Adolescent Psychopathology: Implications of Co-Morbidity

青少年精神病理学：共病的影响

基本信息

批准号：
7792200
负责人：
ELIZABETH MCCAULEY
金额：
$ 49.55万
依托单位：
UNIVERSITY OF WASHINGTON
依托单位国家：
美国
项目类别：
财政年份：
2008
资助国家：
美国
起止时间：
2008-04-01 至 2012-03-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/7792200
关键词：
Accounting Address Adolescence Adolescent Adolescent Development Adult Affect Agreement Alcohol or Other Drugs use Area Behavior Categories Child Childhood Classification Clinical Cognition Cognitive Communities Comorbidity Complex Conduct Disorder DSM-IV Data Collection Depressive disorder Deterioration Development Developmental Process Diagnosis Diagnostic Disease Distress Dysthymic Disorder Emotional Emotions Environment Environmental Risk Factor Etiology Exposure to Expressed Emotion Family Family Relationship Feeling Foundations Freedom Future Gender Goals Growth Health Professional Healthy People 2010 Home environment Impairment Impulsivity Individual Intervention Interview Knowledge Literature Longitudinal Studies Measurement Measures Mental Depression Mental Health Mental disorders Modeling Moods Outcome Paper Parents Participant Pathway interactions Pattern Performance Persons Prevalence Prevention strategy Problem behavior Productivity Psychiatric Diagnosis Psychopathology Puberty Public Health Recording of previous events Relative (related person)Reporter Reporting Research Research Project Grants Resolution Risk Risk Factors Sampling Schools Scientist Self Concept Seminal Series Severities Sex Characteristics Shapes Specificity Staging Stress Structure Subgroup Substance abuse problem Symptoms System Temperament Testing Time Well in self Work Writing Youth adjudicate adverse outcome alcohol exposure anti social base boys cohort conflict resolution coping depressive symptoms design deviant disease classification early adolescence early onset substance use effective therapy emotion regulation emotional distress experience functional outcomes girls improved interest member parental monitoring peer prenatal exposure prevent public health relevance social stressor theories

项目摘要

DESCRIPTION (provided by applicant): According to the President's New Freedom Commission report, the ability to improve our understanding of childhood psychopathology has great public health significance. Mental health conditions cause one in ten children to suffer significant impairment at home, at school, and in the community. Critical to the Healthy People 2010 objective of reducing the prevalence of mental disorders among young people is a clearer understanding of the developmental processes underlying childhood psychopathology. In children, adolescents, and adults, comorbidity is the rule, rather than the exception. Yet to date most research on child and adolescent psychopathology has either disregarded the presence of or eliminated participants with co- morbid disorders. Neither approach is useful towards the end of addressing the needs of the majority of persons with mental health conditions who have co-occurring problems. The purpose of the proposed research is to explicate the development and resolution of co-occurring and non-co-occurring depressive and conduct problems by studying adolescents as they move into a period of marked escalation and gender differentiation in risk for major depressive, conduct, and substance abuse disorders. The proposed research project addresses key questions that have emerged regarding comorbidity by taking advantage of a unique opportunity to assess late adolescent psychopathology and related constructs in a community-based sample that has an overrepresentation of adolescents at risk for comorbid and non- comorbid depressive and conduct problems. The sample includes both girls and boys, is racially diverse, and was well-characterized, using a repeated measurement design with six assessments during the early adolescent years (6th-9th grades). In the proposed study 450 adolescents and a parent/guardian will undergo in- person interviews in the 12th grade. The research addresses the question of whether comorbidity is a developmental phenomenon of early adolescence. To this end both dimensional and categorical approaches will be used to determine the extent to which forms of psychopathology change from non-specific (mixed symptom presentation) to specific (presentation consistent with a specific form of adult psychopathology) over the course of adolescent development. Risk factors that contribute to escalating pathways towards specific and comorbid disorders and protective factors that mitigate early vulnerabilities to psychopathology will be identified. Functional outcomes in the areas of school, vocational, and social relationships of adolescents with comorbid and non-comorbid depressive and conduct problems will be compared to adolescents with neither form of psychopathology. Gender differentiation in developmental pathways will be explicated. The proposed research addresses a premier challenge facing mental health professionals by providing information that will highlight opportunities for intervention to reduce suffering and adverse consequences from comorbid psychiatric conditions that manifest during the adolescent developmental period.

描述（由申请人提供）：根据总统的新自由委员会报告，提高我们对童年心理病理学的理解的能力具有很大的公共健康意义。心理健康状况会导致十分之一的儿童在家里，学校和社区中遭受重大损害。对于健康人群而言，2010年降低年轻人精神障碍患病率的目标至关重要，这是对儿童精神病理学基础的发展过程的更清晰的理解。在儿童，青少年和成年人中，合并症是规则，而不是例外。然而，到目前为止，大多数关于儿童和青少年心理病理学的研究都忽略了患有病态疾病的参与者的存在或消除。这两种方法都在解决有同时发生问题的大多数患有精神健康状况的人的需求的结束时都有用。拟议的研究的目的是阐明同时发生和非疾病抑郁症的发展和解决，并通过研究青少年在重大抑郁，行为和药物滥用障碍的风险中显着升级和性别差异时，通过研究青少年来进行问题。拟议的研究项目通过利用独特的机会来评估青少年晚期的心理病理学和相关结构，在社区样本中评估了对合并症的关键问题，该样本中的青少年过度代表了对合并症和非合并症抑郁症的风险的过度占风险。样本包括男孩和男孩，在种族上是多样的，并且使用重复的测量设计，并在青少年初期（6-9年级）进行了六次评估。在拟议的研究中，有450名青少年和父母/监护人将在12年级接受访谈。该研究解决了合并症是否是青春期早期的发展现象的问题。为此，将使用维度和分类方法来确定心理病理学形式从非特异性（混合症状表现）变为特定（与特定形式的成人精神病理学一致）在青少年发展过程中的变化。将确定有助于提高特定和合并症的途径的危险因素以及减轻早期脆弱性心理病理脆弱性的保护因素。在学校，职业和社会关系领域的功能结果将与既不形式的心理病理学的青少年进行比较。将阐明发展发展途径的性别差异。拟议的研究通过提供信息来探讨心理健康专业人员面临的主要挑战，这些信息将强调干预的机会，以减少在青少年发育时期表现出的合并症精神病的痛苦和不利后果。