Sleep, Circadian, Hormonal Dysregulation, and Breast Cancer Survival

睡眠、昼夜节律、荷尔蒙失调和乳腺癌生存

• 批准号: 7898730
• 负责人: David Spiegel
• 金额: $ 42.46万
• 依托单位: STANFORD UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2006
• 资助国家: 美国
• 起止时间: 2006-09-27 至 2012-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7898730
• 关键词: Affect; Age; Anxiety; Blood specimen; Cancer Patient; Circadian Rhythms; Clinical Research; Corticotropin; Electroencephalography; Emotional; Endocrine; Fatigue; Genes; Health; Home environment; Hormonal; Hormones; Hour; Hydrocortisone; Immune; Implant; Incidence; Laboratories; Malignant Neoplasms; Measures; Mediating; Melatonin; Mental Depression; Modeling; Monitor; Mus; NF-kappa B; Natural Killer Cells; Neurosecretory Systems; Outcome; Pain; Pattern; Phase; Polysomnography; Prognostic Factor; Recruitment Activity; Research; Risk; Sleep; Stress; Time; Tumor Necrosis Factor-alpha; Woman; cytokine; cytotoxicity; immune function; improved; malignant breast neoplasm; mortality; response; shift work; social; stressor; tumor growth; tumor progression

DESCRIPTION (provided by applicant): Recent research provides evidence that disrupted circadian rhythms, including hormonal patterns and sleep, are associated with increased risk of breast cancer incidence and faster progression to mortality. We have observed that loss of normal diurnal cortisol rhythm associated with more awakenings during the night predicts early mortality with metastatic breast cancer. Other recent studies have shown that nighttime shift work is associated with higher breast cancer incidence, and in a murine model disrupting circadian cortisol cycles produced a doubling of implanted tumor growth. There is also recent evidence that abnormal clock genes are associated with cancer. However, it is not clear whether sleep disruption per se affects breast cancer progression, or whether such an effect is mediated by hormonal and immune dysregulation of this prevalent and hormone-mediated cancer. We propose to study sleep disruption as a prognostic factor in the progression of metastatic breast cancer. We will also examine sleep patterns in association with disrupted circadian rhythms of cortisol, CRF, ACTH, and melatonin as well as measures of immune function known to be salient to breast cancer progression. These are natural killer cell cytotoxicity and specific cytokines: tumor necrosis factor alpha and nuclear factor kappa B. We plan to recruit 117 women 55 and older with metastatic breast cancer and 63 age and SES-matched controls for a two-week at home sleep study using Actiwatch and one night of in-home EEG monitoring, followed by 32 hours of EEG sleep monitoring and continuous blood sampling in the General Clinical Research Center. This will provide full circadian hormone assessment associated with thorough assessment of sleep patterns. We will relate these measures to the subsequent course of breast cancer progression. Results of this study will provide specific evidence regarding how improved sleep management may affect the course of breast cancer.

描述（由申请人提供）：最近的研究提供了证据表明，包括荷尔蒙模式和睡眠在内的昼夜节律中断，与乳腺癌发病率的风险增加和更快的死亡率相关。我们已经观察到，与更多觉醒相关的正常昼夜皮质醇节奏丧失在夜间预测转移性乳腺癌的早期死亡率。其他最近的研究表明，夜间轮班工作与较高的乳腺癌发生率有关，在鼠模型中，破坏昼夜节律皮质醇周期的鼠模型产生了植入肿瘤生长的两倍。最近还有证据表明异常时钟基因与癌症有关。但是，目前尚不清楚睡眠破坏本身是否会影响乳腺癌的进展，或者这种影响是否是由于这种流行和激素介导的癌症的激素和免疫失调而介导的。我们建议将睡眠破坏作为转移性乳腺癌进展的预后因素。我们还将检查与皮质醇，CRF，ACTH和褪黑激素的昼夜节律昼夜节律有关的睡眠模式，以及已知对乳腺癌进展显着的免疫功能的测量。 These are natural killer cell cytotoxicity and specific cytokines: tumor necrosis factor alpha and nuclear factor kappa B. We plan to recruit 117 women 55 and older with metastatic breast cancer and 63 age and SES-matched controls for a two-week at home sleep study using Actiwatch and one night of in-home EEG monitoring, followed by 32 hours of EEG sleep monitoring and continuous blood sampling in the General Clinical Research Center.这将提供与睡眠模式彻底评估相关的完整昼夜节律评估。我们将将这些措施与随后的乳腺癌进展过程联系起来。这项研究的结果将提供有关睡眠管理如何影响乳腺癌进程的具体证据。

项目成果

Use and misuse of the consolidated standards of reporting trials (CONSORT) guidelines to assess research findings: comment on Coyne, Stefanek, and Palmer (2007).

使用和滥用报告试验综合标准 (CONSORT) 指南来评估研究结果：对 Coyne、Stefanek 和 Palmer (2007) 的评论。

• DOI: 10.1037/0033-2909.135.2.173
• 发表时间: 2009
• 期刊: Psychological bulletin
• 影响因子: 22.4
• 作者: Kraemer,HelenaC;Kuchler,Thomas;Spiegel,David
• 通讯作者: Spiegel,David

Aberrant nocturnal cortisol and disease progression in women with breast cancer.

• DOI: 10.1007/s10549-016-3864-2
• 发表时间: 2016-07
• 期刊: Breast cancer research and treatment
• 影响因子: 3.8
• 作者: Zeitzer JM;Nouriani B;Rissling MB;Sledge GW;Kaplan KA;Aasly L;Palesh O;Jo B;Neri E;Dhabhar FS;Spiegel D
• 通讯作者: Spiegel D

Correspondence of plasma and salivary cortisol patterns in women with breast cancer.

• DOI: 10.1159/000367925
• 发表时间: 2014
• 期刊: Neuroendocrinology
• 影响因子: 4.1
• 作者: Zeitzer JM;Nouriani B;Neri E;Spiegel D
• 通讯作者: Spiegel D

Bedtime misalignment and progression of breast cancer.

• DOI: 10.3109/07420528.2013.842575
• 发表时间: 2014-03
• 期刊: Chronobiology international
• 影响因子: 2.8
• 作者: Hahm BJ;Jo B;Dhabhar FS;Palesh O;Aldridge-Gerry A;Bajestan SN;Neri E;Nouriani B;Spiegel D;Zeitzer JM
• 通讯作者: Zeitzer JM

Mind matters in cancer survival.

• DOI: 10.1002/pon.3067
• 发表时间: 2012-06
• 期刊: PSYCHO-ONCOLOGY
• 影响因子: 3.6
• 作者: Spiegel, David