Resources and workforce development for the New England Regional Biosafety Laboratory

新英格兰地区生物安全实验室的资源和劳动力发展

• 批准号: 10793931
• 负责人: Cheryl A London
• 金额: $ 243.51万
• 依托单位: TUFTS UNIVERSITY BOSTON
• 依托单位国家: 美国
• 财政年份: 2023
• 资助国家: 美国
• 起止时间: 2023-08-18 至 2028-07-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10793931
• 关键词: Address; Animal Model; Animal Welfare; Bacteriology; Biological Models; Biology; Categories; Certification; Communicable Diseases; Communities; Community Health Education; Community Outreach; Competence; Complement; Containment; Decontamination; Disease; Eastern Equine Encephalomyelitis; Education; Elements; Emerging Communicable Diseases; Ensure; Environment; Environmental Health; Equipment; Future; Goals; Health; Human Resources; Individual; Industry; Infection; Infectious Diseases Research; Influenza; Infrastructure; Institution; Knowledge; Laboratories; Laboratory Animal Medicine; Laboratory Research; Maintenance; Methods; Microbiology; Mission; Mycobacterium tuberculosis; National Institute of Allergy and Infectious Disease; New England; Operations Research; Positioning Attribute; Postdoctoral Fellow; Powassan encephalitis; Preventive; Procedures; Protocols documentation; Qualifying; Research; Research Assistant; Research Personnel; Research Support; Resource Development; Resources; Risk; Safety; Schedule; Schools; Scientist; Services; Specialist; System; Technical Expertise; Training; Tularemia; United States National Institutes of Health; Universities; Work; Workforce Development; biocontainment facility; biosecurity; contextual factors; design; experience; industry partner; laboratory manuals; medical countermeasure; member; operation; pandemic disease; pandemic pathogen; pandemic potential; pandemic response; pathogen; professor; public health emergency; repaired; response; screening; skills; vector; virology

PROJECT SUMMARY - OVERALL The New England Regional Biosafety Laboratory (NERBL) was established in 2008 with the goal of ensuring that research and tasks in response to pathogens of pandemic potential and other emerging infections (PPP/EI) are safely, efficiently, and rigorously accomplished. The NERBL was also designed to serve as a regional resource for academic and industry partners engaged in activities that yield knowledge and medical countermeasures to PPP/EI and ready to serve as directed by NIH/NIAID/federal partners in whatever capacity necessary for pandemic response. A critical element necessary for effective functioning of any biosafety/biocontainment laboratory is the existence of core competencies associated with physical, operational, regulatory and research (vivarium/laboratory) tasks frequently performed in this setting. Individuals working in the context of biocontainment must possess advanced technical skills, have undergone extensive BSL-3/ABSL-3 training, and continuously enhance their knowledge regarding agent specific risk. Additionally, to maintain operational integrity of a biocontainment facility and adequately safeguard the staff, environment, and local community, functional redundancies in these skills and associated responsibilities are an absolute necessity. As such, the primary objective of this application is to expand and maintain a footprint of highly qualified staff within the NERBL that possess a set of core competencies for specific function categories (i.e., vivarium, facilities), while also cross-trained to undertake additional responsibilities should the need arise. Accordingly, we have proposed three Cores within the context of this application to achieve this overarching goal. Core 1 will oversee facility management, maintenance and operations, ensuring integrity and sustainability of the NERBL infrastructure. Core 2 will entail activities that cover BSL3/ABSL3 best practices, including laboratory specific biosafety, biosecurity education, vivarium specific trainings and research competencies. Lastly, Core 3 will serve as the biocontainment research support services core, expanding capacities for bacteriology, virology and vector biology. Core members will undergo rigorous cross-training to create the functional redundancies necessary for ensuring continuity of services. Together, these activities will allow us to fulfill our mission as a resource for Tufts University, academic partners, industry entities, state/federal investigators, as well as for our RBL/NBL Network members. Importantly, following completion of the stated milestones, the NERBL will be well-positioned and sufficiently resourced to rapidly respond to future emerging infectious disease threats.

项目概要 - 总体 新英格兰地区生物安全实验室 (NERBL) 成立于 2008 年，目标是确保 针对可能发生大流行的病原体和其他新出现的感染的研究和任务 （PPP/EI）安全、高效、严格地完成。 NERBL 还被设计为作为 为从事知识和医疗活动的学术和行业合作伙伴提供区域资源 针对 PPP/EI 的反制措施，并准备好按照 NIH/NIAID/联邦合作伙伴的指示以任何身份提供服务 应对疫情所必需的。任何机构有效运作所必需的关键要素 生物安全/生物防护实验室是与物理、 在此环境中经常执行操作、监管和研究（动物园/实验室）任务。 在生物防护背景下工作的个人必须具备先进的技术技能，并经历过 广泛的 BSL-3/ABSL-3 培训，并不断增强他们有关代理特定风险的知识。 此外，为了保持生物防护设施的运行完整性并充分保护工作人员， 环境和当地社区，这些技能和相关责任的职能冗余是 绝对有必要。因此，该应用程序的主要目标是扩展和维护 NERBL 内拥有一批高素质员工，他们拥有一系列核心能力 特定功能类别（即动物园、设施），同时还接受交叉培训以承担额外的任务 必要时应承担的责任。因此，我们在此背景下提出了三个核心 应用程序来实现这一总体目标。核心 1 将监督设施管理、维护和 运营，确保 NERBL 基础设施的完整性和可持续性。核心 2 将涉及以下活动： 涵盖 BSL3/ABSL3 最佳实践，包括实验室特定生物安全、生物安全教育、动物园 具体培训和研究能力。最后，Core 3 将作为生物防护研究 支持服务核心，扩大细菌学、病毒学和媒介生物学的能力。核心成员将 接受严格的交叉培训，以创建必要的职能冗余，以确保业务的连续性 服务。总之，这些活动将使我们能够履行作为塔夫茨大学资源的使命， 学术合作伙伴、行业实体、州/联邦调查人员以及我们的 RBL/NBL 网络 成员。重要的是，在完成规定的里程碑之后，NERBL 将处于有利位置并 拥有足够的资源来快速应对未来新出现的传染病威胁。