Alcohol and Neurovascular Control in Humans

酒精与人类神经血管控制

• 批准号: 10237243
• 负责人: Jason R Carter
• 金额: $ 14.46万
• 依托单位: MONTANA STATE UNIVERSITY - BOZEMAN
• 依托单位国家: 美国
• 财政年份: 2017
• 资助国家: 美国
• 起止时间: 2017-09-15 至 2022-07-06
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10237243
• 关键词: Accidents; Accreditation; Acute; Address; Affective; Alcohol abuse; Alcohol consumption; Alcohols; Apnea; Arrhythmia; Attention; Autonomic Dysfunction; Baroreflex; Behavioral; Biological; Blood Pressure; Cardiovascular Diseases; Cardiovascular Physiology; Cardiovascular system; Collaborations; Consumption; Continuous Positive Airway Pressure; Coupled; Data; Dose; Drops; Exhibits; Female; Fingers; Goals; Gold; Heavy Drinking; Hour; Human; Hypertension; Incidence; Intervention; Laboratories; Life; Liquid substance; Measures; Mediating; Methods; Moods; Muscle; Myocardial Ischemia; Nerve; Obstructive Sleep Apnea; Ovarian Cycles; Phase; Plethysmography; Polysomnography; Prevalence; Psychomotor Performance; Randomized; Research; Respiration Disorders; Risk; Scientist; Sleep; Sleep Disorders; Sleep disturbances; Stroke; Techniques; Testing; Therapeutic; Time; United States National Institutes of Health; Woman; alcohol consequences; alcohol response; base; binge drinker; binge drinking; cardiovascular disorder risk; cardiovascular risk factor; control trial; drinking; epidemiology study; indexing; innovation; insight; male; men; negative affect; neuroregulation; neurovascular; novel; proliferative phase Menstrual cycle; relating to nervous system; response; sex; sex cycle; standard care; stressor; sudden cardiac death

Project Summary There is wide-spread recognition that `binge' alcohol consumption is associated with increased cardiovascular risk, but much of this is based on epidemiological studies and mechanisms remain poorly understood. Sympathetic overactivity has been suggested as a potential mechanism for alcohol-mediated cardiovascular disease, but direct evidence is lacking. The proposed project represents our first step in the pursuit of a long- term goal to explore alcohol-mediated hypertension, stroke, and sudden cardiac death, and practical interventions that might reduce the incidence of these cardiovascular conditions. The proposed project focuses on the impact of evening alcohol consumption on nocturnal and early morning autonomic function and reactivity in male and female binge drinkers. In aim 1, will determine the effect of evening alcohol consumption on nocturnal autonomic control and sympathetic neural responsiveness the subsequent morning. Aim 2 will determine the influence of sex (male vs. female) and the ovarian cycle (early follicular vs. midluteal phase) on sympathetic neural responsiveness to evening alcohol in humans. Aim 3 will determine if continuous positive airway pressure (CPAP) blunts alcohol-mediated sympathoexcitation at night and early morning. An exploratory aim will determine if autonomic responses to alcohol and CPAP are associated with affective states and psychomotor performance. Our central hypothesis is that evening alcohol consumption will elicit sympathetic overactivity at night and the subsequent morning, and that this sympathoexcitation will be augmented women and blunted after CPAP treatment. The novelty and innovation of this project is that our mechanistic aims are bolstered with an interventional aim that includes a randomized, control trial (CPAP vs. sham-CPAP). The project utilizes established, gold-standard methods for assessing sleep (polysomnography) and sympathetic neural activity and reactivity (microneurography). In summary, this project will determine the impact of simulated `binge' alcohol consumption on neural cardiovascular function at times of elevated cardiovascular risk (i.e., sleep and early morning) in male and female binge drinkers, and test a potential therapeutic strategy (i.e., CPAP) to blunt alcohol-induced autonomic dysfunction.

项目摘要 人们广泛认识到“暴饮暴食”饮酒与心血管增加有关 风险，但其中大部分是基于流行病学研究和机制的理解不足。 已提出交感神经过度活动作为酒精介导的心血管的潜在机制 疾病，但缺乏直接证据。拟议的项目代表了我们追求长期的第一步 探索酒精介导的高血压，中风和心脏猝死和实用性的术语目标 可能会减少这些心血管疾病的发生率的干预措施。拟议的项目重点 关于夜间饮酒对夜间和清晨自主神经功能的影响以及 男性和女性暴饮暴食者的反应性。在AIM 1中，将确定晚上饮酒的影响 随后的早晨，在夜间自主控制和交感神经反应上。 AIM 2意志 确定性别（男性与女性）和卵巢周期（卵泡早期与肠胃中期）的影响 人类对傍晚酒精的同情神经反应。 AIM 3将确定是否连续积极 气道压力（CPAP）在晚上和清晨钝化酒精介导的交感神经。一个 探索性目的将确定对酒精和CPAP的自主性反应是否与情感状态相关 和精神运动表现。我们的中心假设是晚上饮酒将引起 夜晚和随后的早晨的交感神经过度活动，这种同情心将是 CPAP治疗后增强妇女并钝化。这个项目的新颖性和创新是我们的 机械目的是通过包括随机的控制试验的介入目的来加强的（CPAP VS。 假-CPAP）。该项目利用已建立的金色标准方法评估睡眠（多摄影） 以及交感神经活动和反应性（微功能学）。总而言之，该项目将确定 模拟的“暴饮暴食”饮酒对升高时神经心血管功能的影响 男性和女性暴饮暴食者的心血管风险（即睡眠和清晨），并测试潜力 治疗策略（即CPAP），以钝酒精诱导的自主神经功能障碍。