SYSTEMIC LUPUS ERYTHEMATOSUS IN GULLAH HEALTH (SLEIGH)

GULLAH HEALTH 中的系统性红斑狼疮（雪橇）

• 批准号: 7719572
• 负责人: DIANE L KAMEN
• 金额: $ 2.05万
• 依托单位: MEDICAL UNIVERSITY OF SOUTH CAROLINA
• 依托单位国家: 美国
• 财政年份: 2008
• 资助国家: 美国
• 起止时间: 2008-05-01 至 2009-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7719572
• 关键词: Affect; Africa; African American; Age; Area; Caucasians; Caucasoid Race; Cohort Studies; Computer Retrieval of Information on Scientific Projects Database; Development; Diagnostic tests; Disease; Environmental Exposure; Environmental Risk Factor; Family; Family member; Funding; Genes; Genetic; Grant; Health; Incidence; Institution; Island; Lead; Learning; Life; Lupus; Morbidity - disease rate; Oklahoma; Patients; Persons; Play; Population; Prevalence; Purpose; Rare Diseases; Research; Research Personnel; Resources; Sampling; Scientist; Sea; Socioeconomic Factors; Source; South Carolina; Systemic Lupus Erythematosus; USA Georgia; United States; United States National Institutes of Health; Western Asia Georgia; Work; body system; improved; mortality; socioeconomics

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The SLE in Gullah Health (SLEIGH) study is an observational cohort study of patients, their family members, and unrelated controls from the African American Gullah population living in the Sea Island areas of South Carolina and Georgia. The purpose of the SLEIGH study is to study both environmental and genetic contributions to SLE. The African American Gullah population is unique in its genetic homogeneity and stable family unit, making them a valuable cohort for the study of multigenic diseases such as SLE. Our central hypothesis in the SLEIGH study is that there are specific genetic factors that interact with environmental exposures leading to the development of SLE. African Americans have a three-fold increased incidence of SLE, develop SLE at an earlier age, and have increased SLE-related morbidity and mortality compared with Caucasians. It is likely that multiple factors, including genetic, environmental, and socioeconomic factors, underlie the ethnic disparity in SLE. Socioeconomic and genetic differences alone, however, cannot explain the significant increase in prevalence of SLE in the past 20 years or the gradient of SLE between West Africa where it is a rare disease, and the United States where it is prevalent. These latter findings suggest environmental factors are at play. The purpose of the study of Systemic Lupus Erythematosus (SLE) is to determine its cause, to improve understanding of it, and to help find new therapies. One very important part of this study is to help find the genes that cause lupus and to explain how they work. Learning what the genes are and how they work is expected to help lead toward advances that improve the diagnostic tests for lupus and the therapies for lupus. Lupus is a disease that may affect many different organ systems and how it affects people is often very different from person to person. Scientists will use samples and selected information from subjects to achieve this purpose. These scientists will be working both in Oklahoma and in other places.

该副本是利用众多研究子项目之一 由NIH/NCRR资助的中心赠款提供的资源。子弹和 调查员（PI）可能已经从其他NIH来源获得了主要资金， 因此可以在其他清晰的条目中代表。列出的机构是 对于中心，这不一定是调查员的机构。 Gullah Health的SLE（SLEIGH）研究是一项对患者，家庭成员以及居住在南卡罗来纳州和乔治亚州海岛地区的非裔美国人Gullah人口的无关控制的观察队列研究。 Sleigh研究的目的是研究对SLE的环境和遗传贡献。 非裔美国人的古拉人口在其遗传同质性和稳定的家庭单位方面是独一无二的，使其成为研究多基因疾病（例如SLE）的宝贵队列。我们在雪橇研究中的中心假设是，有一些特定的遗传因素与环境暴露相互作用，导致SLE的发展。 非洲裔美国人的SLE发病率增加了三倍，与高加索人相比，与SLE相关的发病率和死亡率提高了。 SLE中种族差异的基础可能是多种因素，包括遗传，环境和社会经济因素。但是，仅靠社会经济和遗传差异就无法解释过去20年中SLE患病率的显着增加，也不能解释西非是一种罕见疾病的SLE梯度，以及它普遍存在的美国。这些后一个发现表明环境因素正在发挥作用。 全身性红斑狼疮（SLE）研究的目的是确定其原因，改善对其的理解并帮助寻找新的疗法。 这项研究的一个非常重要的部分是帮助找到引起狼疮的基因并解释它们的工作原理。 学习基因是什么以及如何工作，有助于帮助改善狼疮的诊断测试和狼疮的疗法。 狼疮是一种可能影响许多不同器官系统及其影响人们的疾病，与人之间的影响通常非常不同。 科学家将使用来自受试者的样本和选定信息来实现此目的。 这些科学家将在俄克拉荷马州和其他地方工作。