human pulvinar (PUL) and mediodorsal (MD) nuclei and their role in brain-wide networks promoting a variety of high-level cognitive functions and behaviors. We propose to perform whole-brain fMRI to test the Center hypothesis that PUL and MD play crucial roles in coordinating information within and across cortical networks. Working closely with P5 (Woodward) and Core C (Chen), Aim 1 will resolve the internal organization of PUL and MD in healthy individuals based on functional connectivity with cortical networks involved in high-level cognitive functions. We will compare network topologies to those found in schizophrenia (P5) to identify dysfunction of cortical and thalamic nodes and in their interconnectivity. In Aim 2, we will adapt the Center’s APU and HDM tasks to assess the PUL and MD’s roles as centralized hubs for integrating information across cognitive control networks. The use of common tasks with tree shrews and macaques (P1-3) will allow for bridging across animal models spanning scales of representation from neurons to circuits to networks. In Aim 3, we will use a variant of the HDM task to identify human-unique characteristics of thalamocortical cognitive control networks that support flexible rule switching and generalization. We will use computational cognitive modeling to bridge between neuroimaging and behavior. Resolving the network-level architecture of PUL-cortical and MD-cortical function during complex cognitive behaviors will provide empirical and computational insights into the principles guiding behaviorally-relevant thalamocortical function (Center Aim 1), which will serve as a basis for assessing dysfunction (Center Aim 2) and inform the development of a mechanistic model for human thalamic function (Center Aim 3).

抽象的 该项目将表征人类Pulvinar（pul）和媒介道（MD）核的功能及其 在促进各种高级认知功能和行为的大脑网络中的作用。我们建议 执行全脑功能磁共振成像，以测试中心假设，即PUL和MD在协调中起着至关重要的作用 在皮质网络内部和跨层网络中的信息。与P5（Woodward）和Core C（Chen）紧密合作，AIM 1将根据功能连通性解决健康个体中PUL和MD的内部组织 具有高级认知功能的皮质网络。我们将将网络拓扑与那些进行比较 在精神分裂症（P5）中发现，以鉴定皮质和丘脑淋巴结的功能障碍以及它们的相互连接性。 在AIM 2中，我们将调整中心的APU和HDM任务，以评估PUL和MD作为集中式枢纽的角色 用于整合跨认知控制网络的信息。用树r和 猕猴（P1-3）将允许跨动物模型桥接跨越神经元的表示的尺度 到网络圆圈。在AIM 3中，我们将使用HDM任务的变体来识别人类唯一特征 丘脑皮质认知控制网络的支持，这些网络支持灵活规则切换和概括。我们将使用 计算认知建模，以在神经影像和行为之间桥接。解决网络级别 复杂的认知行为期间脉冲皮层和MD皮层功能的结构将提供经验 以及对指导与行为相关的丘脑皮质功能的原理的计算见解（中心目标） 1），这将作为评估功能障碍（中心目标2）的基础，并告知开发 人丘脑功能的机械模型（中心目标3）。