Novel Antibacterial Fluoride-releasing Dental Materials

新型抗菌释氟牙科材料

基本信息

批准号：
8197641
负责人：
XIAOMING XU
金额：
$ 34.79万
依托单位：
LSU HEALTH SCIENCES CENTER
依托单位国家：
美国
项目类别：
财政年份：
2009
资助国家：
美国
起止时间：
2009-03-01 至 2014-01-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/8197641
关键词：
Accounting Adhesives Adopted Animals Anti-Bacterial Agents Area Bacteria Caries prevention Child Clinical Trials Complex Compomers Dental Dental Bonding Dental Enamel Dental Materials Dental caries Dentists Development Diabetes Mellitus Drug Formulations Economics Elderly Extravasation Filler Fluorides Fright Future Generations Glass Goals Growth Head and neck structure Healthcare Human In Vitro Investigation Lactic acid Lactobacillus casei Lead Lesion Longevity Lysine Mechanics Microbial Biofilms Modeling Oral health Patients Pharmaceutical Preparations Physically Challenged Plant Resins Population Property Quality of life Recurrence Risk Series Sjogren&apos s Syndrome Streptococcus mutans Structure Sucrose System Testing Tooth structure Vulnerable Populations Xerostomia Zirconium abstracting ammonium fluoride antimicrobial base biomaterial compatibility calcium phosphate diabetic high risk improved irradiation microleakage monomer novel pandemic disease prevent remineralization restoration restorative material scale up seal socioeconomics zirconium oxide

项目摘要

Project Description/Abstract We propose to investigate and develop novel dental materials that are antibacterial and/or fluoride- releasing and act synergistically to form a highly effective caries-inhibition restorative system. Such materials are expected to have an enormous impact on the oral health of the most vulnerable, high caries-risk, portion of the population: the medically-compromised who suffer from xerostomia or dry mouth (due to Sj¿gren's syndrome, diabetes, head and neck irradiation, and medications), children, the elderly, and low socio-economic groups. Dental caries continues to be a worldwide pandemic disease. While resin-based dental composites (RBC) are widely used to restore carious teeth, secondary (recurrent) caries remains the leading cause cited for their replacement. Thus, much effort has been directed towards development of composites that release caries-preventing agents such as fluoride. Nevertheless, current dental composites are deficient in both fluoride-release and fluoride- recharge capabilities, and very few have antimicrobial or other capabilities for preventing plaque. Furthermore, all dental composites and compomers require bonding agents in order to reduce marginal leakage and limit secondary caries. Yet, both non-fluoride-releasing and low-fluoride-releasing bonding agents are inherently barriers to the transport of fluoride to caries-prone areas. Another problem is that the majority of self-etching dental bonding agents are susceptible to hydrolytical degradation, which leads to eventual leakage, secondary caries and reduced RBC lifetime. On the primary caries prevention front, sealants, including fluoride-releasing sealants, have shown caries-prevention efficacy, yet the dental profession has been slow to adopt sealants due, in part, to the fear that caries will continue to progress under sealed pits and fissures. The goal of this project is to develop novel monomers with enhanced antibacterial activity, enhanced fluoride release and recharge, and other capabilities, and combine them with fluoride-releasing fillers and bioactive fillers to overcome the multiple problems associated with current composites, adhesives and sealants that limit their caries-inhibition efficacy and restoration longevity. This project has four specific aims: (1) to formulate and optimize a novel antibacterial fluoride releasing dental composite, (2) to formulate and optimize a novel hydrolytically stable fluoride-releasing dental bonding agent, (3) to formulate and characterize a novel antibacterial bioactive sealant that releases calcium, phosphate, and fluoride, (4) to test the overall caries-inhibition efficacy of the novel anticariogenic dental material system by artificial caries models. The hypotheses are: (1) Dental materials containing the new fluoride exchange monomers will have enhanced fluoride release and recharge capabilities while maintaining adequate or improved physical and mechanical properties. (2) The combination of antimicrobial activity with enhanced remineralization capability will synergistically lead to significantly higher caries-inhibiting efficacy of the restorative materials. (3) The combined use of an antibacterial fluoride-releasing composite, bonding agent and bioactive sealant will further reduce caries.

项目描述/摘要我们建议研究和开发抗菌和/或氟化物的新型牙科材料释放并协同行动以形成高效的龋齿抑制修复系统。预计此类材料将对最大的口腔健康产生巨大影响脆弱的，高性风险的人口中的一部分：受到医学上的强大症，遭受的痛苦静脉或口干（由于SJ®Gren的综合征，糖尿病，头颈部和颈部辐照，以及药物），儿童，老年人和低社会经济群体。牙科车仍然是全球大流行病。而基于树脂的牙科复合材料（RBC）被广泛用于还原心牙，次要（经常性）汽车仍然是替换的主要原因。那，已经大力致力于开发释放汽车预防代理商的公司例如氟化物。然而，当前的牙科复合材料在氟化物释放和氟化物中都缺乏充电能力，很少有抗菌或其他防止牙菌斑的能力。此外，所有牙科组成和兼容者都需要粘结剂才能减少边际泄漏并限制二级汽车。然而，非氟化物释放和低氟化物释放键代理本质上是氟化物运输到容易产生区域的障碍。另一个问题是大多数自我蚀刻牙齿键合剂都容易受到水解降解的影响，这导致最终泄漏，次要汽车和RBC寿命减少。在预防主要汽车方面，密封剂，包括释放氟化物的密封剂，已显示出预防效率，但牙科专业的采用密封剂的速度很慢，部分原因是担心汽车会继续前进密封的凹坑和裂缝。该项目的目的是开发具有增强抗菌活性的新型单体，增强氟化物释放和充电以及其他功能，并将其与氟化物释放的填充剂和生物活性填充剂以克服与当前复合材料，粘合剂和限制其抑制汽车效率和恢复寿命的密封剂。这个项目有四个特定的目的：（1）制定和优化一种新型的抗菌氟化物释放牙科复合材料，（2）以制定和优化一种新型的水解稳定氟化物释放牙齿粘合剂，（3）以制定和表征释放钙，磷酸盐和氟化物的新型抗菌生物活性密封剂，（4）测试总体通过人造性龋模型，新型抗虫生成牙科材料系统的龋齿抑制效率。假设是：（1）包含新的氟化物交换单体的牙科材料将增强氟化物释放和充电功能，同时保持足够或改善的物理和机械功能特性。（2）抗菌活性与增强的提高能力的结合将协同导致抑制恢复材料的效率明显更高的汽车。（3）抗菌氟化物释放复合材料，粘合剂和生物活性密封剂的联合使用将进一步减少龋齿。

项目成果

期刊论文数量（4）

专著数量（0）

科研奖励数量（0）

会议论文数量（0）

专利数量（0）

Formulation and characterization of antibacterial fluoride-releasing sealants.

抗菌释氟密封剂的配方和表征。

DOI：
发表时间：
2013
期刊：
Pediatric dentistry
影响因子：
1.6
作者：
Fan,Yuwei;Townsend,Janice;Wang,Yapin;Lee,EunChee;Evans,Katie;Hender,Erica;Hagan,JosephL;Xu,Xiaoming
通讯作者：
Xu,Xiaoming

Synthesis and Characterization of New Antibacterial Fluoride-Releasing Monomer and Dental Composite.