Novel Antibacterial Fluoride-releasing Dental Materials

新型抗菌释氟牙科材料

• 批准号: 7778363
• 负责人: XIAOMING XU
• 金额: $ 35.15万
• 依托单位: LSU HEALTH SCIENCES CENTER
• 依托单位国家: 美国
• 财政年份: 2009
• 资助国家: 美国
• 起止时间: 2009-03-01 至 2013-01-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7778363
• 关键词: Accounting; Adhesives; Adopted; Animals; Anti-Bacterial Agents; Area; Bacteria; Caries prevention; Child; Clinical Trials; Complex; Compomers; Composite Dental Resin; Dental; Dental Bonding; Dental Enamel; Dental Materials; Dental caries; Dentists; Development; Diabetes Mellitus; Drug Formulations; Economics; Elderly; Extravasation; Filler; Fluorides; Fright; Future; Generations; Glass; Goals; Growth; Head and neck structure; Healthcare; Human; In Vitro; Investigation; Lactic acid; Lactobacillus casei; Lead; Lesion; Longevity; Lysine; Mechanics; Microbial Biofilms; Modeling; Oral health; Patients; Pharmaceutical Preparations; Physically Challenged; Plant Resins; Population; Property; Quality of life; Recurrence; Risk; Series; Sjogren' s Syndrome; Streptococcus mutans; Structure; Sucrose; Syndrome; System; Testing; Tooth structure; Vulnerable Populations; Xerostomia; Zirconium; ammonium fluoride; antimicrobial; base; biomaterial compatibility; calcium phosphate; diabetic; high risk; improved; irradiation; microleakage; monomer; novel; pandemic disease; prevent; remineralization; restoration; restorative material; scale up; seal; socioeconomics; zirconium oxide

DESCRIPTION (provided by applicant): We propose to investigate and develop novel dental materials that are antibacterial and/or fluoride-releasing and act synergistically to form a highly effective caries-inhibition restorative system. Such materials are expected to have an enormous impact on the oral health of the most vulnerable, high caries-risk, portion of the population: the medically-compromised who suffer from xerostomia or dry mouth (due to Sjvgren's syndrome, diabetes, head and neck irradiation, and medications), children, the elderly, and low socio-economic groups. Dental caries continues to be a worldwide pandemic disease. While resin-based dental composites (RBC) are widely used to restore carious teeth, secondary (recurrent) caries remains the leading cause cited for their replacement. Thus, much effort has been directed towards development of composites that release caries-preventing agents such as fluoride. Nevertheless, current dental composites are deficient in both fluoride-release and fluoride-recharge capabilities, and very few have antimicrobial or other capabilities for preventing plaque. Furthermore, all dental composites and compomers require bonding agents in order to reduce marginal leakage and limit secondary caries. Yet, both non-fluoride-releasing and low-fluoride-releasing bonding agents are inherently barriers to the transport of fluoride to caries-prone areas. Another problem is that the majority of self-etching dental bonding agents are susceptible to hydrolytical degradation, which leads to eventual leakage, secondary caries and reduced RBC lifetime. On the primary caries prevention front, sealants, including fluoride-releasing sealants, have shown caries-prevention efficacy, yet the dental profession has been slow to adopt sealants due, in part, to the fear that caries will continue to progress under sealed pits and fissures. The goal of this project is to develop novel monomers with enhanced antibacterial activity, enhanced fluoride release and recharge, and other capabilities, and combine them with fluoride-releasing fillers and bioactive fillers to overcome the multiple problems associated with current composites, adhesives and sealants that limit their caries-inhibition efficacy and restoration longevity. This project has four specific aims: (1) to formulate and optimize a novel antibacterial fluoride releasing dental composite, (2) to formulate and optimize a novel hydrolytically stable fluoride-releasing dental bonding agent, (3) to formulate and characterize a novel antibacterial bioactive sealant that releases calcium, phosphate, and fluoride, (4) to test the overall caries-inhibition efficacy of the novel anticariogenic dental material system by artificial caries models. The hypotheses are: (1) Dental materials containing the new fluoride exchange monomers will have enhanced fluoride release and recharge capabilities while maintaining adequate or improved physical and mechanical properties. (2) The combination of antimicrobial activity with enhanced remineralization capability will synergistically lead to significantly higher caries-inhibiting efficacy of the restorative materials. (3) The combined use of an antibacterial fluoride-releasing composite, bonding agent and bioactive sealant will further reduce caries. This project seeks to develop a series of antibacterial, fluoride-releasing, and bioactive dental materials. These materials are expected to have enhanced anti-caries efficacy over existing resin-based dental materials. The development of these materials has the potential to make a huge impact on oral health care and oral health quality-of-life, in particular for the vast number of high-caries-risk patients (medically compromised who suffer from xerostomia or dry mouth, children, elderly, mentally or physically challenged).

