Task Order One (1) shall encompass conduct of and support for core study operations, data analysis, manuscript preparation, and morbidity and mortality ascertainment. The Field Center shall contact su

任务令一 (1) 应包括开展和支持核心研究操作、数据分析、稿件准备以及发病率和死亡率确定。

• 批准号: 10683913
• 负责人: ADOLFO CORREA
• 金额: $ 171.85万
• 依托单位: UNIVERSITY OF MISSISSIPPI MED CTR
• 依托单位国家: 美国
• 财政年份: 2022
• 资助国家: 美国
• 起止时间: 2022-08-13 至 2023-08-12
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10683913
• 关键词: Abdomen; Address; African American; African American population; Age; Aorta; Area; Atherosclerosis Risk in Communities; Back; Behavioral Genetics; Biochemical; Biological; Biological Assay; Biomedical Research; Candidate Disease Gene; Cardiovascular Diseases; Cardiovascular system; Clinic; Clinical; Cohort Studies; Collaborations; Communities; Community Health Education; County; Cryopreservation; DNA; Data; Data Analyses; Data Collection; Data Set; Development; Disease; Echocardiography; Education and Outreach; Educational Status; Enrollment; Environmental Risk Factor; Event; Family; Family Sizes; Fostering; Genetic Risk; Genome Scan; Goals; Heart failure; Hospitalization; Impaired cognition; Injury; Investigation; Jackson Heart Study; Lymphocyte; Manuscripts; Mathematics; Measures; Morbidity - disease rate; Participant; Preparation; Psychosocial Factor; Publications; Research; Resources; Risk Factors; Sampling; Science; Scientist; Subgroup; Testing; Training Programs; Validation; Ventricular Dysfunction; Vital Status; X-Ray Computed Tomography; aged; biomedical profession; cardiac magnetic resonance imaging; cardiovascular disorder risk; cardiovascular health; career; cognitive function; cohort; college; community living; disorder risk; epidemiology study; follow-up; healthy lifestyle; heart imaging; high school; improved; interest; member; metropolitan; mortality; novel; operation; programs; recruit; residence; risk prediction; social culture; socioeconomics; undergraduate student; underrepresented minority student

The Jackson Heart Study (JHS), initiated in 1998, is a longitudinal investigation of genetic and environmental risk factors associated with the disproportionate burden of cardiovascular disease (CVD) in African-Americans. In addition, the JHS performs a variety of community education and outreach activities to promote healthy lifestyles and reduce disease risk burden. It also conducts college undergraduate and graduate-level training programs and high school science and math enrichment programs to prepare and encourage underrepresented minority students to pursue biomedical careers. (www.jacksonheartstudy.org/). The JHS represents an expansion of the Jackson Field Center of the Atherosclerosis Risk in Communities (ARIC) study (www2.cscc.unc.edu/aric/), to broaden data collection in an African- American population and to increase access to and participation of African American populations and scientists in biomedical research and professions. The study recruited 5306 African-American residents, including 3,732 residents also enrolled in ARIC, living in the Jackson, MS, metropolitan area of Hinds, Madison, and Rankin Counties. Enrolled JHS participants, initially aged 20 - 90 years, received three back-to-back examinations (Exam 1, 2000-04; Exam 2, 2005-08; and Exam 3, 2009-13) and have been contacted annually. Findings on the rich set of data on physical, behavioral, genetic, and psychosocial factors have been presented in over 345 publications as of the end of 2016. Participant exams have produced extensive longitudinal data on traditional and putative CVD risk factors, socioeconomic and sociocultural factors, and biochemical analytes; and measures of subclinical disease from echocardiography, cardiac magnetic resonance imaging (MRI), and computed tomography (CT) scans of the heart, aorta, and abdomen. Stored biological samples have been assayed for putative biochemical risk factors and stored for future research. DNA has been extracted and lymphocytes cryopreserved for study of candidate genes, genome-wide scanning, expression, and other –omics investigations. The study included a nested component of 428 families with mean family size of 5 at baseline; today 331 families with at least 1 living member still actively participate. Participation of the surviving cohort has been high: 80% (N=4205) and 72% (N=3820) at each of the two respective follow-up examinations. Today the average cohort age is 68 years. Since baseline, cohort members have also been contacted every 12 months to obtain information on vital status, current residence, major illness or injury, and hospitalizations occurring between contacts to identify incident clinical CVD events of interest. Due to JHS’ shared cohort membership with ARIC, the two studies cooperate with each other on events validation.

杰克逊心脏研究 (JHS) 于 1998 年启动，是一项针对非裔美国人心血管疾病 (CVD) 负担过高的遗传和环境风险因素的纵向调查。此外，JHS 还开展各种社区教育和研究。它还开展大学本科和研究生水平的培训计划以及高中科学和数学强化计划，以准备和鼓励少数族裔学生从事生物医学职业。 （www.jacksonheartstudy.org/）。 JHS 是杰克逊社区动脉粥样硬化风险研究中心 (ARIC) 的扩展 (www2.cscc.unc.edu/aric/)，旨在扩大非裔美国人群体的数据收集范围并增加获取和参与的机会该研究招募了 5306 名非裔美国居民，其中包括 3,732 名居住在密西西比州杰克逊市都会区的 ARIC 居民。 Hinds、Madison 和 Rankin 县的注册 JHS 参与者，最初年龄为 20 - 90 岁，接受了三项连续考试（考试 1，2000-04；考试 2，2005-08；考试 3，2009-13）。截至目前，有关身体、行为、遗传和心理社会因素的丰富数据集的研究结果已在超过 345 种出版物中发表。 2016年底。 参与者检查产生了关于传统和假定的 CVD 危险因素、社会文化和社会文化因素以及生化分析物的广泛纵向数据；以及通过超声心动图、心脏磁共振成像 (MRI) 和心脏计算机断层扫描 (CT) 测量亚临床疾病的数据。 、主动脉和腹部的生物样本已用于假定的生化危险因素分析，并已提取 DNA 并冷冻保存用于候选基因的研究。全基因组扫描、表达和其他组学研究包括 428 个家庭，基线时平均家庭规模为 5 人；目前有 331 个家庭，其中至少有 1 名幸存成员积极参与。两次随访检查的平均年龄分别为 80% (N=4205) 和 72% (N=3820)。还每 12 个月联系一次成员，以获取有关接触者之间发生的生命状况、当前居住地、重大疾病或受伤以及住院情况的信息，以确定感兴趣的临床 CVD 事件。由于 JHS 与 ARIC 共享队列成员资格，这两项研究。在事件验证方面相互合作。