CONSORTIUM: NORTHWESTERN UNIVERSITY

联盟：西北大学

• 批准号: 7695473
• 负责人: LUIS A. Nunes AMARAL
• 金额: $ 52.8万
• 依托单位: UNIVERSITY OF CHICAGO
• 依托单位国家: 美国
• 财政年份: 2008
• 资助国家: 美国
• 起止时间: 2008-09-01 至 2013-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7695473
• 关键词: Behavior; Biology; Chemistry; Chicago; Communities; Complement; Development; Developmental Biology; Education; Evolution; Faculty; Genomics; Goals; Institutes; Institution; Investigation; Lead; Leadership; Maps; Modeling; Performance; Physics; Physiological; Physiology; Pliability; Research; Research Infrastructure; Role; Stress; Structure-Activity Relationship; Systems Biology; Time; Universities; cluster computing; network models; new technology; outreach; pressure; programs

We propose to develop a Center for Systems Biology to promote interdisciplinary scientific investigation and education in Chicago. Faculty in the Institute for Genomics and Systems Biology at the University of Chicago will take a leadership role and together with collaborators at other Chicago institutions will create a broad outreach to the community. The Centers scientific program will focus on the robustness of transcriptional networks in physiological, developmental and evolutionary time scales. We propose to go beyond mapping Network topologies to develop dynamical models of the behavior of transcriptional regulatory networks during physiological stress, during cellular and organismal development, and during the evolution of species. These goals will be achieved by bringing together experts in genomics, developmental biology, evolutionary biology, stress and physiology, network modeling, high performance and grid computing, chemistry, and physics. The overarching aim of the Centers research is to uncover the organizational principles that transcriptional regulatory networks share as they respond to physiological, development and evolutionary inputs and pressures. These principles are expected to reveal structure-function relationships in networks that lead to physiological and evolutionary robustness or, its complement, flexibility.

我们建议建立一个系统生物学中心，以促进芝加哥的跨学科科学研究和教育。芝加哥大学基因组学和系统生物学研究所的教师将发挥领导作用，并与芝加哥其他机构的合作者一起向社区进行广泛的宣传。该中心的科学计划将重点关注转录网络在生理、发育和进化时间尺度上的稳健性。我们建议超越绘制网络拓扑结构，开发生理应激期间、细胞和有机体发育期间以及物种进化期间转录调控网络行为的动态模型。这些目标将通过汇集基因组学、发育生物学、进化生物学、压力和生理学、网络建模、高性能和网格计算、化学和物理学方面的专家来实现。该中心研究的首要目标是揭示转录调控网络在响应生理、发育和进化输入和压力时所共享的组织原则。这些原理有望揭示网络中的结构-功能关系，从而带来生理和进化的稳健性，或其补充，灵活性。