A Population-Based Study of the Genomics and Long-Term Outcomes of AD/HD

AD/HD 的基因组学和长期结果的人群研究

基本信息

批准号：
7892560
负责人：
WILLIAM J. BARBARESI
金额：
$ 46.4万
依托单位：
MAYO CLINIC ROCHESTER
依托单位国家：
美国
项目类别：
财政年份：
2006
资助国家：
美国
起止时间：
2006-09-11 至 2013-07-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/7892560
关键词：
Achievement Address Adult Affect Alleles Attention deficit hyperactivity disorder Birth Blood specimen Child Childhood Clinic Clinical Complex Data Diagnostic Disease Etiology Frequencies Genes Genomics Goals Haplotypes Health Incidence Incidence Study Interdisciplinary Study Interview Knowledge Literature Longitudinal Studies Measures Minnesota NIH Program Announcements Outcome Personal Satisfaction Pharmaceutical Preparations Phenotype Pilot Projects Procedures Property Protocols documentation Psychometrics Publishing Questionnaires Reading Recording of previous events Research Resources Sampling Structure Symptoms System Testing Validity and Reliability Variant base birth control case control clinical phenotype cohort design disorder control health related quality of life improved instrument multidisciplinary neurobehavioral disorder neuropsychiatry population based psychosocial research facility response sound young adult

项目摘要

DESCRIPTION (provided by Applicant): This application describes a population-based study of the genomics and long-term outcomes of Attention- Deficit/Hyperactivity Disorder (AD/HD), in response to an NIH Program Announcement (PAS-03-092). Significant gaps exist in knowledge of long-term outcomes and the genomics of AD/HD, the most common, complex, neurobehavioral disorder in childhood. In our published study, all incidence cases of childhood AD/HD (n=379), and subjects with sub threshold childhood AD/HD (n=271), were identified in the 1976-1982, Rochester, Minnesota birth cohort (n=5,718). Subsequently, a pilot study has been completed, involving assessment of the current status of a sample of these subjects, now young adults with a history of childhood AD/HD, young adults with a history of sub-threshold childhood AD/HD, and matched controls from the birth cohort. The pilot study included a direct, standardized, structured, diagnostic neuropsychiatric interview, assessment of reading/math achievement, questionnaires to assess psychosocial outcomes, and blood samples for genomic studies. An adult AD/HD-specific health-related quality of life questionnaire (HRQOL) has also been piloted with these subjects. In the current application, these well developed research procedures will be applied to the entire cohort of young adult subjects with childhood AD/HD, sub threshold childhood AD/HD and matched controls from the 1976-1982 birth cohort to determine their clinical phenotype and to estimate the extent to which AD/HD persists into young adulthood. A nested, case-control design will be employed to compare the frequency of polymorphic alleles in potentially important components of the dopaminergic system; a primary focus will be the comparison between young adults with childhood AD/HD and non-AD/HD controls. During the subjects' assessments, long-term psychosocial and academic outcomes will be determined for AD/HD cases and controls and the association between medication treatment during childhood and psychosocial/academic outcomes in young adulthood will be determined. The psychometric properties of the adult AD/HD-specific HRQOL questionnaire will also be determined. Through this study, involving a multidisciplinary research team, a unique population-based birth cohort and exceptional research facilities, knowledge of the persistence of AD/HD into adulthood, genomics of the dopaminergic system in AD/HD, long-term psychosocial and academic outcomes associated with this disorder, and the association between medication treatment during childhood and outcomes in young adulthood will be substantially advanced.

描述（由申请人提供）：本申请描述了对NIH计划公告（PAS-03-092）的基因组学和注意力缺陷/多动障碍（AD/HD）（AD/HD）的长期结果的研究。长期结局的知识和AD/HD的基因组学的知识存在很大的差距，AD/HD是儿童期最常见，最复杂的神经行为疾病。在我们发表的研究中，在1976- 1982年，明尼苏达州罗切斯特（Rochester），明尼苏达州出生同胞（n = 5,718）中鉴定了所有儿童时期AD/HD（n = 379）的发病率（n = 379）和子阈值儿童ad/hd（n = 271）的受试者。随后，一项试点研究已经完成，涉及对这些受试者样本的当前状态的评估，现在有儿童广告/高清病史的年轻人，具有亚阈值儿童广告/高清病史的年轻人，以及来自出生队列的匹配控制。试点研究包括一项直接，标准化的，结构化的，诊断性的神经精神访谈，阅读/数学成就的评估，评估心理社会结果的问卷以及用于基因组研究的血液样本。成人AD/HD特异性健康相关的生活质量问卷（HRQOL）也已被这些主题驾驶。在当前的应用中，这些良好开发的研究程序将应用于具有儿童AD/HD的年轻成年受试者的整个队列，子阈值，子阈值AD/HD，并匹配1976- 1982年1982年的对照组，以确定其临床表型并估算AD/HD持续到年轻的成年的程度。将采用嵌套的病例对照设计来比较多巴胺能系统潜在重要组成部分中多态等位基因的频率；主要的重点将是具有儿童广告/HD和非AD/HD控制的年轻人的比较。在受试者的评估期间，将确定针对AD/HD病例和对照组的长期心理社会和学术成果，并确定儿童期间的药物治疗与年轻成年期的心理社会/学术成果之间的关联。还将确定成人AD/HD特异性HRQOL问卷的心理测量特性。通过这项研究，涉及一个多学科研究团队，一个独特的基于人群的出生队列和卓越的研究设施，对AD/HD持续到成年期的持续存在的知识，AD/HD中多巴胺能系统的基因组学，长期的心理社会和学术意识与这种疾病相关的长期心理社会和学术疲劳以及在儿童中的相关治疗与年轻人相关的药物治疗是实现年轻人和年轻人在Adfore in in od Adfore in in od Adfore in in od add of at in in od add的。