PREDICT NEED FOR RESPIRATORY SUPPORT AND SURFACTANT IN NEWBORNS

预测新生儿对呼吸支持和表面活性剂的需求

• 批准号: 7717904
• 负责人: WILLIAM RHINE
• 金额: $ 0.15万
• 依托单位: STANFORD UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2007
• 资助国家: 美国
• 起止时间: 2007-12-01 至 2008-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7717904
• 关键词: Birth; Birth Place; Birth Weight; Caring; Chronic lung disease; Clinical; Computer Retrieval of Information on Scientific Projects Database; Consensus; Continuous Positive Airway Pressure; Devices; Enrollment; Exhalation; Funding; Grant; Guidelines; Infant; Institution; Judgment; Lead; Measurement; Mechanical Ventilators; Mechanical ventilation; Newborn Infant; Observational Study; Outcome; Patients; Physiological; Premature Infant; Research; Research Personnel; Resources; Respiratory distress; Source; Steroids; Suggestion; Trauma; United States National Institutes of Health; improved; nCPAP Ventilation; prospective; pulmonary function; respiratory; surfactant

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Increased use of antenatal steroids, surfactant, along with mechanical ventilation, has improved outcomes for premature infants. However, the possible overuse of mechanical ventilators may lead to trauma and chronic lung disease. There is some suggestion that some premature infants may have better outcomes if not intubated at birth, but placed on nasal continuous positive airway pressure (CPAP). At present, there are no consensus guidelines on which infants should be placed on CPAP at birth or intubated. A physiologic measurement, such as spontaneous exhaled volume, may be able to provide guidance in treatment course for newborns with respiratory distress. The aim of this study is to determine if a commercial portable pulmonary function measurement device can be used to predict the need for respiratory support and surfactant soon after birth. This will be a prospective, observational study. The measurements will not be revealed to the clinical team, who will use their judgment in deciding the patient's course of care. Outcomes will include degree of respiratory support and surfactant therapy. We plan to enroll approximately 100 patients, 50 below 1500 grams birth weight.

该子项目是利用该技术的众多研究子项目之一 资源由 NIH/NCRR 资助的中心拨款提供。子项目及 研究者 (PI) 可能已从 NIH 的另一个来源获得主要资金， 因此可以在其他 CRISP 条目中表示。列出的机构是 对于中心来说，它不一定是研究者的机构。 增加产前类固醇、表面活性剂的使用以及机械通气可以改善早产儿的结局。然而，过度使用机械呼吸机可能会导致创伤和慢性肺部疾病。有人建议，一些早产儿如果在出生时不插管，而是接受经鼻持续气道正压通气 (CPAP) 治疗，可能会有更好的结局。目前，对于哪些婴儿在出生时应接受 CPAP 治疗或插管尚无共识指南。生理测量，例如自发呼气量，可能能够为患有呼吸窘迫的新生儿的治疗过程提供指导。本研究的目的是确定是否可以使用商用便携式肺功能测量设备来预测出生后不久对呼吸支持和表面活性剂的需求。这将是一项前瞻性、观察性研究。这些测量结果不会透露给临床团队，临床团队将根据自己的判断来决定患者的治疗方案。结果将包括呼吸支持程度和表面活性剂治疗。我们计划招募大约 100 名患者，其中 50 名出生体重低于 1500 克。