Novel F-releasing Nanocomposite Reinforced by Zirconia Nanofibers

氧化锆纳米纤维增强的新型释氟纳米复合材料

基本信息

批准号：
7277582
负责人：
XIAOMING XU
金额：
$ 24.43万
依托单位：
LSU HEALTH SCIENCES CENTER
依托单位国家：
美国
项目类别：
财政年份：
2007
资助国家：
美国
起止时间：
2007-04-01 至 2010-03-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/7277582
关键词：
Age Aging Ammonia Area Caliber Ceramics Clinic Colloids Color Condition Coupling Data Dental Dental Materials Dental caries Dentistry Development Devices End Point Esthetics Failure Feasibility Studies Fiber Filler Fluorides Fracture Future Gel Glass Ionomer Cements Goals Hydrolysis In Vitro Ions Life Mechanics Metals Morphology Nitrates Object Attachment Odontogenesis Particulate Plant Resins Process Property Recurrence Research Resistance Series Silanes Silicon Dioxide Solutions Structure Surface Technology Testing Tooth structure Vibrissae Water Yttrium Zirconium anticaries aqueous base catalyst chemical stability composite restoration concept fiberglass glass ionomer improved indexing inorganic phosphate interfacial monomer nanocomposite nanofiber nitrate novel pandemic disease physical property restoration restorative material silane silicon nitride tetraethoxysilane yttria zircon zirconium oxide

项目摘要

DESCRIPTION (provided by applicant): Resin-based dental composites have been widely used in dentistry to restore carious teeth. But composites may have shorter life than amalgams. The two leading causes for the failure of dental composite restorations in clinic are secondary (recurrent) caries and bulk fracture. To reduce secondary caries, research efforts have been directed towards the development of the dental composites that release anti-caries agents (F-, Ca2+ and PO4 3- ions).Current fluoride-releasing dental composites have very low fluoride-releasing and recharge capability. Glass ionomers and resin-modified glass ionomers (RMGI) have high fluoride release but they have low strength and fracture toughness. Despite significant development in this area in past 20 years, dental composites reinforced with particulate fillers, particularly those releasing anti-caries agents, still have inadequate strength and fracture toughness. To overcome the fracture problem, glass fibers and ceramic (SiC and Si3N4) whiskers have been used to improve the strength and fracture toughness of composites, but the chemical stability, esthetics and handling properties of these materials are unsatisfactory. The goal of this in vitro exploratory project is to study the feasibility of using zirconia-based ceramic nanofibers to reinforce fluoride-releasing dental composites. The hypotheses are: (1) zirconia-based ceramic nanofibers (100-300 nm) will significantly increase the mechanical properties and fracture toughness of the composite and provide better aesthetics and handling properties than the coarse fibers; (2) the composite reinforced by zirconia-based ceramic nanofibers will have significantly better chemical stability than glass fibers or Si3N4 whisker-reinforced composites. The aims of this project includes: (1) fabricating nanofibers of zirconia-based ceramics using sol-gel and reactive electrospinning process; (2) improving nanofiber dispersion and nanofiber-resin matrix interfacial properties by treatment with special surface coupling agents; (3) fabricating the zirconia nanofiber-reinforced, fluoride-releasing composites dental composites and testing their flexure strength, fracture toughness, wear resistance, color and gloss indices, and chemical stability after ageing in water. We anticipate that the novel fluoride-releasing composite reinforced by zirconia nanofibers will have significantly improved mechanical properties as well as high fluoride-releasing and recharging capabilities. The long-term goal of this project is to develop a series of nanofiber-reinforced dental restorative materials that have anti-caries efficacy, good aesthetics and handling properties as well as good mechanical properties. These improved dental materials will reduce secondary caries and prolong the life of restorations.

描述（由申请人提供）：树脂基牙科复合材料已广泛应用于牙科领域以修复龋齿。但复合材料的寿命可能比汞合金短。临床上复合牙修复失败的两个主要原因是继发性（复发性）龋齿和整体骨折。为了减少继发龋齿，研究工作集中在开发可释放防龋剂（F-、Ca2+和PO4 3- 离子）的牙科复合材料。目前的释氟牙科复合材料的氟释放和补给能力非常低。玻璃离聚物和树脂改性玻璃离聚物 (RMGI) 的氟化物释放量较高，但强度和断裂韧性较低。尽管过去 20 年该领域取得了重大发展，但用颗粒填料增强的牙科复合材料，特别是那些释放防龋剂的材料，仍然缺乏足够的强度和断裂韧性。为了克服断裂问题，玻璃纤维和陶瓷（SiC和Si3N4）晶须已被用来提高复合材料的强度和断裂韧性，但这些材料的化学稳定性、美观性和操作性能并不令人满意。该体外探索项目的目标是研究使用氧化锆基陶瓷纳米纤维增强释放氟化物的牙科复合材料的可行性。假设是：（1）氧化锆基陶瓷纳米纤维（100-300 nm）将显着提高复合材料的机械性能和断裂韧性，并提供比粗纤维更好的美观和操作性能； (2)氧化锆基陶瓷纳米纤维增强的复合材料将比玻璃纤维或Si3N4晶须增强的复合材料具有明显更好的化学稳定性。该项目的目标包括：（1）利用溶胶-凝胶和反应静电纺丝工艺制备氧化锆基陶瓷纳米纤维； (2)通过特殊的表面偶联剂处理，改善纳米纤维的分散性和纳米纤维-树脂基体的界面性能； (3)制备氧化锆纳米纤维增强释氟复合材料牙科复合材料并测试其弯曲强度、断裂韧性、耐磨性、颜色和光泽指数以及水中老化后的化学稳定性。我们预计，由氧化锆纳米纤维增强的新型释氟复合材料将具有显着改善的机械性能以及高释氟和再充电能力。该项目的长期目标是开发一系列具有防龋功效、良好的美观性和操作性以及良好的机械性能的纳米纤维增强牙科修复材料。这些改进的牙科材料将减少继发龋并延长修复体的寿命。