描述（由申请人提供）：我们建议研究和开发抗菌和/或氟化物释放的新型牙科材料，并协同作用以形成高效的龋齿抑制修复系统。预计此类材料将对最脆弱，最高龋齿风险，人口的口腔健康产生巨大影响：患有静脉或口干的医学表现症（由于Sjvgren综合征，糖尿病，头部和颈部和颈部辐射和药物），儿童，老年人，低社会经济学。龋齿仍然是一种全球大流行病。虽然基于树脂的牙科复合材料（RBC）被广泛用于恢复龋齿，但次要（经常性）龋齿仍然是引用其替代的主要原因。因此，已经为开发释放龋齿剂（如氟化物）的复合材料而进行了很多努力。然而，当前的牙齿复合材料在氟化物释放和氟化物 - 回声能力方面都缺乏，很少有抗菌或其他能力可防止斑块。此外，所有牙科复合材料和复合物都需要粘合剂，以减少边际泄漏并限制次要龋齿。然而，非氟化物释放和低氟化物释放的粘合剂均来本质上是氟化物运输到容易发生区域的障碍。另一个问题是，大多数自我蚀刻牙齿键合剂都容易受到水解降解的影响，这最终导致泄漏，次要龋齿和RBC寿命降低。在预防龋齿方面，密封胶（包括释放氟化物的密封剂）已经显示出预防症状的功效，但是牙科专业的采用速度很慢，部分原因是，由于担心龋齿会继续在密封坑和裂缝下继续前进。该项目的目的是开发具有增强抗菌活性，增强氟化物释放和充电以及其他功能的新型单体，并将它们与氟化物释放的填充剂和生物活性填充剂相结合，以克服与当前复合材料，粘合剂和密封剂相关的多个问题，这些问题限制了其在Cari​​es抑制其良好的效率和恢复效果。该项目具有四个特定的目的：（1）制定和优化一种新型的抗菌氟化物释放牙齿复合材料，（2）以制定和优化一种新型的水解含氧氧耐碳粘结剂的牙科粘合剂（3），以制定和表征新型的抗体生物活性密封剂，以验证抗生素的cariention carimim carifientim carifition carifation carifient（4），磷酸化（磷酸化），磷酸化，磷酸化，磷酸化，磷酸化，磷酸化，磷酸化，磷酸化效果（磷酸化，磷酸化，磷酸化剂，磷酸盐，磷酸化的效果，磷酸化剂，磷酸化剂，磷酸化剂，磷酸化剂，磷酸化剂磷酸盐磷酸化。通过人造龋齿模型的新型抗虫生成牙科材料系统。假设是：（1）含有新的氟化物交换单体的牙科材料将增强氟化物释放和充电能力，同时保持足够或改善的物理和机械性能。 （2）抗菌活性与增强的回忆能力的结合将在恢复性材料的疗效上显着抑制龋齿。 （3）抗菌氟化物释放复合材料，粘合剂和生物活性密封剂的联合使用将进一步减少龋齿。该项目旨在开发一系列抗菌，氟化物释放和生物活性牙科材料。预计这些材料将对现有的基于树脂的牙科材料提高抗奶酪功效。这些材料的开发有可能对口腔保健和口腔健康质量造成巨大影响，尤其是对大量高火风险危患者（患有心血管症或干嘴，儿童，老年人，精神上或身体上挑战的医学上受到损害的医学损害）。