RESPIRATORY DISTRESS IN NEWBORNS/GBS COLONIZATION

新生儿呼吸困难/GBS 定植

• 批准号: 7789105
• 负责人: LEONARD E. WEISMAN
• 金额: $ 10.03万
• 依托单位: BAYLOR COLLEGE OF MEDICINE
• 依托单位国家: 美国
• 财政年份: 2007
• 资助国家: 美国
• 起止时间: 2007-09-28 至 2009-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7789105
• 关键词: RESPIRATORY; DISTRESS; NEWBORNS; GBS; COLONIZATION

The preliminary finding of an association of group B streptococcus (GBS) colonization, beta-lactam use during labor and respiratory distress in newborns will be validated in a prospective adequately powered study. The goals of the study are 1) to relate levels of serum bacterial phospholipids to the occurrence of respiratory distress in newborns of mothers colonized by GBS; and 2) to evaluate the effects of beta-lactam use during labor on the release of bacterial phospholipids and thus, the occurrence of respiratory distress in newborns of mothers colonized with GBS. This study will also examine the pathologic effects of ¿asymptomatic¿ GBS colonization and potential adverse effects of beta-lactam use during labor on the newborns. In addition, other potential adverse events or morbidities in mothers and newborns associated with the use of intrapartum antibiotics will be evaluated.

B 族链球菌 (GBS) 定植、分娩期间使用 β-内酰胺和新生儿呼吸窘迫之间的关联的初步发现将在一项充分有力的前瞻性研究中得到验证。该研究的目标是 1) 关联血清细菌水平。磷脂对 GBS 定植母亲新生儿呼吸窘迫发生的影响；2) 评估分娩期间使用 β-内酰胺对细菌磷脂释放的影响，从而评估新生儿呼吸窘迫发生的影响；这项研究还将检查 ¿ 的病理影响。无症状?? GBS 定植以及分娩过程中使用 β-内酰胺对新生儿的潜在不良影响 此外，还将评估与使用产时抗生素相关的母亲和新生儿的其他潜在不良事件或发病率。