Environmental Determinants of Lupus among African Americans

非裔美国人狼疮的环境决定因素

• 批准号: 9354400
• 负责人: DIANE L KAMEN
• 金额: $ 17.24万
• 依托单位: MEDICAL UNIVERSITY OF SOUTH CAROLINA
• 依托单位国家: 美国
• 财政年份: 2016
• 资助国家: 美国
• 起止时间: 2016-09-19 至 2021-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9354400
• 关键词: ARHGEF5 gene; Address; Affect; African American; Age; Americas; Autoantibodies; Autoimmune Diseases; Autoimmune Responses; Autoimmunity; Award; Biological Markers; Blood; Chronic; Clinical; Clinical Data; Clinical Investigator; Clinical Research; Communities; DNA; Data; Dedications; Development; Diagnosis; Diet; Disease; Educational Curriculum; Educational process of instructing; Ensure; Environment; Environmental Pollution; Environmental Risk Factor; Epitopes; Equilibrium; Etiology; Faculty; Feces; First Degree Relative; Food; Foundations; Frequencies; Funding; Future; Generations; Genes; Genetic; Genomics; Genotype; Goals; Grant; Health; Heavy Metals; Hour; Immune; Immune response; Incidence; Individual; Inflammatory; Intervention; Investigation; Island; K-Series Research Career Programs; Leadership; Longitudinal cohort; Lupus; Medical Students; Mentors; Metagenomics; Microbe; Modeling; Modification; National Institute of Arthritis and Musculoskeletal and Skin Diseases; National Institute of Environmental Health Sciences; Natural History; Operations Research; Participant; Pathogenesis; Pathway interactions; Patients; Pharmaceutical Preparations; Phenotype; Play; Population; Postdoctoral Fellow; Prevalence; Preventive; Prize; Production; Questionnaires; Recruitment Activity; Research; Research Personnel; Research Project Grants; Residencies; Rheumatology; Risk Factors; Role; Sampling; Sea; Severities; Smoking; Specificity; Structure; Students; Susceptibility Gene; Systemic Lupus Erythematosus; Talents; Taxonomy; Testing; Therapeutic; Time; Training; Trust; United States National Institutes of Health; Variant; Whole-Genome Shotgun Sequencing; Woman; Work; career; clinical development; cost; design; genetic variant; gut microbiome; gut microbiota; high throughput analysis; metagenome; microbial; microbial community; microbiome; next generation; patient oriented research; persistent organic pollutants; pre-clinical; public health relevance; risk variant; sex; trait; young woman

Project Description Dr. Kamen has devoted her career to conducting patient-oriented research in rheumatology with a focus on lupus and to mentoring the next generation of clinical investigators. Starting in residency, she has made continuous progress toward her goal of uncovering the natural history of autoimmune disorders in order to design preventive and therapeutic strategies around identified risk factors. While conducting highly interdisciplinary and collaborative research projects she has mentored 48 students, post-doctoral trainees and junior faculty. Dr. Kamen teaches medical students and residents as the co-Director of the Rheumatology Curriculum and oversees the clinical research operations as Director of Clinical Research for the Division of Rheumatology. Her dedication and track record for teaching and research mentoring were recognized in 2011 when she received the MUSC Developing Scholar Award and in 2012 when she received the Mary Betty Stevens Young Investigator Prize from the Lupus Foundation of America. This K24 Midcareer Investigator Award would ensure continued protected time for Dr. Kamen's research and mentoring. The proposed research project titled “Environmental Determinants of Lupus among African Americans” includes new aims which build upon ongoing work. This project explores the role of gut microbiota in the development of lupus-related autoimmunity. The proposed research has the strong support of the Sea Island Gullah African American community, with whom we have an established ongoing longitudinal cohort and a community-academic partnership. Participants for the proposed research project will be recruited from the existing ongoing longitudinal SLE in Gullah Health (SLEIGH) study to take advantage of genetic and clinical data already collected since the study's inception in 2003. Dr. Kamen's investigations have been continuously NIH funded, including a 5-year K23 Career Development Award from NIAMS that led to a 4-year R21 from NIEHS and a 5-year P60 project from NIAMS under Dr. Kamen's leadership. The vast amount of accumulated past exposure data, wealth of existing stored biospecimens, and enthusiasm from study participants to take part in a study of an autoimmune disease common in their community, present a unique opportunity to address the role of the gut microbiota in the development of autoimmunity.

项目描述 Kamen博士致力于进行以患者为导向的风湿病研究，重点是 狼疮，使下一代临床研究人员有心态。从居住开始，她做了 朝着她揭示自身免疫性疾病的自然历史的目标的持续进展 设计围绕已确定的风险因素的预防和治疗策略。同时进行高度进行 跨学科和协作研究项目她指导了48名学生，博士后学员和 初级教师。 Kamen博士教授医学生和居民为风湿病的共同导演 课程并监督临床研究操作为临床研究主任 风湿病。她在2011年获得了教学和研究指导的奉献记录 当她获得MUSC发展学者奖时，2012年她收到玛丽·贝蒂（Mary Betty） 美国狼疮基金会的史蒂文斯年轻调查员奖。这个K24中级研究员 奖项将确保Kamen博士的研究和指导继续受到保护的时间。 拟议的研究项目标题为“非洲裔美国人的狼疮的环境决定因素” 包括基于持续工作的新目标。该项目探讨了肠道菌群在 与狼疮相关的自身免疫的开发。拟议的研究得到了海岛的大力支持 古拉非裔美国人社区，我们与之建立了持续的纵向队列和一个 社区学术伙伴关系。拟议的研究项目的参与者将从 现有的Gullah Health（SLEIGH）研究中正在进行的纵向SLE研究以利用遗传和临床 自2003年研究开始以来已经收集的数据。卡门博士的调查一直是 NIH资助，包括Niams的5年K23职业发展奖，导致了4年R21 Niehs和Kamen博士领导下的Niams的5年P60项目。大量积累 过去的曝光数据，现有存储的生物测量的财富以及研究参与者的热情 一部分参与了社区中常见的自身免疫性疾病的研究，提供了一个独特的机会来解决 肠道菌群在自身免疫发展中的作用。