Environmental Determinants of Autoimmunity among African Americans in Coastal SC

南卡罗来纳州沿海非裔美国人自身免疫的环境决定因素

基本信息

批准号：
7934068
负责人：
DIANE L KAMEN
金额：
$ 46.35万
依托单位：
MEDICAL UNIVERSITY OF SOUTH CAROLINA
依托单位国家：
美国
项目类别：
财政年份：
2009
资助国家：
美国
起止时间：
2009-09-17 至 2013-06-30
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/7934068
关键词：
Acids Address Admixture Advisory Committees Affect African American Algorithms Antibodies Area Autoantibodies Autoimmune Diseases Autoimmune Process Autoimmunity Back Behavior Case-Control Studies Clinical Collaborations Communication Research Communities Community Outreach Community Participation Community Physician Consumption Data Data Collection Databases Development Dietary History Ecosystem Education Education and Outreach Enrollment Ensure Environment Environmental Exposure Environmental Hazards Environmental Health Environmental Pollution Environmental Risk Factor Epidemiologist Equipment and supply inventories Evaluation Exhibits Exposure to Family First Degree Relative Fishes Focus Groups Food Food Webs Frequencies Future Genetic Geographic Information Systems Goals Health Health Professional High Prevalence Human Immune System and Related Disorders Individual Interdisciplinary Study Interview Investigation Island Knowledge Link Lupus Measurement Modeling Monitor Nuclear Occupational Outcome Participant Pathway interactions Patients Play Population Population Study Process Public Health Questionnaires Recording of previous events Recruitment Activity Reinforcing Factor Relative (related person)Reporting Research Research Personnel Research Technics Resources Risk Role Sampling Scientist Sea Seafood Sentinel Serologic tests Serum Source South Carolina System Systemic Lupus Erythematosus Testing Time Toxic effect Tursiops Validation Variant Visit Work base case control community living consumer product design disorder prevention follow-up high risk improved informant information gathering interest meetings member multidisciplinary phenyl ether pollutant primary outcome programs public health relevance sound tool volunteer

项目摘要

DESCRIPTION (provided by applicant): The African American Gullah population of the Sea Islands of South Carolina and Georgia are a unique community for defining environmental factors for autoimmune diseases due to their low genetic admixture, environmental homogeneity, and a high prevalence of anti-nuclear antibody (ANA) positivity and families with multiple affecteds with systemic lupus erythematosus (SLE). With local seafood consumption being a dietary staple, potential pollutant contamination of the seafood is of high concern to the community. The basis for this concern is twofold. First, high levels of certain highly persistent organic pollutants (POPs), specifically polybrominated diphenyl ethers (PBDEs) and perfluoroalkyl acids (PFAAs), are found in local bottlenose dolphins and red drum, both sentinel wildlife species that serve as surrogates of human health effects. Second, links were recently established between these bioaccumulating, ubiquitous compounds and multiple deleterious health effects in humans, including immune system dysfunction and autoimmunity. As part of this proposal, we will study the immunological consequences associated with exposure to these specific environmental contaminants over time in first-degree relatives (FDRs) of patients with SLE, who are known to exhibit an increased risk of developing autoimmune disease themselves. The information gathered as part of this investigation will be used to support sound environmental public health action. The overall hypothesis of this proposal is that PBDEs and PFAAs play a pathogenic role as environmental triggers of autoimmunity in genetically at-risk individuals. We will test this hypothesis by accomplishing the following Specific Aims: 1) To test the hypothesis that residential, occupational and food frequency questionnaires are valid for assessing the burden of exposure to PBDEs and PFAAs among the African American Gullah community living in the Sea Island areas of South Carolina. 2) To test the hypothesis that serum levels of PBDEs and PFAAs will correlate with the presence of autoimmunity among first-degree relatives of patients with SLE and that levels of these bioaccumulating compounds increase over time within individuals exposed and that the rate of increase will correlate with the presence of autoimmunity. 3) To develop an algorithm to identify community members at high-risk for PBDE and PFAA exposure and test the hypothesis that cumulative exposure directly correlates with development and progression of autoimmunity. 4) To perform community outreach and education through a Steering Committee and public forums. 5) To evaluate the participatory process in reaching the educational and research objectives. PUBLIC HEALTH RELEVANCE: The proposed studies address concerns of the Sea Island African American community regarding bioaccumulating persistent organic pollutants found in local dietary staples such as fish. This study will provide important, not currently available information regarding the role of PBDEs and PFAAs as potential environmental triggers for the development and progression of autoimmune disease. The ultimate goal is to improve the quality of and community participation in multidisciplinary research on the human health effects of environmental exposures and develop effective strategies for exposure reduction and autoimmune disease prevention.

描述（由申请人提供）：南卡罗来纳州和佐治亚州海群岛的非裔美国人古拉人口是一个独特的社区，是一个独特的社区，可以定义自身免疫性疾病的环境因素，因为它们的遗传混合较低，环境均质性，以及抗核抗体（ANA）的较高的抗体抗体（ANA）和多重影响的抗体抗体（ANA）的较高流行。由于当地的海鲜消费是饮食中的主食，因此海鲜对海鲜的潜在污染物污染对社区引起了人们的关注。这种关注的基础是双重的。首先，在当地的瓶子糖浆和红色鼓中发现了高水平的某些高度持久的有机污染物（POP），特异性多溴二苯基醚（PBDES）和全氟烷基酸（PFAA），它们都是哨兵的瓶子糖，是哨兵野生动植物，它们都是人类健康影响的替代物的前哨野生动物。其次，最近在这些生物累积，无处不在的化合物和人类中多种有害健康效应（包括免疫系统功能障碍和自身免疫性）之间建立了联系。作为该提案的一部分，我们将研究与SLE患者的一级亲戚（FDR）随着时间的推移暴露于这些特定环境污染物的免疫学后果，这些患者众所周知，这些患者会出现增加自身免疫性疾病本身的风险。作为本调查的一部分收集的信息将用于支持合理的环境公共卫生行动。该提议的总体假设是，PBDE和PFAA是遗传风险个体自身免疫性的环境触发器的致病作用。我们将通过实现以下特定目的来检验这一假设：1）检验以下假设：住宅，职业和粮食频率问卷对于评估居住在南卡罗来纳州海岛地区的非裔美国人古拉社区中暴露于PBDES和PFAA的负担是否有效。 2）测试以下假设：PBDE和PFAA的血清水平与SLE患者的一级亲属之间的自身免疫性相关，并且这些生物累积化合物的水平随着暴露的个人而言随着时间的流逝而增加，并且增加的率将与自身免疫的存在相关。 3）开发一种算法来识别PBDE和PFAA暴露的高危社区成员，并测试累积暴露与自身免疫的发展和发展直接相关的假设。 4）通过指导委员会和公共论坛进行社区外展和教育。 5）评估达到教育和研究目标的参与过程。公共卫生相关性：拟议的研究涉及非裔美国人社区对在当地饮食主食（如鱼类）中发现的生物积累的持续有机污染物的关注。这项研究将提供有关PBDE和PFAA作为自身免疫性疾病发展和发展的潜在环境触发因素的重要信息。最终目标是提高有关环境暴露的人类健康影响的多学科研究的质量和社区参与，并制定有效的降低暴露策略和预防自身免疫性疾病。