EFFECT OF SALICYLATE ON THE ALLERGIC PHENOTYPE

水杨酸盐对过敏表型的影响

• 批准号: 7375840
• 负责人: N FRANKLIN ADKINSON
• 金额: $ 2.58万
• 依托单位: JOHNS HOPKINS UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2005
• 资助国家: 美国
• 起止时间: 2005-12-01 至 2006-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7375840
• 关键词: EFFECT; SALICYLATE; ALLERGIC; PHENOTYPE

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. In vitro studies have shown that salicylates can effect transcription of cytokines and interkeukins such as down-regulation of IL-4 which is pivotal in the synthesis of IgE antibody and the development of the allergic phenotype. In humans, inhaled salicylates inhibit early and late asthmatic responses to allergen lung challenge. This is a preliminary study to explore the role of salicylate in the therapy of asthma and allergic disease. The hypothesis is that salicylate therapy will shift cytokine production and surface marker expression away from the allergic phenotype. The proposed work will lay the groundwork for future studies to understand the biologic and molecular basis of anti-allergic effect of salicylate treatment.

该子项目是利用 NIH/NCRR 资助的中心拨款提供的资源的众多研究子项目之一。子项目和研究者 (PI) 可能已从另一个 NIH 来源获得主要资金，因此可以在其他 CRISP 条目中出现。列出的机构是中心的机构，不一定是研究者的机构。体外研究表明，水杨酸盐可以影响细胞因子和白细胞介素的转录，例如下调 IL-4，而 IL-4 在 IgE 抗体的合成和过敏表型的发展中至关重要。在人类中，吸入水杨酸盐可抑制对过敏原肺部攻击的早期和晚期哮喘反应。这是一项初步研究，旨在探讨水杨酸盐在治疗哮喘和过敏性疾病中的作用。假设水杨酸盐治疗将使细胞因子的产生和表面标志物的表达远离过敏表型。拟议的工作将为未来的研究奠定基础，以了解水杨酸盐治疗的抗过敏作用的生物学和分子基础。