Resting State Functional MRI Investigation of Hypnotic Trance and Mindfulness Med

催眠恍惚和正念医学的静息态功能 MRI 研究

• 批准号: 7932315
• 负责人: David Spiegel
• 金额: $ 47.74万
• 依托单位: STANFORD UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2009
• 资助国家: 美国
• 起止时间: 2009-09-30 至 2012-09-29
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7932315
• 关键词: Address; Affect; Area; Attention; Autonomic nervous system; Base of the Brain; Brain; Brain region; Characteristics; Cognitive; Data; Functional Magnetic Resonance Imaging; Future; Goals; Hypnosis; Image; Investigation; Measurable; Medicine; Meditation; Methodology; Mind-Body Intervention; Nervous System Physiology; Pattern; Peripheral; Personal Satisfaction; Physiological; Positron-Emission Tomography; Research Personnel; Rest; Scanning; Technology; Treatment Efficacy; experience; hypnotic; mindfulness; mindfulness meditation; neuroimaging; novel; physical conditioning; public health relevance; relating to nervous system; trait

DESCRIPTION (provided by applicant): This application addresses broad Challenge Area (06) Enabling Technologies and specific Challenge Topic 06- AT-101*: Imaging correlates of brain states. Project Summary: Our goal is to determine the functional brain networks that define and distinguish two induced states of sustained attention -- hypnosis and mindfulness -- that may be of substantial relevance to medicine. Defining the neural underpinnings of these states would have broad implications for understanding how cognitive states emerge from functional networks, how they affect peripheral autonomic nervous system activity, and how their therapeutic efficacy can be optimized. This study seeks to address three specific aims: Aim 1: To determine representative neural signatures of the hypnotic and meditative states and associated trait characteristics in highly hypnotizable subjects and experienced meditators. Aim 2: To explore similarities and differences in the neural signatures of the hypnotic and meditative states. Aim 3: To determine the brain basis for autonomic nervous system changes induced by the hypnotic and meditative states. To address these aims, we will utilize novel applications of resting state fMRI and functional connectivity analysis - methodologies which are uniquely suited to overcome the limitations of prior PET or fMRI studies -- to compare 80 subjects evenly divided across four different groups: experienced meditators, novice meditators, highly hypnotizable subjects and minimally hypnotizable subjects. Each subject will undergo a single fMRI session during which they will be scanned under three continuous ten-minute conditions of 1) rest, 2) hypnotic trance or mindfulness meditation, and 3) an attention-demanding cognitive task. We will utilize functional connectivity analyses to characterize patterns of network activity in each state. This will allow for identification of network changes that characterize the several states under investigation. This approach should allow us to identify unique, objective neural signatures of hypnosis, meditation, and cognitive task-induced focused attention. In pursuing the third aim, physiologic data collected simultaneously with the fMRI data will be used to identify brain regions related to changes in autonomic nervous system function across the states. PUBLIC HEALTH RELEVANCE: Hypnotic trance and mindfulness meditation have both been shown to have benefits for physical health. The current study seeks to determine if there are distinct patterns of brain activity that correlate with hypnotic trance, mindfulness meditation or both, and to relate these patterns to measurable markers of physical well-being. Precise neuroimaging of heightened attentional states will guide future researchers and practitioners toward more effective techniques of mind/body control.

描述（由申请人提供）：本申请涉及广泛的挑战领域 (06) 支持技术和特定挑战主题 06-AT-101*：大脑状态的成像相关性。项目摘要：我们的目标是确定功能性大脑网络，这些网络定义和区分持续注意力的两种诱发状态——催眠和正念——这可能与医学有很大关系。定义这些状态的神经基础将对理解认知状态如何从功能网络中产生、它们如何影响外周自主神经系统活动以及如何优化它们的治疗效果具有广泛的意义。本研究旨在解决三个具体目标： 目标 1：确定高度易催眠的受试者和经验丰富的冥想者的催眠和冥想状态的代表性神经特征以及相关特征特征。目标 2：探索催眠状态和冥想状态神经特征的异同。目标 3：确定催眠和冥想状态引起的自主神经系统变化的大脑基础。为了实现这些目标，我们将利用静息态 fMRI 和功能连接分析的新颖应用（特别适合克服先前 PET 或 fMRI 研究局限性的方法）来比较 80 名受试者，这些受试者均匀地分为四个不同组：经验丰富的冥想者、冥想新手、高度易催眠的受试者和最低度易催眠的受试者。每个受试者将接受一次功能磁共振成像会议，在此期间他们将在三种连续十分钟的条件下进行扫描：1）休息，2）催眠恍惚或正念冥想，以及3）需要注意力的认知任务。我们将利用功能连接分析来表征每个状态的网络活动模式。这将允许识别所调查的几个州的网络变化特征。这种方法应该使我们能够识别催眠、冥想和认知任务引起的集中注意力的独特、客观的神经特征。为了实现第三个目标，与功能磁共振成像数据同时收集的生理数据将用于识别与各州自主神经系统功能变化相关的大脑区域。 公共健康相关性：催眠和正念冥想均已被证明对身体健康有益。目前的研究旨在确定是否存在与催眠恍惚、正念冥想或两者相关的独特大脑活动模式，并将这些模式与可测量的身体健康标记联系起来。对高度注意力状态的精确神经成像将指导未来的研究人员和从业者采用更有效的精神/身体控制技术。