Effect of Contralateral Leg on Motor Output Post Stroke

对侧腿对电机输出后行程的影响

• 批准号: 7391649
• 负责人: Susanne M Morton
• 金额: $ 3.23万
• 依托单位: UNIVERSITY OF MARYLAND BALTIMORE
• 依托单位国家: 美国
• 财政年份: 2006
• 资助国家: 美国
• 起止时间: 2006-04-01 至 2008-08-14
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7391649
• 关键词: 3-Dimensional; Affect; Ankle; Area; Behavior; Behavioral; Bilateral; Brain; Contralateral; Coupling; Development; Disruption; Electromyography; Exhibits; Gait; Gender; Generations; Goals; Human; Image; Individual; Ipsilateral; Joints; Lead; Leg; Lesion; Limb structure; Locomotion; Locomotor Recovery; Love; Maintenance; Measures; Mechanics; Medical; Mentored Research Scientist Development Award; Mentorship; Modification; Motor; Motor Cortex; Motor output; Movement; Muscle; Nervous System Trauma; Pathway interactions; Pattern; Performance; Public Health; Purpose; Reaction Time; Recovery; Rehabilitation therapy; Research; Research Personnel; Scientist; Sensory; Side; Silver; Spinal; Stroke; Structure; Sum; Techniques; Thinking; Training; Transcranial magnetic stimulation; Walking; Wrist; base; career; disability leave; healthy aging; hemiparesis; kinematics; motor control; neurophysiology; neuroregulation; novel; post stroke; response; stroke rehabilitation; tool

PROJECT SUMMARY: The purpose of this Mentored Research Scientist Development Award is to prepare the candidate for a successful long-term career in medical rehabilitative research. The candidate will receive primary sponsorship from a senior-level scientist who will provide the candidate with a period of intensive, focused training in the areas of motor cortical neurophysiology, motor cortical plasticity following stroke, and the use of transcranial magnetic stimulation as a research tool to measure cortical excitability. The purpose of the research proposed here is to determine mechanisms of bilateral leg control in individuals with post- stroke hemiparesis; specifically, to determine the effects of the sensorimotor state of one leg on the motor behavior of the opposite leg. Three studies will be undertaken to determine: 1) does damage to the motor cortex cause specific deficits in bilateral more than unilateral cyclical ankle movements? 2) to what extent do ipsilateral uncrossed corticospinal pathways contribute to unilateral and bilateral cyclical ankle movements in individuals with motor cortical stroke? and 3) does damage to the motor cortex impair bilateral leg motor responses to a novel unilateral perturbation during walking? To answer these questions, 3-D movement kinematics and electromyography will be recorded from subjects with hemiparesis caused by motor cortical stroke and healthy age- and gender-matched control subjects performing ankle movement tasks and walking. Results will help explain the specific function of the motor cortex and corticospinal pathway and will provide a basis for the development of novel rehabilitation techniques to recover normal locomotor function in individuals with post-stroke hemiparesis. The mentorship provided in this plan will help direct the candidate toward independence as an investigator and lend significant progress toward the candidate's long- term research goal of understanding interlimb coordination during human locomotion and mechanisms for recovery of locomotor function following neurological damage. RELEVANCE: This research will have broad impact on public health, as stroke is a leading cause of long- term disability and leaves many of its victims unable to walk without assistance (AHA 2005). Findings from these studies are expected to help lead to the development of new treatments aimed at stroke rehabilitation generally and gait recovery specifically.

项目摘要：这个受过指导的研究科学家发展奖的目的是准备 成功从事医学康复研究长期职业的候选人。候选人将收到 一位高级科学家的主要赞助 在运动皮质神经生理学，中风后运动皮质可塑性和 使用经颅磁刺激作为测量皮质兴奋性的研究工具。目的 此处提出的研究是确定在患有后的个体中双边腿控制机制 中风半瘫痪；具体而言，要确定一条腿的感觉运动状态对电动机的影响 相反的腿的行为。将进行三项研究以确定：1）对电动机造成损害 皮质在双侧导致比单侧周期性踝部运动多？ 2）在多大程度上做 同侧无皮质脊髓途径有助于单侧和双侧周期性踝运动 患有运动皮质中风的人？ 3）损坏运动皮层损害双侧腿部电动机 步行过程中对新型单方面扰动的反应？要回答这些问题，3-D移动 运动学和肌电图将记录在由运动皮质引起的偏瘫的受试者中记录 中风和健康的年龄和性别匹配的对照对象执行踝关节运动任务和 步行。结果将有助于解释运动皮质和皮质脊髓途径的特定功能，并将 为开发新型康复技术的发展提供了恢复正常运动功能的基础 中风后半瘫痪的人。本计划中提供的指导将有助于指导 候选人成为研究者，并为候选人的长期发展取得了重大进展 理解人类运动和机制中跨越协调的术语研究目标 神经系统损害后的运动功能的恢复。 相关性：这项研究将对公共卫生产生广泛的影响，因为中风是长期的主要原因 任期残疾，并使许多受害者无法在没有帮助的情况下行走（AHA 2005）。来自 预计这些研究将有助于发展旨在中风康复的新疗法 一般而言和步态恢复。