C0RE--ANIMAL MODELS

C0RE--动物模型

• 批准号: 7564012
• 负责人: YVETTE FRANCE TACHE
• 金额: $ 16.44万
• 依托单位: UNIVERSITY OF CALIFORNIA LOS ANGELES
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/7564012
• 关键词: Animal Model; Animals; Blood flow; Blood specimen; Body Fluids; Brain; Data Analyses; Digestive System Disorders; Equipment; Experimental Models; Gene Mutation; Hormonal; Injury; Intestines; Maps; Measures; Methods; Motor; Mucous Membrane; Mus; Neural Pathways; Neurons; Neurotransmitters; Peptides; Pharmaceutical Preparations; Program Development; Protocols documentation; Rattus; Research; Research Personnel; Resistance; Rodent; Stomach; Tissue Banks; Transgenic Animals; Transgenic Organisms; Upper arm; design; gastrointestinal; gastrointestinal function; in vivo; member; neuroregulation

The overall objective of the Animal Models Core is to provide expertise to members of the CURE: Digestive Diseases Research Core Center (CURE: DDRCC) for in vivo characterization of normal and pathophysiological mechanisms of hormonal and neural regulation of gastrointestinal (GI) function and brain-gut interactions in rodents. The specific objectives are to provide CURE: DDRCC investigators access to: (1) in vivo experimental models to assess gastric and intestinal function in rats and mice; (2) specialized facilities and equipment to measure GI secretions, motor function, blood flow, resistance of the mucosa to injury and functional mapping of neuronal activity at the cellular level; (3) methods for in vivo administration of peptides, neurotransmitters, and drugs, sampling blood and body fluids, and tissue collection; (4) methods to assess afferent and efferent arms of the neural pathways involved in brain-gut interactions; (5) expertise in protocol design, data analysis and program development for analysis of electrophysiological traces; and (6) transgenic animals with specific gene mutations through interaction with transgenic Cores within UCLA.

动物模型核心的总体目标是为治疗成员提供专业知识： 消化系统疾病研究核心中心（治疗：DDRCC），用于在啮齿动物中胃肠道功能（GI）功能（GI）功能的正常和病理生理机制的体内表征。具体目标是提供治疗：DDRCC研究人员访问：（1）体内实验模型评估大鼠和小鼠的胃功能； （2）测量胃肠道分泌物，运动功能，血流，粘膜对损伤的耐药性和神经元活性在细胞水平上的功能映射的专业设施和设备； （3）用于体内给药肽，神经递质和药物的方法，取样血液和体液以及组织收集； （4）评估与脑ut的神经途径的传入和传出臂的方法 互动； （5）协议设计，数据分析和计划开发的专业知识，用于分析电生理痕迹； （6）具有特定基因突变的转基因动物通过与UCLA内的转基因核的相互作用。