Fish oil and neurovascular control in humans

鱼油和人类神经血管控制

• 批准号: 7851992
• 负责人: Jason R Carter
• 金额: $ 2.09万
• 依托单位: MICHIGAN TECHNOLOGICAL UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2008
• 资助国家: 美国
• 起止时间: 2008-02-01 至 2011-01-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7851992
• 关键词: Address; American; American Heart Association; Arterial Fatty Streak; Arts; Atherosclerosis; Blood Pressure; Blood Vessels; Blood flow; Cardiac; Cardiovascular Diseases; Cardiovascular system; Catecholamines; Coronary Arteriosclerosis; Data; Development; Diastolic blood pressure; Fish Oils; Forearm; Functional disorder; Future; Growth; Human; Hypertension; Hypotension; Incidence; Individual; Knowledge; Laboratories; Leg; Life; Limb structure; Link; Measures; Mediating; Methods; Muscle; Myocardial Ischemia; Nerve; Norepinephrine; Omega-3 Fatty Acids; Patients; Pilot Projects; Plethysmography; Population; Psyche structure; Recovery; Reporting; Research; Rest; Sex Characteristics; Stress; Supplementation; Techniques; Time; Triglycerides; United States; Vasodilation; Venous; Woman; biological adaptation to stress; experience; improved; men; normotensive; peroneal nerve; prevent; psychologic; relating to nervous system; research study; response; trafficking

DESCRIPTION (provided by applicant): The broad objective of this proposal is to examine the influence of fish oil (omega-3 fatty acids) on neurovascular control in humans. Specifically, this project will examine the effect of fish oil on: 1) resting blood pressure and muscle sympathetic nerve activity (MSNA) in normotensive and hypertensive individuals, and 2) neurovascular responses to mental stress in normotensive and hypertensive individuals. The specific aims of this project are: 1. To determine the effect of fish oil on blood pressure and MSNA at rest in humans. Resting blood pressure and MSNA will be measured before and after an eight-week fish oil supplementation period. Both normotensive and hypertensive subjects will be studied. It is hypothesized that fish oil will reduce blood pressure in hypertensive subjects, and that reductions in blood pressure will be associated with reductions in resting MSNA. 2. To determine the effect of fish oil on blood pressure and MSNA responses to mental stress. MSNA responses to mental stress will be measured directly from the peroneal nerve before and after an eight-week fish oil supplementation period. Both normotensive and hypertensive subjects will be studied. It is hypothesized that fish oil will inhibit blood pressure and MSNA responses to mental stress in hypertensive subjects. 3. To determine the effect of fish oil on forearm and calf vascular responses to mental stress. Forearm and calf blood flow responses to mental stress will be simultaneously recorded using venous occlusion plethysmography before and after an eight-week fish oil supplementation period. Both normotensive and hypertensive subjects will be studied. It is hypothesized that fish oil will enhance the forearm vasodilation response to mental stress, and that this response will be more dramatic in hypertensive subjects. 4. To determine the effect of fish oil on sympathetic and vascular recovery responses to mental stress. Post mental-stress blood pressure, MSNA and blood flow will be measured before and after an eight-week fish oil supplementation period. Both normotensive and hypertensive subjects will be studied. It is hypothesized that fish oil will reduce the amount of time required to return blood pressure, MSNA, and blood flow to baseline conditions after mental stress. Fish oil reduces the incidence of cardiovascular disease, but the mechanisms underlying this relationship remain unclear. This project will provide new knowledge regarding the effect of fish oil on neurovascular control in both normotensive and hypertensive humans.

描述（由申请人提供）：该提案的广泛目标是检查鱼油（欧米茄3脂肪酸）对人类神经血管控制的影响。具体而言，该项目将检查鱼油对以下方面的影响：1）血压和肌肉交感神经活动（MSNA）在正常和高血压个体中，以及2）正常性和高血压个体中对精神压力的神经血管反应。该项目的具体目的是：1。确定鱼油对人类血压和静止MSNA的影响。在八周的鱼油补充期之前和之后，将测量静息血压和MSNA。将研究出色的和高血压的受试者。假设鱼油将降低高血压受试者的血压，并且血压降低将与静息MSNA的减少有关。 2。确定鱼油对血压和MSNA对精神压力的反应的影响。 MSNA对精神压力的反应将直接从八周的鱼油补充期之前和之后直接从孔隙神经中进行测量。将研究出色的和高血压的受试者。假设鱼油会抑制高血压受试者的血压和MSNA对精神压力的反应。 3。确定鱼油对前臂和小腿血管对精神压力的影响。前臂和小腿血流对精神压力的反应将在八周的鱼油补充期之前和之后同时使用静脉闭塞散布。将研究出色的和高血压的受试者。假设鱼油将增强对心理压力的前臂血管舒张反应，并且这种反应在高血压受试者中会更加戏剧化。 4。确定鱼油对交感神经和血管恢复对精神压力的影响。在八周的鱼油补充期之前和之后，将测量精神压力后的血压，MSNA和血液。将研究出色的和高血压的受试者。假设鱼油将减少恢复血压，MSNA和血液流动所需的时间，并在精神压力后恢复基线条件。鱼油降低了心血管疾病的发生率，但这种关系的基础机制仍不清楚。该项目将提供有关鱼油对正常性和高血压人类神经血管控制的影响的新知识。

项目成果

Neurovascular responses to mental stress in prehypertensive humans.

高血压前期人群对精神压力的神经血管反应。

• DOI: 10.1152/japplphysiol.00912.2010
• 发表时间: 2011
• 期刊: Journal of applied physiology (Bethesda, Md. : 1985)
• 作者: Schwartz,ChristopherE;Durocher,JohnJ;Carter,JasonR
• 通讯作者: Carter,JasonR

Vestibulosympathetic reflex during the early follicular and midluteal phases of the menstrual cycle.

月经周期早期卵泡和黄体中期的前庭交感神经反射。

• DOI: 10.1152/ajpendo.00056.2008
• 发表时间: 2008
• 期刊: American journal of physiology. Endocrinology and metabolism
• 作者: Lawrence,JohnathanE;Ray,ChesterA;Carter,JasonR
• 通讯作者: Carter,JasonR

Menstrual cycle elicits divergent forearm vascular responses to vestibular activation in humans.

月经周期会引起人类前庭血管对前庭激活的不同反应。

• DOI: 10.1016/j.autneu.2009.11.002
• 发表时间: 2010
• 期刊: Autonomic neuroscience : basic & clinical
• 作者: Lawrence,JohnathanE;Klein,JennaC;Carter,JasonR
• 通讯作者: Carter,JasonR

Sympathetic neural responses to mental stress during acute simulated microgravity.

急性模拟微重力期间交感神经对精神压力的反应。

• DOI: 10.1152/japplphysiol.00284.2009
• 发表时间: 2009
• 期刊: Journal of applied physiology (Bethesda, Md. : 1985)
• 作者: Durocher,JohnJ;Schwartz,ChristopherE;Carter,JasonR
• 通讯作者: Carter,JasonR

Effects of oral contraceptives on sympathetic nerve activity during orthostatic stress in young, healthy women.

口服避孕药对年轻健康女性体位应激期间交感神经活动的影响。

• DOI: 10.1152/ajpregu.00554.2009
• 发表时间: 2010
• 期刊: American journal of physiology. Regulatory, integrative and comparative physiology
• 作者: Carter,JasonR;Klein,JennaC;Schwartz,ChristopherE
• 通讯作者: Schwartz,ChristopherE