CAM Approaches to Management of Sleep and Disease Progression in Cancer

CAM 管理睡眠和癌症疾病进展的方法

• 批准号: 7935421
• 负责人: David Spiegel
• 金额: $ 67.83万
• 依托单位: STANFORD UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2009
• 资助国家: 美国
• 起止时间: 2009-09-30 至 2012-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7935421
• 关键词: Acupuncture procedure; Behavior Therapy; Biology; Biomedical Engineering; Cancer Center; Cancer Patient; Circadian Rhythms; Clinical; Clinical Investigator; Complementary and alternative medicine; Consultations; Development; Disease Progression; Doctor of Philosophy; Effectiveness; Endocrine; Goals; Grant; Health; Hormonal; Hormones; Human; Hydrocortisone; Hypnosis; Immune system; Integrative Medicine; Interdisciplinary Study; Intervention; K-Series Research Career Programs; Link; Malignant Neoplasms; Medical; Mentors; Methods; Mission; Physicians; Physiology; Pilot Projects; Psychoneuroimmunology; Recruitment Activity; Research; Research Infrastructure; Research Personnel; Research Support; Scientist; Sleep; Sleeplessness; Solutions; Stress; Technology; Time; Universities; Work; body-mind; immune function; improved; knowledge base; malignant breast neoplasm; mindfulness; next generation; programs; public health relevance; ranpirnase; tumor progression

DESCRIPTION (provided by applicant): We propose to recruit a bright and productive young clinical investigator from the University of Rochester, Oxana Palesh, Ph.D., to a tenure-track Assistant Professorship and mentor her development as a researcher in CAM mind/body medical interventions. Her work will help us develop the Stanford P30 Mind-Body Core Center program linking our Stanford Center for Integrative Medicine, the Center on Stress and Health, and the Stanford Cancer Center. This Core Center program will study the effects of disruption in circadian rhythms (in particular sleep and dysregulation of Cortisol) on cancer progression and will evaluate the efficacy of CAM interventions in improving sleep and extending survival time with cancer. We have in place methods and facilities to study sleep and circadian hormonal rhythms and their interaction with immune function. This recruitment would put in place a full-time clinical researcher who has recently received a K Award from NCI to study sleep and breast cancer and evaluate the impact of behavioral interventions on sleep disruption, the capacity for self-soothing via improved vagal tone, and cancer survival. The P30 would allow us to complete Dr. Palesh's recruitment and develop a collaborative program involving the Stanford Cancer Center (Dr. Mitchell, Director) and researchers in psychoneuroimmunology (Dr.Dhabhar), sleep physiology (Dr. Zeitzer), breast cancer (Dr. Carlson), and Complementary and Alternative Medicine (CAM) treatments for sleep and insomnia researcher (Dr. Manber). It would also involve expert biostatistical consultation from Dr. Booil Jo, and would be directed by Dr. Spiegel, with expertise in psychooncology and integrative medicine. We plan to develop a strong mind/body integrative research focus linking circadian biology to cancer progression. The goals of this grant are: 1) to provide appropriate research support for Dr. Palesh to conduct her own research and to contribute to the overall scientific mission of the Mind/Body Core Center; 2) to utilize existing institutional strengths (e.g., infrastructure to study sleep, stress, endocrine and immune function, and disease progression) to develop and conduct pilot studies of the effects of CAM interventions (e.g., mindfulness, acupuncture, hypnosis) on sleep and cancer progression. PUBLIC HEALTH RELEVANCE: This Core Center would help us to recruit and support a promising young clinical researcher while building a program that examines the effectiveness of CAM interventions (mindfulness, acupuncture, hypnosis) in helping cancer patients to sleep better. Our core would also evaluate the effect of improved sleep on stress hormones, the immune system, and survival time with cancer.

描述（由申请人提供）：我们建议从罗切斯特大学招聘一位聪明、多产的年轻临床研究者 Oxana Palesh 博士担任终身教授助理教授，并指导她作为 CAM 思维/研究员的发展身体医疗干预。她的工作将帮助我们开发斯坦福 P30 身心核心中心计划，将斯坦福综合医学中心、压力与健康中心和斯坦福癌症中心联系起来。该核心中心项目将研究昼夜节律破坏（特别是睡眠和皮质醇失调）对癌症进展的影响，并将评估 CAM 干预措施在改善睡眠和延长癌症生存时间方面的功效。我们拥有适当的方法和设施来研究睡眠和昼夜荷尔蒙节律及其与免疫功能的相互作用。此次招聘将安排一名全职临床研究员，该研究员最近获得了 NCI 的 K 奖，负责研究睡眠和乳腺癌，并评估行为干预对睡眠中断的影响、通过改善迷走神经张力进行自我安抚的能力，以及癌症生存。 P30 将使我们能够完成 Palesh 博士的招募并开发一个合作计划，该计划涉及斯坦福癌症中心（主任 Mitchell 博士）和心理神经免疫学（Dhabhar 博士）、睡眠生理学（Zeitzer 博士）、乳腺癌（Dr. Zeitzer 博士）的研究人员卡尔森），以及睡眠和失眠研究人员的补充和替代医学（CAM）治疗（曼伯博士）。它还将涉及 Booil Jo 博士的生物统计专家咨询，并由具有心理肿瘤学和综合医学专业知识的 Spiegel 博士指导。我们计划开发一个强大的身心综合研究重点，将昼夜节律生物学与癌症进展联系起来。这笔赠款的目标是： 1) 为 Palesh 博士开展自己的研究提供适当的研究支持，并为心/身核心中心的整体科学使命做出贡献； 2) 利用现有的机构优势（例如研究睡眠、压力、内分泌和免疫功能以及疾病进展的基础设施）来开发和开展 CAM 干预措施（例如正念、针灸、催眠）对睡眠和睡眠的影响的试点研究癌症进展。 公共健康相关性：该核心中心将帮助我们招募和支持一位有前途的年轻临床研究人员，同时建立一个项目，检查 CAM 干预措施（正念、针灸、催眠）在帮助癌症患者改善睡眠方面的有效性。我们的核心还将评估改善睡眠对压力荷尔蒙、免疫系统和癌症生存时间的影响。