RESPIRATORY DISTRESS IN NEWBORNS/GBS COLONIZATION

新生儿呼吸困难/GBS 定植

• 批准号: 7579512
• 金额: $ 54.94万
• 依托单位国家: 美国
• 财政年份: 2007
• 资助国家: 美国
• 起止时间: 2007-09-28 至 2009-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7579512
• 关键词: RESPIRATORY; DISTRESS; NEWBORNS; GBS; COLONIZATION

The preliminary finding of an association of group B streptococcus (GBS) colonization, beta-lactam use during labor and respiratory distress in newborns will be validated in a prospective adequately powered study. The goals of the study are 1) to relate levels of serum bacterial phospholipids to the occurrence of respiratory distress in newborns of mothers colonized by GBS; and 2) to evaluate the effects of beta-lactam use during labor on the release of bacterial phospholipids and thus, the occurrence of respiratory distress in newborns of mothers colonized with GBS. This study will also examine the pathologic effects of ¿asymptomatic¿ GBS colonization and potential adverse effects of beta-lactam use during labor on the newborns. In addition, other potential adverse events or morbidities in mothers and newborns associated with the use of intrapartum antibiotics will be evaluated.

B组链球菌（GBS）定殖，在劳动期间使用β-内酰胺和新生儿呼吸窘迫的初步发现将在一项前瞻性适当的动力研究中得到验证。研究的目标是1）将血清细菌磷脂的水平与GBS定居的母亲的新生儿的呼吸窘迫相关联； 2）评估β-内酰胺在分娩过程中使用对细菌磷脂释放的影响，这项研究还将检查–无症状的GBS殖民化和β-乳糖在劳动期间对新生儿的潜在不利影响的病理影响。此外，还将评估母亲和新生儿的其他潜在不良事件或与使用抗生素有关的新生儿。