Effect of Contralateral Leg on Motor Output Post Stroke

对侧腿对电机输出后行程的影响

基本信息

批准号：
7792252
负责人：
Susanne M Morton
金额：
$ 11.44万
依托单位：
UNIVERSITY OF IOWA
依托单位国家：
美国
项目类别：
财政年份：
2006
资助国家：
美国
起止时间：
2006-04-01 至 2011-03-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/7792252
关键词：
3-Dimensional Affect Age Ankle Area Behavior Behavioral Bilateral Brain Contralateral Coupling Development Electromyography Exhibits Gait Gender Generations Goals Human Image Individual Ipsilateral Joints Lead Leg Lesion Limb structure Locomotion Locomotor Recovery Love Maintenance Measures Mechanics Medical Mentored Research Scientist Development Award Mentorship Modification Motor Motor Cortex Motor output Movement Muscle Nervous System Trauma Paresis Pathway interactions Pattern Performance Public Health Reaction Time Recovery Rehabilitation therapy Research Research Personnel Scientist Sensory Side Silver Spinal Stroke Structure Sum Techniques Training Transcranial magnetic stimulation Walking Wrist base career disability leave hemiparesis kinematics motor control neurophysiology neuroregulation novel post stroke response stroke rehabilitation tool

项目摘要

DESCRIPTION (provided by applicant): The purpose of this Mentored Research Scientist Development Award is to prepare the candidate for a successful long-term career in medical rehabilitative research. The candidate will receive primary sponsorship from a senior-level scientist who will provide the candidate with a period of intensive, focused training in the areas of motor cortical neurophysiology, motor cortical plasticity following stroke, and the use of transcranial magnetic stimulation as a research tool to measure cortical excitability. The purpose of the research proposed here is to determine mechanisms of bilateral leg control in individuals with post stroke hemi paresis; specifically, to determine the effects of the sensorimotor state of one leg on the motor behavior of the opposite leg. Three studies will be undertaken to determine: 1) does damage to the motor cortex cause specific deficits in bilateral more than unilateral cyclical ankle movements? 2) to what extent do ipsilateral uncrossed corticospinal pathways contribute to unilateral and bilateral cyclical ankle movements in individuals with motor cortical stroke? and 3) does damage to the motor cortex impair bilateral leg motor responses to a novel unilateral perturbation during walking? To answer these questions, 3-D movement kinematics and electromyography will be recorded from subjects with hemi paresis caused by motor cortical stroke and healthy age- and gender-matched control subjects performing ankle movement tasks and walking. Results will help explain the specific function of the motor cortex and corticospinal pathway and will provide a basis for the development of novel rehabilitation techniques to recover normal locomotor's function in individuals with post-stroke hemi paresis. The mentorship provided in this plan will help direct the candidate toward independence as an investigator and lend significant progress toward the candidate's long-term research goal of understanding interlimb coordination during human locomotion and mechanisms for recovery of locomotor's function following neurological damage. RELEVANCE: This research will have broad impact on public health, as stroke is a leading cause of long-term disability and leaves many of its victims unable to walk without assistance (AHA 2005). Findings from these studies are expected to help lead to the development of new treatments aimed at stroke rehabilitation generally and gait recovery specifically.

描述（由申请人提供）：这一指导研究科学家发展奖的目的是为候选人做好医学康复研究的长期职业的准备。候选人将从一位高级科学家那里获得主要赞助，他们将在运动皮质神经生理学，中风后的运动皮质可塑性以及使用经颅磁刺激作为研究工具的研究中，为候选人提供一段密集的，集中的培训。此处提出的研究的目的是确定中风后轻瘫患者双边腿控制的机制；具体而言，要确定一条腿的感觉运动状态对相对腿运动行为的影响。将进行三项研究以确定：1）对运动皮层的损害是否比单侧周期性踝部运动更多地导致双侧缺陷？ 2）在多大程度上，同侧无皮质脊髓途径有助于运动皮质中风的个体的单侧和双侧周期性踝运动？ 3）在步行过程中，对运动皮层的损害会损害双侧腿部运动反应吗？为了回答这些问题，将记录3-D运动运动学和肌电图，这些受试者是由运动皮质中风和健康的年龄和性别匹配的控制受试者引起的Hemi Paresis的受试者，执行踝关节运动任务和行走。结果将有助于解释运动皮质和皮质脊髓途径的特定功能，并将为开发新型康复技术的发展提供基础，以恢复中风后半瘫痪者的正常运动功能。本计划中提供的指导将有助于指导候选人成为研究者，并为候选人的长期研究目标提供了重大进展，即在人类运动过程中了解互联物的协调以及在神经系统损害后恢复运动功能的机制。相关性：这项研究将对公共卫生产生广泛的影响，因为中风是长期残疾的主要原因，并使许多受害者无法在没有帮助的情况下行走（AHA 2005）。这些研究的结果有望帮助开发针对中风康复的新疗法，并特别是步态恢复。