Pediatric Template of Brain Perfusion

儿科脑灌注模板

• 批准号: 7815448
• 负责人: Danny JJ WANG
• 金额: $ 2.15万
• 依托单位: UNIVERSITY OF PENNSYLVANIA
• 依托单位国家: 美国
• 财政年份: 2009
• 资助国家: 美国
• 起止时间: 2009-09-30 至 2010-05-04
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7815448
• 关键词: Address; Adolescence; Adult; Age; Anisotropy; Arts; Atlases; Back; Base of the Brain; Behavior; Behavioral; Biological Neural Networks; Blood flow; Book Chapters; Brain; Brain Diseases; Brain region; Cerebrovascular Circulation; Cerebrum; Child; Childhood; Clinical; Cognitive; Communities; Computer software; Contrast Media; Cross-Sectional Studies; Data; Data Collection; Data Set; Databases; Dependence; Development; Diffusion; Diffusion Magnetic Resonance Imaging; Evaluation; Evolution; Functional Magnetic Resonance Imaging; Funding; Future; Hippocampus (Brain); Human; Image; Image Analysis; Journals; Knowledge; Light; Longitudinal Studies; Magnetic Resonance Imaging; Measurement; Measures; Memory; Mental disorders; Methodology; Methods; Modality; Multivariate Analysis; National Institute of Mental Health; Neuroanatomy; Neurodevelopmental Disorder; Parents; Parietal; Pattern; Pediatric Hospitals; Pediatric Research; Peer Review; Pennsylvania; Performance; Perfusion; Perfusion Weighted MRI; Philadelphia; Physiological; Population; Positioning Attribute; Prefrontal Cortex; Process; Productivity; Property; Protocols documentation; Public Health; Publications; Radioisotopes; Regional Perfusion; Relative (related person); Reproducibility; Research; Resources; Rest; Safety; Scanning; Sex Characteristics; Short-Term Memory; Signal Transduction; Spin Labels; Statistical sensitivity; Structure; System; Technical Expertise; Thick; Time; Universities; Update; Variant; Work; aged; angular gyrus; association cortex; base; bioimaging; blood flow measurement; blood oxygen level dependent; cognitive neuroscience; cohort; design; image registration; imaging modality; improved; indexing; morphometry; neurogenetics; neuroimaging; parent project; pre-clinical; public health relevance; relating to nervous system; response; white matter

DESCRIPTION (provided by applicant): We propose "An Integrated Pediatric Template of Brain Structure and Function" - a multivariate quantitative image assessment of the developing brain. The template will be openly available to all and will be used to enumerate the interaction between working memory performance and cortical and connectivity maturation. The parent project's over-arching aim is validate, construct and distribute a MRI-based statistical atlas (or template) that describes the developmental trajectory of blood flow patterns (or perfusion) in the "normal" pediatric brain and its responses to working memory tasks. Here, we add depth to the imaging dataset collected from this large cohort through additional, state-of-the-art scanning. We also add rigor and breadth of appeal to the associated analysis by introducing cutting-edge computational neuroanatomy and multivariate statistical processing to tease out cross-modality interactions, network-node relationships and effects of these on cognitive processing. In particular, we achieve this through advanced diffusion tensor imaging, cutting-edge cortical thickness and analyses and multivariate sparse regression of the parameters, along with perfusion, and working memory performance. PUBLIC HEALTH RELEVANCE: This proposal responds to public health needs through large-scale data collection that enables studies of cross-sectional sex differences in developmental trajectories and behavior. Secondly, the proposal supports longitudinal neuroimaging studies in mental disorders by performing a normative 4 time point multi-modality study of normal longitudinal development in 30 children.

描述（由申请人提供）：我们提出“大脑结构和功能的综合儿科模板”——对发育中的大脑进行多变量定量图像评估。 该模板将向所有人开放，并将用于枚举工作记忆性能与皮质和连接成熟之间的相互作用。 父项目的总体目标是验证、构建和分发基于 MRI 的统计图集（或模板），该图集描述“正常”儿科大脑中血流模式（或灌注）的发育轨迹及其对工作记忆任务的反应。 在这里，我们通过额外的、最先进的扫描来增加从这个大队列中收集的成像数据集的深度。 我们还通过引入尖端的计算神经解剖学和多元统计处理来梳理出跨模态交互、网络节点关系及其对认知处理的影响，从而增加了相关分析的严谨性和广度。 特别是，我们通过先进的扩散张量成像、尖端的皮质厚度和参数分析和多元稀疏回归以及灌注和工作记忆性能来实现这一目标。 公共卫生相关性：该提案通过大规模数据收集来满足公共卫生需求，从而能够研究发育轨迹和行为的横截面性别差异。 其次，该提案通过对 30 名儿童的正常纵向发育进行规范性 4 时间点多模态研究，支持精神障碍的纵向神经影像学研究。