Administrative Core-Interdisciplinary Ctr for Male Contraceptive Res & Drug Dev

行政核心-男性避孕研究跨学科中心

• 批准号: 7789621
• 负责人: JOSEPH S TASH
• 金额: $ 10.89万
• 依托单位: UNIVERSITY OF KANSAS MEDICAL CENTER
• 依托单位国家: 美国
• 财政年份: 2009
• 资助国家: 美国
• 起止时间: 2009-03-01 至 2012-02-29
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7789621
• 关键词: Area; Biological; Biomedical Research; Chemicals; Clinical Pharmacology; Communication; Contracts; Core Facility; Data; Databases; Development; Doctor of Pharmacy; Doctor of Philosophy; Ensure; Environment; Equipment; Family; Floor; Foundations; Funding Agency; Gifts; Grant; Head; Hormonal; Housing; Image; Individual; Internet; Kansas; Laboratories; Lead; Location; Male Contraceptive Agents; Medical center; Minnesota; National Institute of Child Health and Human Development; Online Systems; Pharmaceutical Preparations; Principal Investigator; Procedures; Regulation; Research; Research Personnel; Research Project Grants; Research Support; Rest; Schedule; Science; Secure; Testing; Therapeutic; Travel; United States National Institutes of Health; Universities; cost; design; drug development; drug discovery; innovation; medical schools; meetings; reproductive; square foot; symposium

Summary of space allocated for the U54 Interdisciplinary Center for Male Contraceptive Research and Drug Discovery: New Biomedical Research Center (BRC) will house all U54 Research Project Principal Investigators and two support Core Units. The University of Kansas Medical Center will complete construction of a new $52 million research building containing 179,582 Net Assignable Square Feet (NASF). Occupancy of this building is schedule to begin in October, 2006 and be completed by December, 2006 and will include laboratory, office, and research support space for all of the U54 Research Project Principal Investigators as well as the Administrative and Imaging Cores of the U54 Center. These will all be located on the 33,294 square foot 3rd floor of the BRC (see Figure 1, next page). This floor will also be occupied by both the Interdisciplinary Center for Male Contraceptive Research and Drug Development and the Center for Reproductive Sciences, and thus represents a highly interactive, collaborative, and supportive environment for conducting the research on male contraceptive development. The individual labs in the BRC will be well equipped; there are no requests for equipment since the university has provided new equipment for all labs associated with this U54. Where appropriate, investigators have centralized equipment from their own labs into the core in order to reduce duplication and costs. However, most of the equipment in the cores (laboratories and administrative) was provided by the Dean's office of the School of Medicine and by matching of previous NIH grants. In addition, a $27 million gift from the Hall Family Foundation to the University of Kansas Medical Center provided for the purchase of new and replacement equipment for all of the investigators and cores moving into the BRC. The Drug, Discovery, Design & Synthesis Core (DDS Core) is housed in facilities at the University of Kansas-Lawrence and at the University of Minnesota. These are the same core facilities that are currently being utilized in our multi-campus NICHD contract "Synthesis and Testing of Non-hormonal Non-Steroidal Male Contraceptive Agents." The location of the facility at University of Kansas-Lawrence is about 30 miles from the University of Kansas Medical Center. During the current and previous contract on male contraceptive development, this distance provides no barrier to the smooth conduct of the research between the two campuses. Due to OSHA regulations, compounds submitted by the Drug, Discovery, Design & Synthesis core to investigators at University of Kansas Medical Center must be transported by commercial carriers (such as FEDEX overnight). This procedure will continue in the U54 center, as well as between the facilities at the University of Minnesota and the other campuses in the Center. Other administrative arrangements to ensure good communications between the core components and the rest of the center include: 1) A secure web-based data repository for chemical, physical, and biological data. 2) Drs. Tash, Georg, and Schonbrunn will be meet face-to-face at least every six months (additional travel costs will be covered by alternate funding sources) to make sure the core needs are being met smoothly. 3) Finally, all seminars and meetings involving center investigators will be available by web video conference at both campuses. The Drug Development Core (DD Core) is located in administrative space in facilities at both the University of Kansas Medical Center and at the University of Kansas-Lawrence. This core is probably unique in an academic center. The core is headed by Scott Weir, Pharm.D, Ph.D.. Dr. Weir's specific areas of expertise are in clinical pharmacology and developing innovative approaches in lead optimization and early drug development. Dr. Weir has developed drug products across a wide range of therapeutic areas. The DD Core facility at KUMC is located across the street from the BRC, where the research project labs and Administrative and Imaging cores are located.

分配了为U54跨学科研究中心分配的空间摘要 和药物发现： 新的生物医学研究中心（BRC）将容纳所有U54研究项目主要研究人员 和两个支持核心单位。堪萨斯大学医学中心将完成新的 5200万美元的研究大楼，其中包含179,582净可分配平方英尺（NASF）。这座建筑的占用 是2006年10月开始的时间表，并于2006年12月完成，包括实验室，办公室， 研究支持所有U54研究项目主要研究人员以及行政的研究支持空间 和U54中心的成像核心。这些都将位于33,294平方英尺的3楼上 BRC（见图1，下一页）。该楼层也将被两个跨学科中心占据 男性避孕研究和药物开发以及生殖科学中心，因此 代表了一个高度互动，协作和支持性的环境，用于进行男性的研究 避孕发展。 BRC中的个别实验室将配备良好；没有请求 设备以来，该大学为与此U54相关的所有实验室提供了新设备。在适当的地方， 调查人员将自己的实验室的集中设备集中到核心，以减少重复 和成本。但是，核心中的大多数设备（实验室和行政）由 医学院院长办公室和以前的NIH补助金。此外，一笔2700万美元 霍尔家庭基金会到堪萨斯大学医学中心的礼物提供购买 所有调查人员和核心进入BRC的新型和替换设备。 药物，发现，设计与合成核心（DDS核心）位于大学的设施中 堪萨斯州法律和明尼苏达大学。这些是当前正在的核心设施 在我们的多校区NICHD合同中使用的“非激素非甾体类雄性的合成和测试 避孕代理商。 堪萨斯大学医学中心。在当前和以前关于男性避孕开发的合同中， 这个距离没有障碍，这两个校园之间的研究平稳行为。 由于OSHA法规，该药物提交的化合物，发现，设计和合成核心向研究者提交的化合物 堪萨斯大学医学中心必须由商业承运人（例如FedEx过夜）运输。 该程序将继续在U54中心以及明尼苏达大学的设施之间继续 和中心的其他校园。其他行政安排以确保良好的沟通 在核心组件和中心的其余部分之间包括：1）一个安全的基于Web的数据存储库 用于化学，物理和生物学数据。 2）Drs。 Tash，Georg和Schonbrunn将在面对面见面 至少每六个月（额外的旅行费用将由替代资金来源支付），以确保 满足核心需求。 3）最后，所有涉及中心调查人员的研讨会和会议将是 在两个校园的网络视频会议上可用。 药物开发核心（DD Core）位于大学的设施中 堪萨斯医学中心和堪萨斯大学法律律师。这个核心可能是独一无二的 学术中心。核心由Scott Weir，Pharm.D，博士领导。Weir博士的特定专业领域是 在临床药理学和开发铅优化和早期药物开发方面的创新方法中。 Weir博士在广泛的治疗区域开发了药品。 DD核心设施位于 KUMC位于BRC的街对面，研究项目实验室以及行政和成像 芯位于核心。