CLINICAL CENTER FOR CAMP

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• 批准号: 2317007
• 负责人: N FRANKLIN ADKINSON
• 金额: $ 123.5万
• 依托单位: JOHNS HOPKINS UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 1991
• 资助国家: 美国
• 起止时间: 1991-09-30 至 1999-12-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/2317007
• 关键词: CLINICAL; CENTER; CAMP; CLINICAL; CENTER; CAMP

Primary Objective To determine, in a population of 5-9 year old children with asthma, if regular use of either of two classes of anti-inflammatory medications (inhaled corticosteroids or cromolyn sodium), compared to regular bronchodilator medication and to each other, results in greater lung function and less bronchial hyperresponsiveness over a five year period. Secondary Objectives To determine if either of the anti-inflammatory medications, compared to bronchodilator medication and to each other, results in less patient morbidity, measured by frequency of asthma symptoms, days of limited activity, and days lost from school. To determine if either of the anti-inflammatory medications compared to regular bronchodilator medication and to each other results in less use of health care resources such as emergency room visits or hospitalizations. To compare the long term safety and side effects of the two classes of anti-inflammatory medications, compared to bronchodilator medication and to each other. To compare the effects of the two classes of anti-inflammatory medications, compared to bronchodilator medication and to each other, on physical and psychosocial development, and quality of life.

主要目标 确定，在5-9岁的哮喘儿童中 定期使用两类抗炎药 （吸入的皮质类固醇或克罗米金钠），与常规 支气管扩张剂药物，彼此之间，导致更大的肺 在五年内的功能和较少的支气管高反应性。 次要目标 确定任何一种抗炎药是否与 支气管扩张剂药物，彼此之间，导致患者较少 发病率，通过哮喘症状的频率来衡量，有限的天数 活动和放学的日子。 确定任何一种抗炎药是否与 常规的支气管扩张剂药物和彼此的使用量较少 医疗保健资源（例如急诊室访问或 住院。 比较两类的长期安全和副作用 与支气管扩张药物相比，抗炎药 彼此。 比较两类抗炎的影响 与支气管扩张药物相比，药物彼此相比 身体和社会心理发展以及生活质量。