IRREVERSIBLE AIRWAY DISEASE IN ASTHMA: EXHALED BREATH

哮喘中的不可逆气道疾病：呼气

• 批准号: 7375832
• 负责人: N FRANKLIN ADKINSON
• 金额: $ 1.76万
• 依托单位: JOHNS HOPKINS UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2005
• 资助国家: 美国
• 起止时间: 2005-12-01 至 2006-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7375832
• 关键词: IRREVERSIBLE; AIRWAY; DISEASE; ASTHMA; EXHALED

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The overarching goal of this research is to understand the pathophysiology and natural history of childhood asthma. A small portion of childhood asthmatics develop evidence of lung function impairment that is resistant to pharmacotherapy that may be due to irreversible airway disease. The central hypothesis is that young adults with irreversible airway disease may be differentiated from control asthmatics by structural and pathophysiological changes demonstrated by CT and increased methacholine airway sensitivity but not on the basis of induced sputum or EBC. This descriptive, pilot study seeks to employ two novel, non-invasive techniques exhaled breath condensates (EBC) and induced sputum (IS) to study airway remodeling and inflammation in asthma. Samples collected from 40 asthmatic adults and 40 age-matched controls will provide EBS and IC samples. The samples will be analyzed for markers of airway inflammation and remodeling. In addition several methodologic issues will be analyzed including diurnal variation, intra-subject reproducibility, between subject variance for asthmatic and normal subjects, optimal sampling time.

该子项目是利用NIH/NCRR资助的中心赠款提供的资源的许多研究子项目之一。子弹和调查员（PI）可能已经从其他NIH来源获得了主要资金，因此可以在其他清晰的条目中代表。列出的机构适用于该中心，这不一定是调查员的机构。这项研究的总体目标是了解儿童哮喘的病理生理学和自然史。儿童期哮喘患者的一小部分会产生肺功能障碍的证据，这种疾病对药物疗法具有抵抗力，这可能是由于不可逆转的气道疾病所致。 中心假设是，患有不可逆转气道疾病的年轻人可以通过CT和甲基苯胺气道敏感性提高的结构和病理生理变化与对照哮喘患者进行区分，但并非基于诱导的痰液或EBC。 这项描述性的，试点研究试图采用两种新型的非侵入性技术呼出的呼吸冷凝物（EBC）和诱导的痰液（IS）来研究哮喘中的气道重塑和炎症。从40名哮喘成年人和40个年龄匹配的对照组中收集的样品将提供EBS和IC样本。将分析样品的气道炎症和重塑标记。另外，将分析几个方法论问题，包括昼夜变化，受试者内的可重复性，哮喘和正常受试者的受试者方差之间，最佳抽样时间。