Selective Wirelessly-Adjustable Multiple-frequency Probe (SWAMP) Coil for MRI/S

用于 MRI/S 的选择性无线可调多频探头 (SWAMP) 线圈

• 批准号: 7788806
• 负责人: THOMAS H. MARECI
• 金额: $ 21.01万
• 依托单位: UNIVERSITY OF FLORIDA
• 依托单位国家: 美国
• 财政年份: 2009
• 资助国家: 美国
• 起止时间: 2009-05-01 至 2012-09-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7788806
• 关键词: Anatomy; Artificial Pancreas; Biochemical; Biomedical Engineering; Blood Glucose; Cell Nucleus; Clinical; Code; Computer Systems Development; Coupled; Coupling; Data; Development; Devices; Diabetes Mellitus; Disease; Failure; Frequencies; Gel; Glucose; Implant; Insulin; Life; Longitudinal Studies; Magnetic Resonance Imaging; Measurement; Measures; Metabolic; Metabolism; Methods; Modification; Monitor; Nuclear Magnetic Resonance; Organ; Pancreas; Patients; Performance; Physiologic pulse; Physiological; Physiology; Radio; Research Project Grants; Research Proposals; Signal Transduction; Spectrum Analysis; Spinal Cord; System; Technology; Testing; Time; Tissue Engineering; Tissues; Treatment Efficacy; Wireless Technology; biological systems; body system; design; digital; electric impedance; functional status; implantation; in vivo; innovation; instrument; interest; microchip; operation; programs; public health relevance; response; restoration; tool; voltage

DESCRIPTION (provided by applicant): In this project described in this revised proposal, a selective wirelessly-adjustable multiple-frequency probe (SWAMP) will be developed for non-invasive measurement of nuclear magnetic resonance (NMR) in vivo from a range of biologically important nuclei within implanted tissue constructs. This device will be instrumental in guiding the development of these tissue-engineered constructs by providing a method to monitor the viability and efficacy of these constructs in living subjects. But the same technology can be used to study a range of other significant biological systems, such as the spinal cord and other deep organ-systems, which require remote monitoring. Most importantly for our study, this device can non-invasively monitor the function of an implanted bioartificial-pancreas tissue construct. Therefore, the long-term objective of this project is to provide a clinical device that can be used in any magnet system to non-invasively examine the viability and function of a bioengineered tissue construct within a patient. The SWAMP system will use an NMR coil, implanted with the tissue construct, which is inductively coupled to an external coil. The development of this system will be accomplished by completing three specific aims: 1) Develop a microchip system to selectively tune an implanted NMR coil remotely to the frequency (nucleus) of interest and also develop an external-coil circuit, which will automatically impedance match the system. 2) Integrate these two components into the inductively coupled coil system and develop radio frequency pulse programs to automatically control the device. 3) Test the device performance by examining the functional status of a bioartificial pancreas tissue construct in gel phantoms during a longitudinal study of construct viability. This device is a major advance in NMR technology for monitoring implanted tissue or organs deep within the body. Current NMR implanted coil technology cannot be used to measure a full range of biologically important nuclei from implanted tissue without a severe loss of sensitivity for some nuclei. Therefore NMR measurements are not possible for this important range of nuclei without sacrificing significant biochemical information. The proposed SWAMP system overcomes this limitation through the innovative use of micro- fabrication technology to produce a single device that has optimum performance at all nuclei of interest and can be tuned remotely. Because of these significant performance improvements and ease of use, the SWAMP system can be used to obtain NMR data from a complete range of nuclei and provide critical information about the biochemical status of an implanted tissue construct. PUBLIC HEALTH RELEVANCE: Tissue constructs are a potential treatment of a range of diseases, such as diabetes using a bioartificial pancreas, which can replace the function of failed tissue, e.g. pancreas tissues. However artificial tissue constructs must be monitored to assure that they are functioning properly and to predict if they might fail, e.g. for diabetes, well in advance of changes in blood glucose levels. The proposed selective wirelessly-adjustable multiple-frequency probe for nuclear magnetic resonance can monitor an implanted tissue construct, such as a bioartificial pancreas, non-invasively by remotely selecting key nuclei to examine with optimum sensitivity.

描述（由申请人提供）：在此修订的提案中描述的项目中，将开发一个无线可调的多频率探针（SWAMP），用于从植入物组织结构中的一系列生物学重要核的核磁共振（NMR）对核磁共振（NMR）的非侵入性测量。该设备将通过提供一种方法来监测这些构建体在生命受试者中的可行性和功效的方法来指导这些组织工程结构的开发。但是，相同的技术可用于研究一系列其他重要的生物系统，例如脊髓和其他需要远程监测的深层器官系统。对于我们的研究，最重要的是，该设备可以非侵入性监测植入的生物人工胰腺组织构建体的功能。因此，该项目的长期目标是提供一种临床装置，可以在任何磁铁系统中使用，以非侵入性检查患者内生物工程组织构建体的生存能力和功能。沼泽系统将使用与组织构建体植入的NMR线圈，该构造与外部线圈耦合。该系统的开发将通过完成三个具体目的来完成：1）开发一个微芯片系统，以远程对植入的NMR线圈进行选择性调整感兴趣的频率（核）并发展外部线圈电路，该电路将自动阻止该系统。 2）将这两个组件集成到电感耦合的线圈系统中，并开发射频脉冲程序以自动控制设备。 3）通过检查构建生存能力的纵向研究期间，通过检查凝胶幻像中生物人工胰腺组织构建体的功能状态来测试设备性能。该设备是NMR技术的重大进步，用于监测体内深处的植入组织或器官。当前的NMR植入线圈技术不能用于测量植入组织中的全范围生物学上重要的核，而对于某些核的敏感性严重丧失。因此，对于这种重要的核范围，不可能在不牺牲重要的生化信息的情况下进行NMR测量。提出的沼泽系统通过创新的微制造技术来克服这种局限性，以生产一种具有最佳性能的单个设备，并且可以远程调整。由于这些显着的性能提高和易用性，沼泽系统可用于从完整的核范围获取NMR数据，并提供有关植入组织构建体的生化状态的关键信息。公共卫生相关性：组织结构是对多种疾病的潜在治疗方法，例如使用生物人工胰腺的糖尿病，可以取代失败的组织的功能，例如胰腺组织。但是，必须监视人造组织构建体以确保它们正常运行，并预测它们是否失败，例如对于糖尿病，在血糖水平的变化之前。提出的针对核磁共振的无线选择性多种频率探针可以通过远程选择关键核来监测植入的组织构建体，例如生物人工胰腺，以便以最佳的敏感性检查。