Looking Back to Look Forward: Social Environment Across the Life Course, Epigenetics, and Birth Outcomes in Black Families

回顾过去并展望未来：生命历程中的社会环境、表观遗传学和黑人家庭的出生结果

• 批准号: 10676220
• 负责人: Jaime Catherine Slaughter-Acey
• 金额: $ 59.91万
• 依托单位: UNIVERSITY OF MINNESOTA
• 依托单位国家: 美国
• 财政年份: 2021
• 资助国家: 美国
• 起止时间: 2021-09-30 至 2026-05-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10676220
• 关键词: Address; Affect; Aging; American; Archives; Back; Behavioral; Biological Aging; Biological Assay; Biological Markers; Birth; Birth Weight; Black Populations; Black race; Blood; Child; Cross-Sectional Studies; DNA Methylation; Data; Enrollment; Environment; Environmental Risk Factor; Epigenetic Process; Family; Fetal Growth; Generations; Genomics; Health; Healthcare; Individual; Length; Life Cycle Stages; Link; Measures; Mediating; Methylation; Modeling; Mothers; Neighborhoods; Newborn Infant; Outcome; Pathway interactions; Perinatal; Population; Pregnancy; Pregnant Women; Premature Birth; Race; Research; Research Personnel; Risk; Role; Sampling; Site; Social Environment; Socioeconomic Status; Source; Spottings; Stress; Stress and Coping; Theoretical model; Time; United States; Validation; Variant; Woman; Work; black women; black/white disparity; cohort; critical period; epigenome; epigenomics; health determinants; improved; indexing; infant outcome; insight; maternal stress; minority health; novel strategies; offspring; perinatal health; perinatal outcomes; prenatal; racial disparity; racism; social; social factors; sound; stressor; success; telomere

Improving the health outcomes for infants and children has been a national priority in the United States (US) for over a century. Despite great strides in improving perinatal health care and utilization among American women, key perinatal indicators have remained stagnant or worsened, the US continues to rank near the bottom, and racial disparities are persistent. While studies now have gone beyond behavioral and biomedical determinants of health and encompass the social environment, most research still remains focused on the time shortly before or during the pregnancy Improvements in perinatal health will require utilization of frameworks which integrate life-course and multiple-determinant models of health. Though the body of evidence linking the prenatal social environment, particularly maternal stress, and epigenome is growing, little work has yet explored the life course antecedents to the prenatal social environment and the impact on epigenetic methylation or telomere length. Based on our widely embraced framework for perinatal health that marries a multiple determinants model with a life course approach, we will investigate maternal social environmental influences on maternal methylation and telomere length. Change as well as critical periods will be assessed as the maternal social environment over the maternal life course may independently, cumulatively, and interactively impact the maternal epigenomic profile and its changes over the life course. Archived newborn blood spots, available for all pregnant women in this unique cohort of Black births in metro Detroit, will be assayed to determine the presence of epigenetic methylation and telomere length of mothers at their own birth; maternal measures at the index pregnancy will be derived from analogous blood spots collected in our study. Neighborhood level data will utilize both administrative and subjective measures of neighborhood. In addition to determining associations between the maternal social environment and her epigenomic features across her life course, we will endeavor to explore potential pathways linking the social environment and epigenome across the maternal life course with the perinatal outcomes of her offspring. Researchers have recently begun to consider social environmental factors and how they relate to epigenomic features as well as adverse perinatal outcomes. Yet those populations disproportionately affected by these outcomes are grossly underrepresented in genomic studies. Our sample of 1,000 births to Black women, with nearly half expected to women residing in Detroit, will provide a rich source of data on the maternal social environment across the life course and the epigenome. Our team possesses tremendous expertise in the study of perinatal outcomes as well as measures of social environmental factors often overlooked or not modeled in such a way as to provide understanding of mechanisms. Our study will substantially increase evidence about the importance of the maternal social context at multiple points in the life course on her epigenome and birth outcomes in offspring. The work holds promise for significantly increasing understanding about how social factors have influence across generations through epigenetic processes.

改善婴儿和儿童的健康状况一直是美国的国家优先事项 （美国）一个多世纪了。尽管美国人在改善围产期保健和利用方面取得了巨大进步 女性，关键围产期指标仍然停滞或恶化，美国继续排名垫底， 种族差异持续存在。虽然现在的研究已经超出了行为和生物医学的范围 健康的决定因素并涵盖社会环境，大多数研究仍然集中在时间上 怀孕前或怀孕期间改善围产期健康需要利用框架 它整合了生命历程和健康的多重决定因素模型。 尽管有大量证据表明产前社会环境，特别是产妇压力， 表观基因组正在增长，但探索产前社会环境的生命历程前因的工作还很少 以及对表观遗传甲基化或端粒长度的影响。基于我们广泛接受的框架 将多重决定因素模型与生命全程方法结合起来的围产期健康，我们将进行调查 母亲社会环境对母亲甲基化和端粒长度的影响。改变也是如此 将评估关键时期，因为孕产妇生命历程中的孕产妇社会环境可能会 独立、累积和交互地影响母体表观基因组谱及其随时间的变化 生命历程。存档的新生儿血斑可供这一独特的黑人出生群体中的所有孕妇使用 在底特律都会区，将进行分析以确定表观遗传甲基化和端粒长度的存在 母亲在自己出生时；怀孕指数的母亲测量值将源自类似的血点 收集在我们的研究中。邻里层面的数据将利用行政和主观措施 邻里。除了确定母亲的社会环境与她之间的关联之外 为了了解她整个生命过程中的表观基因组特征，我们将努力探索将社会与社会联系起来的潜在途径 整个母亲生命历程中的环境和表观基因组及其后代的围产期结局。 研究人员最近开始考虑社会环境因素及其与 表观基因组特征以及不良围产期结局。然而，这些人口受到的影响不成比例 这些结果在基因组研究中的代表性严重不足。我们的 1,000 名黑人出生样本 妇女，其中近一半预计是居住在底特律的妇女，将提供有关孕产妇的丰富数据来源 整个生命历程和表观基因组的社会环境。我们的团队在以下方面拥有丰富的专业知识 对围产期结局的研究以及经常被忽视或未建模的社会环境因素的测量 以提供对机制的理解的方式。我们的研究将大大增加关于 母亲生命历程中多个阶段的社会背景对其表观基因组和出生的重要性 后代的结果。这项工作有望显着增进对社会因素如何影响的理解 通过表观遗传过程对几代人产生影响。